Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Thomas C. Foster"'
Autor:
Philip Alexander, Efron, Dijoia B, Darden, Eric C, Li, Jennifer, Munley, Lauren, Kelly, Brittany, Fenner, Dina C, Nacionales, Ricardo F, Ungaro, Marvin L, Dirain, Jaimar, Rincon, Robert T, Mankowski, Christiaan, Leeuwenburgh, Fredrick A, Moore, Scott C, Brakenridge, Thomas C, Foster, Orlando, Laitano, Gemma, Casadesus, Lyle L, Moldawer, Alicia M, Mohr, Ryan M, Thomas
Publikováno v:
Journal of Trauma and Acute Care Surgery. 93:137-146
Sepsis-induced gut microbiome alterations contribute to sepsis-related morbidity and mortality. Given evidence for improved postsepsis outcomes in females compared with males, we hypothesized that female mice maintain microbiota resilience versus mal
Autor:
Asha Rani, Jolie Barter, Ashok Kumar, Julie A. Stortz, McKenzie Hollen, Dina Nacionales, Lyle L. Moldawer, Philip A. Efron, Thomas C. Foster
Publikováno v:
Aging. 14(2)
Sepsis, defined as a dysregulated host immune response to infection, is a common and dangerous clinical syndrome. The excessive host inflammatory response can induce immediate and persistent cognitive decline, which can be worse in older individuals.
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Autor:
Maisha Akbar, Zhaoyi Chen, Adam J. Woods, Jian-Guo Bian, Andrew O’Shea, Asha Rani, François Modave, Thomas C. Foster, Eric C. Porges, Ronald A. Cohen, Joseph M. Gullett
Publikováno v:
Neurobiol Aging
The expression of micro-RNA (miRNA) is influenced by ongoing biological processes, including aging, and has begun to play a large role in the measurement of neurodegenerative processes in central nervous system. The purpose of this study was to utili
Autor:
Alicia M. Mohr, Marvin L. Dirain, Lyle L. Moldawer, Ashok V. Kumar, Stephanie E. Wohlgemuth, Azra Bihorac, Frederick A. Moore, Marc Segal, McKenzie K. Hollen, Ricardo Ungaro, Scott C. Brakenridge, Hiroyuki Horiguchi, Thomas C. Foster, Christiaan Leeuwenburgh, Kevin K Wu, Philip A. Efron, Quran Wu, Julia A Ross, Brian D. Stewart, Zhongkai Wang, Julie A. Stortz, Dina C. Nacionales
Publikováno v:
Crit Care Med
Objectives Our goal was to "reverse translate" the human response to surgical sepsis into the mouse by modifying a widely adopted murine intra-abdominal sepsis model to engender a phenotype that conforms to current sepsis definitions and follows the
Autor:
Dina C. Nacionales, McKenzie K. Hollen, Lyle L. Moldawer, Julie A. Stortz, Thomas C. Foster, Philip A. Efron, Jolie Barter, Ashok V. Kumar
Publikováno v:
Molecular Neurobiology
Although in-hospital mortality rates for sepsis have decreased, survivors often experience lasting physical and cognitive deficits. Moreover, older adults are more vulnerable to long-term complications associated with sepsis. We employed a murine mod
Autor:
Yenisel Cruz-Almeida, Asha Rani, Soamy Montesino-Goicolea, Zhiguang Huo, Thomas C. Foster, Puja Sinha
Publikováno v:
Molecular Pain
Our study aimed to identify differentially methylated CpGs/regions and their enriched genomic pathways associated with underlying chronic musculoskeletal pain in older individuals. We recruited cognitively healthy older adults with ( n = 20) and with
Publikováno v:
Neurobiology of aging. 49
The expression of estrogen receptor alpha (ERα) varies across brain regions and changes with age and according to the previous history of estradiol exposure. ERα is regulated by a number of mechanisms including the level of mRNA (Esr1) expression.
Autor:
Thomas C. Foster, Puja Sinha, Zhiguang Huo, Roger B. Fillingim, Yenisel Cruz-Almeida, Asha Rani
Publikováno v:
Molecular Pain
Gerontological research reveals considerable interindividual variability in aging phenotypes, which has motivated research efforts to identify “aging biomarkers.” Aging biomarkers are used to calculate biological age, which are better predictors
Autor:
Kristina K. Aenlle, Thomas C. Foster, Asha Rani, Xiaoxia Han, Ashok Kumar, Linda A. Bean, Susan L. Semple-Rowland
Publikováno v:
The Journal of Neuroscience. 33:2671-2683
The expression of the ERα and ERβ estrogen receptors in the hippocampus may be important in the etiology of age-related cognitive decline. To examine the role of ERα and ERβ in regulating transcription and learning, ovariectomized wild-type (WT)