Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sander Barnhoorn"'
Autor:
Simona V. Gornati, Ayse Ulusoy, Donato A. Di Monte, Chiara Milanese, Daniel F. Wallace, Pier Giorgio Mastroberardino, Sander Barnhoorn, Fabio Blandini, Silvia Cerri, V. Nathan Subramaniam, Sylvia Gabriels
Publikováno v:
Cell death and differentiation 28(5), 1720-1732 (2021). doi:10.1038/s41418-020-00698-4
Cell Death and Differentiation
Cell Death and Differentiation, 28(5), 1720-1732. Nature Publishing Group
Cell Death and Differentiation
Cell Death and Differentiation, 28(5), 1720-1732. Nature Publishing Group
Alterations in the metabolism of iron and its accumulation in the substantia nigra pars compacta accompany the pathogenesis of Parkinson’s disease (PD). Changes in iron homeostasis also occur during aging, which constitutes a PD major risk factor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33103840c384a4b784bbebe56a2f5c1
Autor:
Annelieke S. de Wit, Sander Barnhoorn, Mirjam M.C. Wamelink, Renata M. C. Brandt, César Payán-Gómez, Akos Gyenis, Jan H.J. Hoeijmakers, Wilbert P. Vermeij, Pier G. Mastroberardino, André B.P. van Kuilenburg, Donatella Caruso, Sara Sepe, Matteo Audano, René Leen, Roel C. Janssens, Nico Mitro, Cíntia R. Bombardieri, Chiara Milanese, Silvia Pedretti
Publikováno v:
Nature Communications, 10:4887. Nature Publishing Group
Nature Communications
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, 10(1):4887. Nature Publishing Group
Nature Communications, 10(1):4887. Nature Publishing Group
Milanese, C, Bombardieri, C N R, Sepe, S, Barnhoorn, S, Payán-Goméz, C S, Caruso, D, Audano, M, Pedretti, S, Vermeij, W P, Brandt, R M C, Gyenis, A, Wamelink, M M, de Wit, A S, Janssens, R C, Leen, R, van Kuilenburg, A B P, Mitro, N, Hoeijmakers, J H J & Mastroberardino, P G 2019, ' DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering ', Nature Communications, vol. 10, no. 1, 4887 . https://doi.org/10.1038/s41467-019-12640-5
Nature Communications
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature communications, 10(1):4887. Nature Publishing Group
Nature Communications, 10(1):4887. Nature Publishing Group
Milanese, C, Bombardieri, C N R, Sepe, S, Barnhoorn, S, Payán-Goméz, C S, Caruso, D, Audano, M, Pedretti, S, Vermeij, W P, Brandt, R M C, Gyenis, A, Wamelink, M M, de Wit, A S, Janssens, R C, Leen, R, van Kuilenburg, A B P, Mitro, N, Hoeijmakers, J H J & Mastroberardino, P G 2019, ' DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering ', Nature Communications, vol. 10, no. 1, 4887 . https://doi.org/10.1038/s41467-019-12640-5
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign upon genomic instability, h
Autor:
Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole vanVliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Publikováno v:
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 10(3), 662-686. Wiley-Blackwell
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 3, Pp 662-686 (2019)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 3, Pp 662-686 (2019)
Background One of the principles underpinning our understanding of ageing is that DNA damage induces a stress response that shifts cellular resources from growth towards maintenance. A contrasting and seemingly irreconcilable view is that prompting g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f6d56aa0b9c18218f6705ee81fb94033
https://pure.eur.nl/en/publications/c8d9a207-393e-4a46-ab24-48b7ff658537
https://pure.eur.nl/en/publications/c8d9a207-393e-4a46-ab24-48b7ff658537
Autor:
Akos Gyenis, Raoul Kuiper, Sameh A. Youssef, M.E.T. Dollé, Renata M. C. Brandt, C. T. M. Van Oostrom, Wilbert P. Vermeij, Bhawani Nagarajah, B.C.J. van der Eerden, H. van Steeg, Jan Vijg, Dick Jaarsma, A. de Bruin, Cíntia R. Bombardieri, Anton J.M. Roks, Sandra Imholz, Sander Barnhoorn, Joris Pothof, H. Wu, S. M. Botter, Erwin Reiling, César Payán-Gómez, Jan H.J. Hoeijmakers, Jeroen L. A. Pennings
Publikováno v:
Nature, 537(7620), 427-431. Nature Publishing Group
Nature
Nature, 537(7620), 427
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Nature
Nature, 537(7620), 427
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1?/-) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Suc
Autor:
Adriaan A, van Beek, Floor, Hugenholtz, Ben, Meijer, Bruno, Sovran, Olaf, Perdijk, Wilbert P, Vermeij, Renata M C, Brandt, Sander, Barnhoorn, Jan H J, Hoeijmakers, Paul, de Vos, Pieter J M, Leenen, Rudi W, Hendriks, Huub F J, Savelkoul
Publikováno v:
Journal of leukocyte biology. 101(4)
With aging, tryptophan metabolism is affected. Tryptophan has a crucial role in the induction of immune tolerance and the maintenance of gut microbiota. We, therefore, studied the effect of dietary tryptophan restriction in young wild-type (WT) mice
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency
Autor:
Gijsbertus T. J. van der Horst, Ingrid van der Pluijm, Hervé Menoni, Wilbert P. Vermeij, Renata M. C. Brandt, Jan H.J. Hoeijmakers, Sander Barnhoorn, Monique C. de Waard, S.M. Botter, Dick Jaarsma, Priscilla K. Cooper, Altaf H. Sarker, Maria Tresini, Nicolaas G. J. Jaspers, Michael Weymaere, Lieneke M. Uittenboogaard
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004686 (2014)
PLoS Genetics
PLoS genetics, vol 10, iss 10
Barnhoorn, S; Uittenboogaard, LM; Jaarsma, D; Vermeij, WP; Tresini, M; Weymaere, M; et al.(2014). Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency. PLoS Genetics, 10(10). doi: 10.1371/journal.pgen.1004686. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5qz7h7b6
PLoS Genetics, 10(10):e1004686. Public Library of Science
Barnhoorn, S, Uittenboogaard, L M, Jaarsma, D, Vermeij, W P, Tresini, M, Weymaere, M, Menoni, H, Brandt, R M C, de Waard, M C, Botter, S M, Sarker, A H, Jaspers, N G J, van der Horst, G T J, Cooper, P K, Hoeijmakers, J H J & van der Pluijm, I 2014, ' Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency ', PLoS Genetics, vol. 10, no. 10, e1004686 . https://doi.org/10.1371/journal.pgen.1004686
PLoS Genetics (print), 10(10). Public Library of Science
PLoS Genetics
PLoS genetics, vol 10, iss 10
Barnhoorn, S; Uittenboogaard, LM; Jaarsma, D; Vermeij, WP; Tresini, M; Weymaere, M; et al.(2014). Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency. PLoS Genetics, 10(10). doi: 10.1371/journal.pgen.1004686. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5qz7h7b6
PLoS Genetics, 10(10):e1004686. Public Library of Science
Barnhoorn, S, Uittenboogaard, L M, Jaarsma, D, Vermeij, W P, Tresini, M, Weymaere, M, Menoni, H, Brandt, R M C, de Waard, M C, Botter, S M, Sarker, A H, Jaspers, N G J, van der Horst, G T J, Cooper, P K, Hoeijmakers, J H J & van der Pluijm, I 2014, ' Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency ', PLoS Genetics, vol. 10, no. 10, e1004686 . https://doi.org/10.1371/journal.pgen.1004686
PLoS Genetics (print), 10(10). Public Library of Science
As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relatio