Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joel R. Leininger"'
Autor:
Patricia C. Ryan, Hong Jin, Amy S. Dyke, Kathleen A. Funk, Joel R. Leininger, George Kemble, Christopher Frantz, Rakesh Dixit
Publikováno v:
Toxicologic Pathology. 38:1064-1069
Toxicity studies of intranasally administered, live attenuated influenza virus vaccine candidates conducted in male and female ferrets led to the microscopic observation of individual differences in the size of nasal turbinates, especially in the dor
Publikováno v:
Toxicology and Applied Pharmacology. 148:137-147
Chloroform (TCM), a water disinfection by-product, induced liver tumors in female mice when administered by gavage in corn oil but not when given in drinking water at comparable daily doses. Because short-term studies showed that the gavage doses als
Autor:
Stephane Mery, Brian A. Wong, Michael V. Templin, Byron E. Butterworth, Joel R. Leininger, Jeffrey L. Larson, Kevin T. Morgan, Douglas C. Wolf, Keith C. Jamison
Publikováno v:
Toxicological Sciences. 32:109-125
Chloroform acts via a nongenotoxic–cytotoxic mode of action to produce cancer if given in doses and at dose rates sufficiently high to produce organ-specific toxicity. In a recent study, chloroform failed to induce cancer in male or female F-344 ra
Autor:
Jinhua Yuan, C. W. Jameson, Joel R. Leininger, Thomas J. Goehl, Michael R. Elwell, Morrow B. Thompson, Teresa Carlton, Glenda Corniffe
Publikováno v:
Fundamental and Applied Toxicology. 18:460-470
The application of alpha-cyclodextrin (alpha-CD) as an alternative vehicle for water insoluble and volatile chemicals was investigated in toxicity studies of p-chloro-alpha, alpha, alpha-trifluorotoluene (CTFT). Groups of F344 rats and B6C3F1 mice of
Autor:
R. L. Morrissey, D. D. Dietz, Morrow B. Thompson, Joel R. Leininger, B. S. Levine, Robert E. Chapin, E. J. Rauckman
Publikováno v:
Fundamental and Applied Toxicology. 17:347-360
Two- and thirteen-week toxicity studies were conducted using male and female F344/N rats and B6C3F1 mice. Animals were exposed to the following concentrations of acetone in their drinking water: two-week studies 0; 5000; 10,000; 20,000; 50,000; or 10
Publikováno v:
Toxicologic pathology. 18(4 Pt 2)
Hepatocytes occurred in the stomach as incidental findings in 4 110–112-week-old mice (3 B6C3F1 and 1 Crl:COBS-CD1) sacrificed at termination of 2-yr toxicity/carcinogenicity bioassays of unrelated chemicals. Both sexes, and control and treated ani