Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tohru Sugawara"'
Publikováno v:
STAR Protocols
Summary We recently demonstrated that the zygotic gene Zscan5b is involved in maintaining the genomic integrity of pluripotent stem cells (PSCs) during mitosis and that Zscan5b gene expression can prevent chromosomal abnormalities. Here, we provide a
Autor:
Hidenori Akutsu, Kenji Miyado, Shoko Miyajima, Tohru Sugawara, Akari Nakamura, Yasunori Yoshimura, Jun Miyauchi, Toshio Hamatani, Seiji Ogawa, Mitsutoshi Yamada, Mamoru Tanaka, Akihiro Umezawa, Akihiro Nakamura, Hideki Tsumura, Yuichirou Harada, Ryuichiro Okawa, Reina Ooka
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1366-1379 (2019)
Summary: Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b,
Autor:
Justin K. Ichida, Jesse D. Lai, Gabriel R. Linares, Shu-Ting Hung, Tohru Sugawara, Shaoyu Lin, Gabriel Rocha, Yingxiao Shi, Kim A. Staats, Carina Seah, Michael Chickering, Yaoming Wang, Berislav V. Zlokovic, Abhay P. Sagare
Publikováno v:
JCI insight. 5
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with diverse etiologies. Therefore, the identification of common disease mechanisms and therapeutics targeting these mechanisms could dramatically improve clinical outcomes. To this
Autor:
Akimori Wada, Ryutaro Miyagi, Hiroo Imai, Tohru Sugawara, Takashi Okitsu, Mitsuto Aibara, Norihiro Okada, Yohey Terai, Semvua I. Mzighani, Hidenori Tachida
Publikováno v:
Molecular biology and evolution. 29(11)
Reproductive isolation that prevents interspecific hybridization between closely related coexisting species maintains sympatric species diversity. One of the reproductive isolations is mate choice based on color signals (breeding color perceived by c
Autor:
Justin K. Ichida, Takumi Miura, Hidenori Akutsu, Youki Takezawa, Toshio Hamatani, Tohru Sugawara, Naoaki Kuji, Keiichi Yoshida, Noriko Okumura, Kenji Miyado, Akihiro Umezawa, Yasunori Yoshimura, Mitsutoshi Yamada, Akihiro Hosoda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intra