Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cory Abate-Shen"'
Autor:
Cory Abate-Shen, Amir Lankarani, Matteo Di Bernardo, Michael M. Shen, Rivka L. Shoulson, Soonbum Park, Lijie Rong, Tomasz Owczarek, Talal Syed, Hikmat Al-Ahmadie, David B. Solit, James M. McKiernan, Chee-Wai Chua, Prithi Chakrapani, Jaime Y. Kim
Publikováno v:
Cancer Res
To study the progression of bladder cancer from non–muscle-invasive to muscle-invasive disease, we have developed a novel toolkit that uses complementary approaches to achieve gene recombination in specific cell populations in the bladder urotheliu
Autor:
Charles G. Drake, Cory Abate-Shen, Guarionex Joel DeCastro, Max M. Kates, Renu K. Virk, Christopher B. Anderson, Bridget James, Wilson Sui, Dara Holder, Jamie S. Pak, Shing M. Lee, James M. McKiernan
Publikováno v:
The Journal of urology. 204(2)
For patients with bacillus Calmette-Guérin unresponsive or recurrent/relapsing nonmuscle invasive bladder cancer, multi-agent intravesical trials have been limited. In this study we investigate the safety of intravesical cabazitaxel, gemcitabine and
Autor:
Cory Abate-Shen, Lukas E. Dow, Amanda Kulick, Corina Amor, Nelson R. Salgado, Marcus Ruscetti, Teng Han, Philip A. Watson, Kaloyan M. Tsanov, Zhen Cao, Leah Zamechek, Yu-Jui Ho, Judith Feucht, Charles L. Sawyers, Francisco M. Barriga, Sha Tian, Min Zou, Wassim Abida, John E. Wilkinson, Elisa de Stanchina, Francisco J. Sánchez-Rivera, Scott W. Lowe, Josef Leibold, Katarzyna Rybczyk, Timour Baslan
Publikováno v:
Cancer Discov
To study genetic factors influencing the progression and therapeutic responses of advanced prostate cancer, we developed a fast and flexible system that introduces genetic alterations relevant to human disease directly into the prostate glands of mic
Autor:
Rugang Zhang, Bo Zhao, Nail Fatkhutdinov, Cory Abate-Shen, Ronny Drapkin, Qin Liu, Takeshi Fukumoto, Jianhuang Lin, Lijie Rong, Mark E. Borowsky, Stephanie Jean, Joseph A. Zundell, Shuai Wu, Andrew V. Kossenkov, Mark G. Cadungog, Zhong Deng, Paul M. Lieberman
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates
Autor:
Suk Hyung Lee, Hikmat Al-Ahmadie, Alanna B. Williams, James M. McKiernan, Cory Abate-Shen, Wenhuo Hu, Mitchell C. Benson, Mark V. Silva, Barry S. Taylor, Kwanghee Kim, Eugene J. Pietzak, Sarah K. Bergren, La Mont J. Barlow, Christopher B. Anderson, Jonathan A. Coleman, Cyriac Kandoth, David B. Solit, Michael M. Shen, Justin T. Matulay, Chee Wai Chua, Tomasz Owczarek
Publikováno v:
Cell. 173(2)
Summary Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulate
Autor:
Drew M. Pardoll, Cory Abate-Shen, Charles L. Sawyers, Theodore S. Lawrence, Christopher I. Li, George J. Weiner, Anna D. Barker, Elaine R. Mardis, Nathan A. Berger, George C. Prendergast, Kenneth C. Anderson, Ahmedin Jemal, José Baselga, Peter J. Neumann, John C. Reed, Margaret Foti
Publikováno v:
Clinical Cancer Research. 19:S1-S98
AACR Staff ![Figure][1] On April 8, 2013, in an unprecedented effort to highlight the critical importance of biomedical research, the American Association for Cancer Research (AACR) joined with more than 200 organizations representing a broad spectru
Publikováno v:
Oncotarget
There is a critical need to identify treatment options for patients at high risk for developing muscle invasive bladder cancer that avoid surgical removal of the bladder (cystectomy). In the current study, we have performed preclinical studies to inv
Autor:
Cory Abate-Shen, David M. Berman, Nishita Desai, Philip A. Beachy, Sunil S. Karhadkar, Melissa Reynon, Michael M. Shen, Xi Wang
Publikováno v:
Developmental Biology. 267:387-398
Previous studies have demonstrated that the Hedgehog (Hh) signaling pathway plays a critical role in the development and patterning of many endodermally derived tissues. We have investigated the role of Sonic hedgehog (Shh) in formation of the prosta
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
During development, patterning and morphogenesis of tissues are intimately coordinated through control of cellular proliferation and differentiation. We describe a mechanism by which vertebrate Msx homeobox genes inhibit cellular differentiation by r
Publikováno v:
Molecular and Cellular Biology. 20:661-671
Despite their significance for mammalian embryogenesis, the molecular mechanisms that regulate placental growth and development have not been well defined. The Esx1 homeobox gene is of particular interest because it is among the few regulatory genes