Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mickaël Canouil"'
Autor:
Elmar W. Tobi, Diana L. Juvinao-Quintero, Justiina Ronkainen, Raffael Ott, Rossella Alfano, Mickaël Canouil, Madelon L. Geurtsen, Amna Khamis, Leanne K. Küpers, Ives Y. Lim, Patrice Perron, Giancarlo Pesce, Johanna Tuhkanen, Anne P. Starling, Toby Andrew, Elisabeth Binder, Robert Caiazzo, Jerry K.Y. Chan, Romy Gaillard, Peter D. Gluckman, Elina Keikkala, Neerja Karnani, Sanna Mustaniemi, Tim S. Nawrot, François Pattou, Michelle Plusquin, Violeta Raverdy, Kok Hian Tan, Evangelia Tzala, Katri Raikkonen, Christiane Winkler, Anette-G. Ziegler, Isabella Annesi-Maesano, Luigi Bouchard, Yap Seng Chong, Dana Dabelea, Janine F. Felix, Barbara Heude, Vincent W.V. Jaddoe, Jari Lahti, Brigitte Reimann, Marja Vääräsmäki, Amélie Bonnefond, Philippe Froguel, Sandra Hummel, Eero Kajantie, Marjo-Riita Jarvelin, Regine P.M. Steegers-Theunissen, Caitlin G. Howe, Marie-France Hivert, Sylvain Sebert
Publikováno v:
Diabetes Care
Diabetes Care, 2022, 45 (3), pp.614-623. ⟨10.2337/dc21-1701⟩
Diabetes Care, 45(3), 614-623. American Diabetes Association Inc.
Diabetes Care 45, 614-623 (2022)
Diabetes Care, 2022, 45 (3), pp.614-623. ⟨10.2337/dc21-1701⟩
Diabetes Care, 45(3), 614-623. American Diabetes Association Inc.
Diabetes Care 45, 614-623 (2022)
OBJECTIVE Maternal glycemic dysregulation during pregnancy increases the risk of adverse health outcomes in her offspring; a risk thought to be linearly related to maternal hyperglycemia. It is hypothesized that changes in offspring DNA methylation (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bc9777913c3a7ff45f03e99fa4e8e9
https://hal.umontpellier.fr/hal-03676276
https://hal.umontpellier.fr/hal-03676276
Autor:
Elizabeth T. Cirulli, Nicole L. Washington, Mickaël Canouil, Guillaume Charpentier, Emmanuelle Durand, Jean-Michel Borys, Alexandre Bolze, Franck De Graeve, Aurélie Dechaume, David Le Guilcher, Beverley Balkau, Sylvia Franc, Frédéric Allegaert, Ronan Roussel, Emmanuel Vaillant, Philippe Froguel, Gai Elhanan, Stefan Gaget, Joseph J. Grzymski, Loic Yengo, Véronique Dhennin, Amélie Bonnefond, James T. Lu, M Vaxillaire, Mathilde Boissel, Michel Marre, Bénédicte Toussaint
Publikováno v:
Nature Metabolism
Nature Metabolism, Nature Publishing Group, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, Nature Publishing Group, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
Nature Metabolism, 2020, 2 (10), pp.1126-1134. ⟨10.1038/s42255-020-00294-3⟩
International audience; Genome-wide association studies have identified 240 independent loci associated with type 2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast, the genetic diagnosis of monogenic forms of
Autor:
Natalia Pervjakova, Gunn-Helen Moen, Maria-Carolina Borges, Teresa Ferreira, James P Cook, Catherine Allard, Robin N Beaumont, Mickaël Canouil, Gad Hatem, Anni Heiskala, Anni Joensuu, Ville Karhunen, Soo Heon Kwak, Frederick T J Lin, Jun Liu, Sheryl Rifas-Shiman, Claudia H Tam, Wing Hung Tam, Gudmar Thorleifsson, Toby Andrew, Juha Auvinen, Bishwajit Bhowmik, Amélie Bonnefond, Fabien Delahaye, Ayse Demirkan, Philippe Froguel, Kadri Haller-Kikkatalo, Hildur Hardardottir, Sandra Hummel, Akhtar Hussain, Eero Kajantie, Elina Keikkala, Amna Khamis, Jari Lahti, Tove Lekva, Sanna Mustaniemi, Christine Sommer, Aili Tagoma, Evangelia Tzala, Raivo Uibo, Marja Vääräsmäki, Pia M Villa, Kåre I Birkeland, Luigi Bouchard, Cornelia M Duijn, Sarah Finer, Leif Groop, Esa Hämäläinen, Geoffrey M Hayes, Graham A Hitman, Hak C Jang, Marjo-Riitta Järvelin, Anne Karen Jenum, Hannele Laivuori, Ronald C Ma, Olle Melander, Emily Oken, Kyong Soo Park, Patrice Perron, Rashmi B Prasad, Elisabeth Qvigstad, Sylvain Sebert, Kari Stefansson, Valgerdur Steinthorsdottir, Tiinamaija Tuomi, Marie-France Hivert, Paul W Franks, Mark I McCarthy, Cecilia M Lindgren, Rachel M Freathy, Deborah A Lawlor, Andrew P Morris, Reedik Mägi
Publikováno v:
Hum Mol Genet
Pervjakova, N, Moen, G H, Borges, M C, Ferreira, T, Lawlor, D A & Mägi, R 2022, ' Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes ', Human Molecular Genetics, vol. 31, no. 19, ddac050, pp. 3377-3391 . https://doi.org/10.1093/hmg/ddac050
Hum. Mol. Genet. 31, 3377–3391 (2022)
Human Molecular Genetics, 31(19), 3377-3391. Oxford University Press
Human Molecular Genetics
Pervjakova, N, Moen, G H, Borges, M C, Ferreira, T, Lawlor, D A & Mägi, R 2022, ' Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes ', Human Molecular Genetics, vol. 31, no. 19, ddac050, pp. 3377-3391 . https://doi.org/10.1093/hmg/ddac050
Hum. Mol. Genet. 31, 3377–3391 (2022)
Human Molecular Genetics, 31(19), 3377-3391. Oxford University Press
Human Molecular Genetics
Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our
Autor:
Sandra Hummel, Sylvain Sebert, Elina Keikkala, Toby Andrew, Stéphane Lobbens, Marjo-Riitta Järvelin, Evangelia Tzala, Mickaël Canouil, Fabien Delahaye, Philippe Froguel, Marja Vääräsmäki, Sanna Mustaniemi, Amna Khamis, Eero Kajantie, Amélie Bonnefond
Publikováno v:
Diabetes Care
Diabetes Care 44, 1992-1999 (2021)
Diabetes Care 44, 1992-1999 (2021)
OBJECTIVE Gestational diabetes mellitus (GDM) is associated with an increased risk of obesity and insulin resistance in offspring later in life, which might be explained by epigenetic changes in response to maternal hyperglycemic exposure. RESEARCH D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77194f5cf8ef2394da006914f54f8693
https://doi.org/10.2337/figshare.14488899.v1
https://doi.org/10.2337/figshare.14488899.v1
Autor:
Alexandre Pelletier, Arnaud Carrier, Yongmei Zhao, Mickaël Canouil, Mehdi Derhourhi, Emmanuelle Durand, Lionel Berberian-Ferrato, John Greally, Francine Hughes, Philippe Froguel, Amélie Bonnefond, Fabien Delahaye
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7323
Excessive fetal growth is associated with DNA methylation alterations in human hematopoietic stem and progenitor cells (HSPC), but their functional impact remains elusive. We implemented an integrative analysis combining single-cell epigenomics, sing
Autor:
Alexandre C. Pereira, Jie Yao, Makoto Hirata, Ozren Polasek, Dragana Vuckovic, Mariaelisa Graff, Jing Hua Zhao, Michael R. Brown, Xuan Deng, Barbara V. Howard, Vilmundur Gudnason, Tuomo Rankinen, Yuan Shi, Timo A. Lakka, Ulrich Broeckel, Anuradhani Kasturiratne, Eric Boerwinkle, Charles Kooperberg, Hugues Aschard, Stephen S. Rich, Pamela J. Schreiner, Dan E. Arking, Hans J. Grabe, Ilaria Gandin, Mario Sims, Carl D. Langefeld, Yii-Der Ida Chen, Meian He, W. James Gauderman, Bruce M. Psaty, Kent D. Taylor, Tõnu Esko, Olli T. Raitakari, Saima Afaq, Maik Pietzner, Federica Laguzzi, Dennis O. Mook-Kanamori, Gregory P. Wilson, Xiuqing Guo, Jaspal S. Kooner, David R. Jacobs, Yajuan Wang, Raha Pazoki, Wei Zhao, Andres Metspalu, Mary F. Feitosa, Jost B. Jonas, Tin Aung, Tamara B. Harris, Karin Leander, Nancy L. Pedersen, Charles B. Eaton, Sharon L.R. Kardia, Bernardo L. Horta, Candace M. Kammerer, Terrence Forrester, Alexander P. Reiner, Paul W. Franks, Tanika N. Kelly, Igor Rudan, Ruben N. Eppinga, Melissa A. Richard, Colin A. McKenzie, Christine Williams, Christian Gieger, Joseph H. Lee, Brigitte Kühnel, Christopher P. Nelson, Wen Bin Wei, Antonietta Robino, Anne U. Jackson, E. Shyong Tai, Alisa K. Manning, Lisa R. Yanek, Paul Elliott, Lynne E. Wagenknecht, Ananda R. Wickremasinghe, José Eduardo Krieger, Peter S. Sever, Nora Franceschini, André G. Uitterlinden, Paul M. Ridker, Yun J. Sung, Karen L. Mohlke, Thomas H. Mosley, Nilesh J. Samani, Patricia B. Munroe, Jennifer A. Smith, John M. C. Connell, H. Janaka de Silva, Nicholas Y. Q. Tan, Jian'an Luan, Jennifer E. Huffman, Anna F. Dominiczak, Carsten Oliver Schmidt, Christie M. Ballantyne, Peter J. van der Most, Anuj Goel, Jerome I. Rotter, Amy R. Bentley, Lihua Wang, Rajkumar Dorajoo, Lenore J. Launer, Yechiel Friedlander, Mickaël Canouil, Traci M. Bartz, Thomas Meitinger, Robert A. Scott, Mike A. Nalls, Xueling Sim, Sarah E. Harris, Michael A. Province, Chew-Kiat Heng, Zhe Wang, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Virginia Fisher, Leslie J. Raffel, Renée de Mutsert, Michele K. Evans, Brenda W.J.H. Penninx, Yih Chung Tham, Tin Louie, Nana Matoba, Lawrence F. Bielak, Andrea R. V. R. Horimoto, Jingmin Liu, Lynda M. Rose, Nona Sotoodehnia, Daniel I. Chasman, Jasmin Divers, John M. Starr, Patricia A. Peyser, Ervin R. Fox, Barry I. Freedman, Megan L. Grove, Jeffrey R. O'Connell, Rob M. van Dam, Michiaki Kubo, Jessica D. Faul, Fang-Chi Hsu, Yize Li, Ilja M. Nolte, Caroline Hayward, Paolo Gasparini, Chiea Chuen Khor, Changwei Li, Xu Chen, James E. Hixson, Patrik K. E. Magnusson, John C. Chambers, Yoichiro Kamatani, Sami Heikkinen, M. Abdullah Said, Martin Farrall, Alena Stančáková, Konstantin Strauch, Albert V. Smith, Yik Ying Teo, Bamidele O. Tayo, Tamar Sofer, Caizheng Yu, Maris Alver, Oscar H. Franco, Yongmei Liu, Ioanna Ntalla, Myriam Fornage, W. Craig Johnson, Dina Vojinovic, William R. Scott, David R. Weir, Yanick Hagemeijer, Raymond Noordam, Mathilde Boissel, Cornelia M. van Duijn, Karen Schwander, Jingzhong Ding, James Scott, Diana van Heemst, Ching-Yu Cheng, Woon-Puay Koh, Jianjun Liu, Kenneth J. Mukamal, Blair H. Smith, Claude Bouchard, Claudia Langenberg, Jingjing Liang, Wei Zheng, Najaf Amin, Ulf de Faire, Bing Yu, Archie Campbell, Kari E. North, Salman M. Tajuddin, Fernando Pires Hartwig, Steve B. Kritchevsky, Tibor V. Varga, Pirjo Komulainen, Hugh Watkins, Johanna Kuusisto, Kurt Lohman, Rozenn N. Lemaitre, Ani Manichaikul, Dabeeru C. Rao, Kenneth Rice, Weihua Zhang, Franco Giulianini, Reedik Mägi, Solomon K. Musani, Wanqing Wen, Nicholas J. Wareham, Charles N. Rotimi, Marzyeh Amini, Rainer Rauramaa, Nicholette D. Palmer, Annette Peters, Neil R Poulter, Benjamin Lehne, Matthias Nauck, Harold Snieder, Donald W. Bowden, M. Arfan Ikram, Lisa de las Fuentes, C. Charles Gu, Xiaofeng Zhu, Markku Laakso, Tuomas O. Kilpeläinen, Ching-Ti Liu, Michael Boehnke, Jin-Fang Chai, Lili Milani, L. Adrienne Cupples, Yuri Milaneschi, Kiang Liu, Stephen Sidney, Alan B. Zonderman, Thomas W. Winkler, Ian J. Deary, Fumihiko Takeuchi, Mary K. Wojczynski, Pim van der Harst, Leo-Pekka Lyytikäinen, Jennifer G. Robinson, Chuan Gao, Xiao-Ou Shu, Diane M. Becker, Mohsen Ghanbari, Alanna C. Morrison, Jian-Min Yuan, Tomohiro Katsuya, Ivana Kolcic, Melanie Waldenberger, Terho Lehtimäki, Heikki A. Koistinen, Erin B. Ware, Ya Xing Wang, Marie Loh, Treva Rice, Qing Duan, Aldi T. Kraja, Sabanayagam Charumathi, Tien Yin Wong, Paul S. de Vries, Yujie Wang, Muhammad Riaz
Publikováno v:
American Journal of Epidemiology, 188(6), 1033-1054. Oxford University Press
American Journal of Epidemiology, 188(6), 1033-1054. OXFORD UNIV PRESS INC
American Journal of Epidemiology
American Journal of Epidemiology, 2019, 188 (6), pp.1033-1054. ⟨10.1093/aje/kwz005⟩
American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (6), pp.1033-1054. ⟨10.1093/aje/kwz005⟩
2019, ' Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions ', American Journal of Epidemiology . https://doi.org/10.1093/aje/kwz005
American journal of epidemiology, vol 188, iss 6
De Vries, P S, Lifelines Cohort Study, Brown, M R, Bentley, A R, Sung, Y J, Winkler, T W, Ntalla, I, Schwander, K, Kraja, A T, Guo, X, Franceschini, N, Cheng, C Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Deng, X, Dorajoo, R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Evangelou, E, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Gandin, I, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Hsu, F C, Jackson, A U, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Penninx, BWJH & Lifelines Cohort 2019, ' Multiancestry Genome-Wide Association study of lipid levels incorporating gene-alcohol interactions ', American Journal of Epidemiology, vol. 188, no. 6, pp. 1033-1054 . https://doi.org/10.1093/aje/kwz005
Am J Epidemiol
American journal of epidemiology, 188(6), 1033-1054. Oxford University Press
American Journal of Epidemiology, 188(6), 1033-1054. OXFORD UNIV PRESS INC
American Journal of Epidemiology
American Journal of Epidemiology, 2019, 188 (6), pp.1033-1054. ⟨10.1093/aje/kwz005⟩
American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (6), pp.1033-1054. ⟨10.1093/aje/kwz005⟩
2019, ' Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions ', American Journal of Epidemiology . https://doi.org/10.1093/aje/kwz005
American journal of epidemiology, vol 188, iss 6
De Vries, P S, Lifelines Cohort Study, Brown, M R, Bentley, A R, Sung, Y J, Winkler, T W, Ntalla, I, Schwander, K, Kraja, A T, Guo, X, Franceschini, N, Cheng, C Y, Sim, X, Vojinovic, D, Huffman, J E, Musani, S K, Li, C, Feitosa, M F, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Deng, X, Dorajoo, R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Evangelou, E, Graff, M, Alver, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Gandin, I, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, Hartwig, F P, He, M, Horimoto, A R V R, Hsu, F C, Jackson, A U, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Penninx, BWJH & Lifelines Cohort 2019, ' Multiancestry Genome-Wide Association study of lipid levels incorporating gene-alcohol interactions ', American Journal of Epidemiology, vol. 188, no. 6, pp. 1033-1054 . https://doi.org/10.1093/aje/kwz005
Am J Epidemiol
American journal of epidemiology, 188(6), 1033-1054. Oxford University Press
© The Author(s) 2019. A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-Alcohol interactions into a m
Autor:
Agata Wesolowska-Andersen, Caroline A. Brorsson, Roberto Bizzotto, Andrea Mari, Andrea Tura, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Cornelia Prehn, Anna Artati, Mun-Gwan Hong, Petra B. Musholt, Azra Kurbasic, Federico De Masi, Kostas Tsirigos, Helle Krogh Pedersen, Valborg Gudmundsdottir, Cecilia Engel Thomas, Karina Banasik, Chrisopher Jennison, Angus Jones, Gwen Kennedy, Jimmy Bell, Louise Thomas, Gary Frost, Henrik Thomsen, Kristine Allin, Tue Haldor Hansen, Henrik Vestergaard, Torben Hansen, Femke Rutters, Petra Elders, Leen t’Hart, Amelie Bonnefond, Mickaël Canouil, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Andrew Hattersley, Timothy McDonald, Harriet Teare, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Philippe Froguel, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Ewan Pearson, Mark I. McCarthy, Søren Brunak
Publikováno v:
the IMI-DIRECT consortium, Wesolowska-Andersen, A, Brorsson, C A, Bizzotto, R, Mari, A, Tura, A, Koivula, R, Mahajan, A, Vinuela, A, Tajes, J F, Sharma, S, Haid, M, Prehn, C, Artati, A, Hong, M G, Musholt, P B, Kurbasic, A, De Masi, F, Tsirigos, K, Pedersen, H K, Gudmundsdottir, V, Thomas, C E, Banasik, K, Jennison, C, Jones, A, Kennedy, G, Bell, J, Thomas, L, Frost, G, Thomsen, H, Allin, K, Hansen, T H, Vestergaard, H, Hansen, T, Rutters, F, Elders, P, t'Hart, L, Bonnefond, A, Canouil, M, Brage, S, Kokkola, T, Heggie, A, McEvoy, D, Hattersley, A, McDonald, T, Teare, H, Ridderstrale, M, Walker, M, Forgie, I, Giordano, G N, Froguel, P, Pavo, I, Ruetten, H, Pedersen, O, Dermitzakis, E, Franks, P W, Schwenk, J M, Adamski, J, Pearson, E, McCarthy, M I & Brunak, S 2022, ' Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study ', Cell Reports Medicine, vol. 3, no. 1, 100477 . https://doi.org/10.1016/j.xcrm.2021.100477
Cell Reports Medicine
Cell reports. Medicine, 3(1):100477. Cell Press
Wesolowska-Andersen, A, Brorsson, C A, Bizzotto, R, Mari, A, Tura, A, Koivula, R, Mahajan, A, Vinuela, A, Tajes, J F, Sharma, S, Haid, M, Prehn, C, Artati, A, Hong, M G, Musholt, P B, Kurbasic, A, Masi, F D, Tsirigos, K, Pedersen, H K, Gudmundsdottir, V, Thomas, C E, Banasik, K, Jennison, C, Jones, A, Kennedy, G, Bell, J, Thomas, L, Frost, G, Thomsen, H, Allin, K, Hansen, T H, Vestergaard, H, Hansen, T, Rutters, F, Elders, P, t'Hart, L, Bonnefond, A, Canouil, M, Brage, S, Kokkola, T, Heggie, A, McEvoy, D, Hattersley, A, McDonald, T, Teare, H, Ridderstrale, M, Walker, M, Forgie, I, Pedersen, O, Brunak, S & IMI-DIRECT consortium 2022, ' Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals : An IMI DIRECT study ', Cell Reports Medicine, vol. 3, no. 1, 100477 . https://doi.org/10.1016/j.xcrm.2021.100477
IMI DIRECT Consortium 2022, ' Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals : An IMI DIRECT study ', Cell reports. Medicine, vol. 3, no. 1, 100477 . https://doi.org/10.1016/j.xcrm.2021.100477
Cell Reports Medicine, 3(1). ELSEVIER
Cell Reports Medicine
Cell reports. Medicine, 3(1):100477. Cell Press
Wesolowska-Andersen, A, Brorsson, C A, Bizzotto, R, Mari, A, Tura, A, Koivula, R, Mahajan, A, Vinuela, A, Tajes, J F, Sharma, S, Haid, M, Prehn, C, Artati, A, Hong, M G, Musholt, P B, Kurbasic, A, Masi, F D, Tsirigos, K, Pedersen, H K, Gudmundsdottir, V, Thomas, C E, Banasik, K, Jennison, C, Jones, A, Kennedy, G, Bell, J, Thomas, L, Frost, G, Thomsen, H, Allin, K, Hansen, T H, Vestergaard, H, Hansen, T, Rutters, F, Elders, P, t'Hart, L, Bonnefond, A, Canouil, M, Brage, S, Kokkola, T, Heggie, A, McEvoy, D, Hattersley, A, McDonald, T, Teare, H, Ridderstrale, M, Walker, M, Forgie, I, Pedersen, O, Brunak, S & IMI-DIRECT consortium 2022, ' Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals : An IMI DIRECT study ', Cell Reports Medicine, vol. 3, no. 1, 100477 . https://doi.org/10.1016/j.xcrm.2021.100477
IMI DIRECT Consortium 2022, ' Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals : An IMI DIRECT study ', Cell reports. Medicine, vol. 3, no. 1, 100477 . https://doi.org/10.1016/j.xcrm.2021.100477
Cell Reports Medicine, 3(1). ELSEVIER
Summary The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-driven approaches, but their clinical utility may be limited if
Autor:
Cécile Aubert, Maithé Tauber, Ronan Roussel, Bénédicte Toussaint, François Pattou, Philippe Froguel, Jean-Michel Borys, Amjad Ghulam, Hélène Loiselle, Mathilde Boissel, Emmanuelle Durand, Sylvia Franc, Julie Kerr-Conte, Julie Maillet, Morgane Baron, Marlène Huyvaert, Amélie Bonnefond, Raphaël Boutry, J. Philippe, Jérémy Thomas, Guillaume Charpentier, Claire Lévy-Marchal, Michel Marre, Mehdi Derhourhi, Aurélie Dechaume, Emmanuel Vaillant, B. Balkau, Stefan Gaget, Raphael Scharfmann, Jacques Weill, Mickaël Canouil
Publikováno v:
Nature Medicine
Nature Medicine, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature medicine
Nature Medicine, Nature Publishing Group, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature Medicine, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
Nature medicine
Nature Medicine, Nature Publishing Group, 2019, 25 (11), pp.1733-1738. ⟨10.1038/s41591-019-0622-0⟩
International audience; The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor1. Although some MRAP2 mutations have been described in people with obesity1-3, their fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e4070864d7e526bb4fbf52762499c4
https://www.hal.inserm.fr/inserm-02439220/document
https://www.hal.inserm.fr/inserm-02439220/document
Autor:
Ana Ortalli, Marlène Huyvaert, Amélie Bonnefond, Lorella Marselli, Piero Marchetti, Marie Verbanck, Fatou K. Ndiaye, Julie Kerr-Conte, Raphaël Scharfmann, Emmanuelle Durand, Philippe Froguel, Amar Abderrahmani, Mickaël Canouil, Olivier Sand, Vikash Chandra, François Pattou, Raphaël Boutry, Valérie Pawlowski, Odile Poulain-Godefroy, C. Lecoeur, Iandry Rabearivelo, Clara Salazar-Cardozo
Publikováno v:
Molecular Metabolism, Vol 6, Iss 6, Pp 459-470 (2017)
Molecular Metabolism
Molecular Metabolism
Objectives Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments have been dis
Autor:
Niek Verweij, Iva Miljkovic, Peter Vollenweider, Denis Rybin, Aaron Isaacs, Arthur W. Musk, Eero Kajantie, Sara M. Willems, Ronan Roussel, Martina Müller-Nurasyid, Inês Barroso, Beverley Balkau, Stephan J. L. Bakker, Tamara B. Harris, Ching-Ti Liu, Jennie Hui, Letizia Marullo, Joseph Hung, John Beilby, Annette Peters, Cornelia M. van Duijn, Zoltán Kutalik, Kelly S. Benke, Mickaël Canouil, Johan G. Eriksson, Nicole Vogelzangs, James B. Meigs, Loic Yengo, Philippe Froguel, Rico Rueedi, Wolfgang Rathmann, Jennifer L. Bragg-Gresham, Daniel DiCorpo, Maryam Kavousi, Harald Grallert, Chiara Scapoli, Laura J. Rasmussen-Torvik, Jose C. Florez, Pim van der Harst, Nabila Bouatia-Naji, Jordi Merino, Carola Marzi, Tanguy Corre, Alan James, Lyle J. Palmer, Ghislain Rocheleau, Inga Prokopenko, Josée Dupuis, Jari Lahti, Sven Bergmann
Publikováno v:
Scientific Reports, 9:9439. Nature Publishing Group
Scientific Reports
Scientific reports, vol. 9, no. 1, pp. 9439
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Sci. Rep. 9:9439 (2019)
Scientific Reports, 9(1):9439. Nature Publishing Group
Scientific Reports
Scientific reports, vol. 9, no. 1, pp. 9439
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Sci. Rep. 9:9439 (2019)
Scientific Reports, 9(1):9439. Nature Publishing Group
Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we condu