Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Serge Y. Fuchs"'
Autor:
Yongjuan Guan, Huijuan Lin, N Adrian Leu, Gordon Ruthel, Serge Y Fuchs, Luca Busino, Mengcheng Luo, P Jeremy Wang
Publikováno v:
BASE-Bielefeld Academic Search Engine
Homeostasis of meiotic DNA double strand breaks (DSB) is critical for germline genome integrity and homologous recombination. Here we demonstrate an essential role for SKP1, a constitutive subunit of the SCF (SKP1-Cullin-F-box) ubiquitin E3 ligase, i
Publikováno v:
Nucleic Acids Research
Meiotic recombination enables reciprocal exchange of genetic information between parental chromosomes and is essential for fertility. MEIOB, a meiosis-specific ssDNA-binding protein, regulates early meiotic recombination. Here we report that the huma
Autor:
Edith P. Mitchell, Jeffrey A. Hooke, Serge Y. Fuchs, Hallgeir Rui, Yunguang Sun, Albert J. Kovatich, Hai Hu, Pengfei Yu, Olena Odnokoz, Amy R. Peck
Publikováno v:
Cancer Biol Ther
Within the microenvironment of solid tumors, stress associated with deficit of nutrients and oxygen as well as tumor-derived factors triggers the phosphorylation-dependent degradation of the IFNAR1 chain of type I interferon (IFN1) receptor and ensui
Publikováno v:
The Journal of Immunology. 204:2192-2202
Type I and III IFNs play diverse roles in bacterial infections, being protective for some but deleterious for others. Using RNA-sequencing transcriptomics we investigated lung gene expression responses to Bordetella pertussis infection in adult mice,
Autor:
Hemma Murali, Ajeya Nandi, Serge Y. Fuchs, Ratnesh Kumar Srivastava, Sabrina Kim, M. Raza Zaidi, Snahlata Singh, Mario Andres Blanco, Sushil Kumar, Rizwan Saffie, Gatha Thacker, Luca Busino, Mary Baldeon, Rumela Chakrabarti, Satrajit Sinha, John W. Tobias
Publikováno v:
Nat Cell Biol
Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that loss of the tumour suppressive transcription factor Elf5 in TNBC ce
Autor:
Kevin Alicea-Torres, Agnieszka Rynda-Apple, Andrew V. Kossenkov, Jinyun Chen, Shuyu Fu, Emilio Sanseviero, Brian Nam, Qiujin Yu, Dmitry I. Gabrilovich, Serge Y. Fuchs, Fred Denstman, Jun Gui, Gregory A. Masters, Filippo Veglia, Laxminarasimha Donthireddy, Neil Hockstein, Cindy Lin, Charles Mulligan, Joseph R. Bennett, Yulia Nefedova
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils and monocytes with potent immune suppressive activity. These cells play an important role in accelerating tumor progression and undermining the efficacy of anti-cancer t
Autor:
Narayan G. Avadhani, Frank J. Gonzalez, Satish Srinivasan, Anil K. Rustgi, Serge Y. Fuchs, Haider Raza, Anindya Roy Chowdhury, Jyotirmoy Ghosh, Mrittika Chattopadhyay, Sabyasachi Bhattacharya, Moumita Bose
Publikováno v:
Toxicological Sciences.
We previously reported that mitochondrial CYP1 enzymes participate in the metabolism of polycyclic aromatic hydrocarbons and other carcinogens leading to mitochondrial dysfunction. In this study, using Cyp1b1(−)(/)(−), Cyp1a1/1a2(−)(/)(−), an
Autor:
David W. Wilkes, Rumela Chakrabarti, Ratnesh Kumar Srivastav, Taylor Ross, Manti Guha, Jules Kowalski, Qing Zhang, Srinivas Chatla, Serge Y. Fuchs, Sushil Kumar, Anupma Nayak, Sabrina Kim, Christoforos Thomas
Publikováno v:
Oncogene
Aberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of ligand-mediated Notch signaling that promote breast cancer remains elusive. In our studies
Autor:
Angela K Brice, N. Adrian Leu, Anil K. Rustgi, Hallgeir Rui, Bin Zhao, Hui Zheng, Kelly A. McCorkell, Melanie A. Girondo, Shigetsugu Takano, Kanstantsin V. Katlinski, Narayan G. Avadhani, Sabyasachi Bhattacharya, Yuliya V. Katlinskaya, Michael J. May, Serge Y. Fuchs, Qiujing Yu, Satish Srinivasan, Christopher J. Carbone, Maximilian Reichert
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 384-397 (2014)
EMBO Molecular Medicine
EMBO Molecular Medicine
Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitination and d
Autor:
Rong-Bing Guo, Serge Y. Fuchs, Yuliya V. Katlinskaya, Haineng Xu, Kanstantsin V. Katlinski, Xinyuan Liu, Shuai Wu, Lieyang Chen, Fang Xianlong, Kangjian Zhang, Jing Xiao, Xiao-Fei Yin, Xi Jun Liu, Da-Cheng Wang, Hui-Ling Li, Liang Chu, Yuan-Qin Yang, Guang-Wen Wei, Yan-Ni Xu, Sujing Yuan
Purpose: Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I IFNs (IFN1) prompt the design of recombinant IFN1 for therapeutic purposes. However, most of the designed IFNs exhibited suboptimal therapeutic efficacies aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd92768b7d1f5508d47610f6222e352a
https://europepmc.org/articles/PMC5373932/
https://europepmc.org/articles/PMC5373932/