Zobrazeno 1 - 10
of 61
pro vyhledávání: '"James P. Allison"'
Autor:
Pavlos Msaouel, Sangeeta Goswami, Peter F. Thall, Xuemei Wang, Ying Yuan, Eric Jonasch, Jianjun Gao, Matthew T. Campbell, Amishi Yogesh Shah, Paul Gettys Corn, Alda L. Tam, Kamran Ahrar, Priya Rao, Kanishka Sircar, Lorenzo Cohen, Sreyashi Basu, Fei Duan, Sonali Jindal, Yuwei Zhang, Hong Chen, Shalini S. Yadav, Ronald Shazer, Hirak Der-Torossian, James P. Allison, Padmanee Sharma, Nizar M. Tannir
Publikováno v:
Science Translational Medicine. 14
The accumulation of immune-suppressive myeloid cells is a critical determinant of resistance to anti–programmed death-1 (PD-1) therapy in advanced clear cell renal cell carcinoma (ccRCC). In preclinical models, the tyrosine kinase inhibitor sitrava
Autor:
Cheuk Hong Leung, Wayne L. Hofstetter, John V. Heymach, Alexandre Reuben, Myrna C.B. Godoy, Ara A. Vaporciyan, Padmanee Sharma, Yasir Elamin, Neda Kalhor, Robert R. Jenq, Junya Fujimoto, Tina Cascone, Anne S. Tsao, William N. William, Charles Lu, Frank E. Mott, Nadim J. Ajami, Don L. Gibbons, Jack A. Roth, David C. Rice, Luisa M. Solis, Hai T. Tran, Brett W. Carter, Lauren Averett Byers, Andrew Futreal, Lorenzo Federico, Annikka Weissferdt, Garrett L. Walsh, Reza J. Mehran, Chantale Bernatchez, George R. Blumenschein, Jennifer A. Wargo, Heather Lin, Cara Haymaker, Xiuning Le, Jonathan M. Kurie, Mehmet Altan, James P. Allison, Stephen G. Swisher, Edwin R. Parra, Boris Sepesi, Hitoshi Dejima, Frank V. Fossella, Jianjun Zhang, Bonnie S. Glisson, Mara B. Antonoff, Abdul Wadud Khan, Apar Pataer, Alejandro Francisco-Cruz, Ignacio I. Wistuba, Humam Kadara, J. Jack Lee, Ferdinandos Skoulidis
Publikováno v:
Nat Med
Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report the results of the phase 2 ran
Autor:
Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, John A. McCulloch, Marie Vetizou, Alexandria P. Cogdill, Md A. Wadud Khan, Xiaotao Zhang, Michael G. White, Christine B. Peterson, Matthew C. Wong, Golnaz Morad, Theresa Rodgers, Jonathan H. Badger, Beth A. Helmink, Miles C. Andrews, Richard R. Rodrigues, Andrey Morgun, Young S. Kim, Jason Roszik, Kristi L. Hoffman, Jiali Zheng, Yifan Zhou, Yusra B. Medik, Laura M. Kahn, Sarah Johnson, Courtney W. Hudgens, Khalida Wani, Pierre-Olivier Gaudreau, Angela L. Harris, Mohamed A. Jamal, Erez N. Baruch, Eva Perez-Guijarro, Chi-Ping Day, Glenn Merlino, Barbara Pazdrak, Brooke S. Lochmann, Robert A. Szczepaniak-Sloane, Reetakshi Arora, Jaime Anderson, Chrystia M. Zobniw, Eliza Posada, Elizabeth Sirmans, Julie Simon, Lauren E. Haydu, Elizabeth M. Burton, Linghua Wang, Minghao Dang, Karen Clise-Dwyer, Sarah Schneider, Thomas Chapman, Nana-Ama A. S. Anang, Sheila Duncan, Joseph Toker, Jared C. Malke, Isabella C. Glitza, Rodabe N. Amaria, Hussein A. Tawbi, Adi Diab, Michael K. Wong, Sapna P. Patel, Scott E. Woodman, Michael A. Davies, Merrick I. Ross, Jeffrey E. Gershenwald, Jeffrey E. Lee, Patrick Hwu, Vanessa Jensen, Yardena Samuels, Ravid Straussman, Nadim J. Ajami, Kelly C. Nelson, Luigi Nezi, Joseph F. Petrosino, P. Andrew Futreal, Alexander J. Lazar, Jianhua Hu, Robert R. Jenq, Michael T. Tetzlaff, Yan Yan, Wendy S. Garrett, Curtis Huttenhower, Padmanee Sharma, Stephanie S. Watowich, James P. Allison, Lorenzo Cohen, Giorgio Trinchieri, Carrie R. Daniel, Jennifer A. Wargo
Publikováno v:
Science (New York, N.Y.). 374(6575)
Another benefit of dietary fiber The gut microbiome can modulate the immune system and influence the therapeutic response of cancer patients, yet the mechanisms underlying the effects of microbiota are presently unclear. Spencer et al . add to our un
Autor:
Joe Y. Chang, Uma Raju, Vivek Subbiah, Ritsuko Komaki, Vassiliki A. Papadimitrakopoulou, Maria Angelica Cortez, George R. Simon, Sherif G. Shaaban, Maria E. Cabanillas, Erminia Massarelli, Padmanee Sharma, Quynh Nhu Nguyen, Hampartsoum B. Barsoumian, Chad Tang, Adi Diab, Hari Menon, James P. Allison, Taylor R. Cushman, Vivek Verma, James W. Welsh, C Anderson, Kenneth R. Hess, John V. Heymach, Aung Naing, Stephen M. Hahn, David S. Hong, Rishab Ramapriyan, Daniel R. Gomez, Kelvin Wang, Patricia M. de Groot, Ramona Dadu
Publikováno v:
Cancer Immunol Res
Ipilimumab is effective for patients with melanoma, but not for those with less immunogenic tumors. We report a phase II trial of ipilimumab with concurrent or sequential stereotactic ablative radiotherapy to metastatic lesions in the liver or lung (
Autor:
Jianjun Gao, Hao Zhao, Rebecca S. S. Tidwell, Emily Z. Keung, Yuji Miura, Salahaldin A. Tahir, Sumit K. Subudhi, Hussein Abdul-Hassan Tawbi, Jennifer A. Wargo, James P. Allison, Padmanee Sharma, Jorge Blando
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22246-22251
Immune checkpoint (IC) therapy provides substantial benefits to cancer patients but can also cause distinctive toxicities termed immune-related adverse events (irAEs). Biomarkers to predict toxicities will be necessary to improve management of patien
Autor:
James P. Allison, Naruhiko Ikoma, Padmanee Sharma, Roberto Carmagnani Pestana, Shalini S. Yadav, Jean Nicolas Vauthey, Jorge Blando, Luis M Vence, Ahmed Kaseb
Publikováno v:
Cancer Immunol Res
In hepatocellular carcinoma (HCC), surgical resection is associated with high recurrence rate, and no effective adjuvant therapy currently exists. We initiated a pilot randomized trial of perioperative immunotherapy with nivolumab and ipilimumab for
Autor:
Catalin Mihalcioiu, Charlotte E. Ariyan, Michael K. Wong, Aurélie Fluckiger, Julie M. Simon, Rossanna C. Pezo, Michael G. White, Padmanee Sharma, Michael A. Postow, Sapna Pradyuman Patel, Adi Diab, Isabella C. Glitza, Elizabeth M. Burton, Whijae Roh, Zachary A. Cooper, Laurence Zitvogel, Maria Paula Roberti, Wen-Jen Hwu, Alexandria P. Cogdill, Miles C. Andrews, Gladys Ferrere, Abdul Wadud Khan, Scott E. Woodman, Robert R. Jenq, Christine N. Spencer, James P. Allison, Lisa Derosa, Curtis Gumbs, Wei Shen Chen, Stephanie S. Watowich, Irina Fernandez Curbelo, Michael A. Davies, Paule Opolon, Connie P.M. Duong, Jennifer A. Wargo, Maryam Tidjani Alou, Courtney W. Hudgens, Vancheswaran Gopalakrishnan, Pierre Olivier Gaudreau, Michael T. Tetzlaff, Didier Raoult, Arielle Elkrief, Khalida Wani, Jeffrey E. Gershenwald, Margaret K. Callahan, Sarah B. Johnson, Alexandre Reuben, Joseph F. Petrosino, Latasha Little, Peter A. Prieto, Matthew Lastrapes, Valerio Iebba, Bertrand Routy, Matthew Adamow, Alexander J. Lazar, Jennifer L. McQuade, Nadim J. Ajami, Golnaz Morad, Rodabe N. Amaria, Matthew C. Wong, Erez N. Baruch, Hussein Abdul-Hassan Tawbi, Satoru Yonekura, Li Zhao, Reetakshi Arora, Luis M Vence, Lauren E. Haydu, Luigi Nezi, Patrick Hwu, P. Andrew Futreal, Jianhua Zhang
Publikováno v:
Nature Medicine
Nature Medicine, 2021, 27 (8), pp.1432-1441. ⟨10.1038/s41591-021-01406-6⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (8), pp.1432-1441. ⟨10.1038/s41591-021-01406-6⟩
Nature Medicine, 2021, 27 (8), pp.1432-1441. ⟨10.1038/s41591-021-01406-6⟩
Nature Medicine, Nature Publishing Group, 2021, 27 (8), pp.1432-1441. ⟨10.1038/s41591-021-01406-6⟩
International audience; Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b68bdb823308a5d01ebdad2aabf30e
https://hal-amu.archives-ouvertes.fr/hal-03333724/file/2f0091ab-846d-4b59-9960-dcea2f6edc58.pdf
https://hal-amu.archives-ouvertes.fr/hal-03333724/file/2f0091ab-846d-4b59-9960-dcea2f6edc58.pdf
Autor:
Moran Amit, Randal S. Weber, Fei Duan, Jennifer A. Wargo, Ying Yuan, Jason M. Johnson, Priyadharsini Nagarajan, Eduardo M. Diaz, M. Laura Rubin, Faye M. Johnson, William H. Morrison, Frank E. Mott, Neil D. Gross, Diana Bell, Jeffrey N. Myers, Bita Esmaeli, Charles Lu, Ryan P. Goepfert, Adel K. El-Naggar, Paul W. Gidley, James P. Allison, Bonnie S. Glisson, Padmanee Sharma, Carol M. Lewis, Renata Ferrarotto, Shalini S. Yadav, Sreyashi Basu, David I. Rosenthal
Publikováno v:
Clin Cancer Res
Purpose: In locoregionally advanced, resectable cutaneous squamous cell carcinoma of the head and neck (CSCC-HN), surgery followed by radiotherapy is standard but can be cosmetically and functionally devastating, and many patients will have recurrenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c1c178490244c1d5a2bbee41339476
https://europepmc.org/articles/PMC8711237/
https://europepmc.org/articles/PMC8711237/
Autor:
Anu Sharma, Sumit K. Subudhi, Jorge Blando, Jorge Scutti, Luis Vence, Jennifer Wargo, James P. Allison, Antoni Ribas, Padmanee Sharma
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 25, iss 4
Purpose: CTLA-4 was the first inhibitory immune checkpoint to be identified. Two mAbs, ipilimumab (IgG1) and tremelimumab (IgG2), which block the function of CTLA-4, have demonstrated durable clinical activity in a subset of patients with advanced so
Autor:
Katherine R. Calvo, Farhad Ravandi, Zainab Al-Hamal, Pallavi Galera, Hagop M. Kantarjian, Jorge E. Cortes, Gheath Alatrash, Patrick Williams, Guillermo Garcia-Manero, Naval Daver, Elias Jabbour, Carlos E. Bueso-Ramos, Karolyn A. Oetjen, Padmanee Sharma, Juliana E. Hidalgo Lopez, Jing Ning, Wilmer Flores, James P. Allison, Christopher S. Hourigan, Marina Konopleva, Steve Kornblau, Michael Andreeff, Sreyashi Basu, Jorge Blando, Lianchun Xiao
Publikováno v:
Cancer
Background Phenotypic characterization of immune cells in the bone marrow (BM) of patients with acute myeloid leukemia (AML) is lacking. Methods T‐cell infiltration was quantified on BM biopsies from 13 patients with AML, and flow cytometry was per