Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eric Fabian"'
Autor:
Peifeng Ren, Felix F. Schmidt, Annika Heckmanns, Mao Wang, Franz Oesch, Anita Samuga, Brandy Riffle, Eric Fabian, Helen Hammer, Robert Landsiedel, Bennard van Ravenzwaay, Oliver Pötz
Publikováno v:
Archives of Toxicology. 94:2663-2682
Xenobiotica-metabolizing enzyme (XME) induction is a relevant biological/biochemical process vital to understanding the toxicological profile of xenobiotics. Early recognition of XME induction potential of compounds under development is therefore imp
Autor:
Franz Oesch, Eric Fabian, Daniela Fruth, Jan G. Hengstler, Franz Ingo Berger, Robert Landsiedel
Publikováno v:
Archives of toxicology, 95(12):3717–3744
Archives of Toxicology
Archives of Toxicology
N-vinyl pyrrolidone (NVP) is produced up to several thousand tons per year as starting material for the production of polymers to be used in pharmaceutics, cosmetics and food technology. Upon inhalation NVP was carcinogenic in the rat, liver tumor fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dba1ca17777a99a3a16d07bef8fea76
https://repository.publisso.de/resource/frl:6432213
https://repository.publisso.de/resource/frl:6432213
Autor:
Eric Fabian, Markus Frericks, Ivana Fegert, Brandy Riffle, Anne E. Loccisano, James S. Bus, B. Bhaskar Gollapudi
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 113
Afidopyropen is an insecticide that acts as a TRPV channel modulator in chordotonal organs of target insects and has been assessed for a wide range of toxicity endpoints including developmental toxicity in rats and rabbits. The GLP developmental toxi
Autor:
Anne E. Loccisano, Brandy Riffle, Markus Frericks, Ivana Fegert, Eric Fabian, Elaine Freeman, Adriana M. Doi
Publikováno v:
Regulatory Toxicology and Pharmacology. 124:104962
Afidopyropen is an insecticide that acts as a transient receptor potential vanilloid subtype (TRPV) channel modulator in chordotonal organs of target insects and has been assessed for a wide range of toxicity endpoints including chronic toxicity and
Autor:
Eric Fabian, Cathy Lester, Nicola J. Hewitt, Andreas Schepky, Martina Klaric, Corie A. Ellison, Richard Cubberley, Carine Jacques-Jamin, Ian Sorrell, Camille Genies, Joan Eilstein, Helga Rothe, Julien Fernandez, Daniela Lange, Sébastien Grégoire, Hélène Duplan
Publikováno v:
Journal of Applied Toxicology
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic‐relevant chemicals. The penetration of finite doses (10 μL/cm2) of chemicals was measured over 24 hours. The dermal delivery (DD) (amount i
Autor:
Hequn Li, Eric Fabian, Xinyi Wang, Bennard van Ravenzwaay, Franziska Engel, Robert Landsiedel
Publikováno v:
Toxicology in Vitro, 33, 174-179
Toxicology in Vitro 33 (2016)
Toxicology in Vitro 33 (2016)
In order to assess whether the placental metabolism of xenobiotic compounds should be taken into consideration for physiologically-based toxicokinetic (PBTK) modelling, the activities of seven phase I and phase II enzymes have been quantified in the
Autor:
Bennard van Ravenzwaay, Barbara Birk, Caroline Gomes, Rene Zbranek, Tabitha Williford, Christian Haase, Tzutzuy Ramirez Hernandez, Robert Landsiedel, Eric Fabian
Publikováno v:
Archives of toxicology. 93(2)
While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay concentrations may misrepresent potential in vivo effects and do not provide dose–response data which can be used for a risk assessment. We used reverse dosimet
Publikováno v:
Archives of Toxicology, 92(3), 1075-1088
Archives of Toxicology 92 (2018) 3
Archives of Toxicology
Archives of Toxicology 92 (2018) 3
Archives of Toxicology
Physiologically based kinetic (PBK) modelling-based reverse dosimetry is a promising tool for the prediction of in vivo developmental toxicity using in vitro concentration–response data. In the present study, the potential of this approach to predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c83ea63d489ace69d5843d7d8d279c
https://research.wur.nl/en/publications/towards-a-generic-physiologically-based-kinetic-model-to-predict-
https://research.wur.nl/en/publications/towards-a-generic-physiologically-based-kinetic-model-to-predict-
Autor:
Markus Frericks, Andrew Van Cott, Bennard van Ravenzwaay, Eric Fabian, Charles Hastings, Burkhard Flick, Naveed Honarvar
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 95
Afidopyropen is a novel insecticide that acts as a TRPV channel modulator in chordotonal organs of target insects. In two carcinogenicity studies with Fischer rats, an increased incidence of uterine adenocarcinomas was observed at 1000 and 3000 ppm.
Publikováno v:
Toxicology in Vitro. 29(1):113-123
Skin absorption testing in vitro is a regulatory accepted alternative method (OECD Guideline 428). Different tests can be applied to evaluate the integrity of the skin samples. Here, we compared the pre- or post-run integrity tests (transepidermal el