Zobrazeno 1 - 10
of 66
pro vyhledávání: '"David E. Housman"'
Autor:
Jiang Chen, Anna M. Westermark, Lewis C. Cantley, Rakesh K. Jain, Brendan Prideaux, John M. Asara, Clary B. Clish, David P. Kodack, Neal I. Lindeman, Christopher W. Ng, Gino B. Ferraro, Ivy X. Chen, Costas A. Lyssiotis, Keene L. Abbott, Ahmed Ali, Jens Nielsen, Zohreh Amoozgar, Dai Fukumura, Raphael Ferreira, Dan G. Duda, Mark Duquette, David E. Housman, Jessica M. Possada, Véronique Dartois, Kamila Naxerova, Shawn M. Davidson, Xin Jin, Matthew G. Vander Heiden, Sylvie Roberge, Todd R. Golub, Amy Deik, Christopher R. Chin, Divya Bezwada, Elena F. Brachtel, Alba Luengo, Landry Blanc
Publikováno v:
Nature Cancer. 2:414-428
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy resistance. Nutrient availability c
Autor:
John W. Day, Sam Sedehizadeh, Thomas A. Cooper, Charles A. Thornton, Christopher B. Burge, Daniel J. Treacy, Thomas T. Wang, David E. Housman, Katy Eichinger, Amanda J. Ward, J. Andrew Berglund, Adam J. Struck, Kirti Bhatt, Joseph Estabrook, Eric T. Wang, David Brook, Hailey Olafson, Tony Westbrook
Publikováno v:
Human Molecular Genetics. 28:1312-1321
Myotonic dystrophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsatellite repeats. Characterized by symptoms in muscle, heart and central nervous system, among others, it is one of the most variable disea
Publikováno v:
Elsevier
We present the case of an HIV-negative patient clinically diagnosed with relapsing-remitting MS who achieved significant disease improvement on Combivir (zidovudine/lamivudine). Within months of treatment, the patient reported complete resolution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3bbe72f1d04866ef0e04000096fc09
https://europepmc.org/articles/PMC6100748/
https://europepmc.org/articles/PMC6100748/
Autor:
Paolo Paganetti, Etienne Régulier, David E. Housman, Vanita Chopra, Ruth A. Bodner, Dorothee Abramowski, Graeme Bilbe, Scott Zeitlin, Corinna Klein, Jonathan H. Fox, Kimberly B. Kegel, Marian DiFiglia, Andreas Weiss, Steven M. Hersch, Muriel Stefani, Stephan Grueninger, H. Diana Rosas, Miriam Bibel
Publikováno v:
Analytical Biochemistry. 395:8-15
The genetic mutation causing Huntington's disease is a polyglutamine expansion in the huntingtin protein where more than 37 glutamines cause disease by formation of toxic intracellular fragments, aggregates, and cell death. Despite a clear pathogenic
Autor:
David E. Housman, Nancy S. Wexler, S.R. Snodgrass, Steven M. Hersch, H. D. Rosas, D Brocklebank, Stacey S. Cherny, Lon R. Cardon, J. B. Penney, Maria A. Ramos-Arroyo, S A Roberts, Jang-Ho J. Cha, J M Andresen, Javier Gayán, Andrew Feigin, Anne B. Young
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :425-429
The instability of the CAG repeat size of the HD gene when transmitted intergenerationally has critical implications for genetic counseling practices. In particular, CAG repeats between 27 and 35 have been the subject of debate based on small samples
Autor:
Alyson Kelley-Hedgepeth, Inga Peter, Michael E. Mendelsohn, Gordon S. Huggins, Emelia J. Benjamin, David E. Housman, Joseph A. Vita, Gary F. Mitchell, Ramachandran S. Vasan, Daniel Levy
Publikováno v:
Journal of human hypertension
PMC
PMC
available in PMC 2010 April 1.
Increased arterial stiffness and wave reflection have been identified as cardiovascular disease risk factors. In light of significant sex differences and the moderate heritability of vascular function measures, we
Increased arterial stiffness and wave reflection have been identified as cardiovascular disease risk factors. In light of significant sex differences and the moderate heritability of vascular function measures, we
Autor:
Gordon S. Huggins, Caroline S. Fox, Richard H. Karas, Michael E. Mendelsohn, David E. Housman, L. Adrienne Cupples, Joanne M. Murabito, Inga Peter, Daniel Levy, Alyson Kelley-Hedgepeth
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2779-2785
Younger age at the onset of menopause and lower circulating levels of estrogen are risk factors for cardiovascular disease. Several studies have detected associations between variations in genes encoding estrogen receptors alpha (ESR1) and beta (ESR2
Autor:
Daniel Cox, Kevin E. Kip, Michael E. Mendelsohn, Alyson Kelley-Hedgepeth, Gordon S. Huggins, Sophia Kogan, Jose M. Ordovas, Maria Claudia Montefusco, Steven E. Reis, Daniel Levy, Inga Peter, David E. Housman
Publikováno v:
Journal of Human Hypertension. 22:512-515
Genetic polymorphisms that influence smooth muscle cell contraction and relaxation may affect the response to anti-hypertensive therapy. Our finding of lower blood pressure (BP) in the setting of treatment for hypertension, particularly with beta-blo
Autor:
Peter Waldmeier, Jonathan H. Fox, Anne B. Young, Aleksey G. Kazantsev, Greg Lieberman, Vanita Chopra, Steven M. Hersch, David E. Housman, Wayne R. Matson, Kathryn Dorsey
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16685-16689
Huntington's disease (HD) is a progressive neurodegenerative disease caused by a glutamine expansion within huntingtin protein. The exact pathological mechanisms determining disease onset and progression remain unclear. However, aggregates of insolub
Autor:
Michael E. Mendelsohn, Amanda M. Shearman, Inga Peter, Emelia J. Benjamin, Richard D. Patten, Richard H. Karas, Gordon S. Huggins, Arthur Pollak, Serkalem Demissie, David E. Housman, Christopher H. Schmid, L. Adrienne Cupples, Ramachandran S. Vasan
Publikováno v:
Hypertension. 49:1000-1006
Left ventricular (LV) mass and other LV measures have been shown to be heritable. In this study we hypothesized that functional variation in the gene coding for estrogen receptor-α ( ESR1 ), known for mediating the effect of estrogens on myocardium,