Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Colm O'Dushlaine"'
Autor:
David J. Carey, Cristen J. Willer, Anthony Marcketta, Claudia Schurmann, Leland Barnard, John Penn, Suganthi Balasubramanian, Daren Liu, Joseph B. Leader, Gonçalo R. Abecasis, Marcus B. Jones, John C. Whittaker, Ashutosh K. Pandey, Ida Surakka, David H. Ledbetter, Evan Maxwell, John D. Overton, Andrew Blumenfeld, Michael N. Cantor, Robert A. Scott, Wendy K. Chung, Alexander H. Li, Alexander Lopez, Joshua D. Backman, Matthew R. Nelson, Jeffrey Staples, Giovanni Coppola, Jonathan Marchini, Xiaodong Bai, Kavita Praveen, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Aris N. Economides, Shareef Khalid, William J Salerno, Bin Ye, Cristopher V. Van Hout, Kristian Hveem, Jeffrey G. Reid, Colm O'Dushlaine, Joshua D. Hoffman, Laura M. Yerges-Armstrong, Nilanjana Banerjee, Sean O'Keeffe, Ioanna Tachmazidou, Lon R. Cardon, Alicia Hawes, Aris Baras, Ashish Yadav, George D. Yancopoulos, Lukas Habegger
Publikováno v:
Nature
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world1. Here we describe the release of exome-sequence data for the first 49,960 study
Autor:
Gabriëlla A.M. Blokland, Jakob Grove, Chia-Yen Chen, Chris Cotsapas, Stuart Tobet, Robert Handa, David St Clair, Todd Lencz, Bryan J. Mowry, Sathish Periyasamy, Murray J. Cairns, Paul A. Tooney, Jing Qin Wu, Brian Kelly, George Kirov, Patrick F. Sullivan, Aiden Corvin, Brien P. Riley, Tõnu Esko, Lili Milani, Erik G. Jönsson, Aarno Palotie, Hannelore Ehrenreich, Martin Begemann, Agnes Steixner-Kumar, Pak C. Sham, Nakao Iwata, Daniel R. Weinberger, Pablo V. Gejman, Alan R. Sanders, Joseph D. Buxbaum, Dan Rujescu, Ina Giegling, Bettina Konte, Annette M. Hartmann, Elvira Bramon, Robin M. Murray, Michele T. Pato, Jimmy Lee, Ingrid Melle, Espen Molden, Roel A. Ophoff, Andrew McQuillin, Nicholas J. Bass, Rolf Adolfsson, Anil K. Malhotra, Nicholas G. Martin, Janice M. Fullerton, Philip B. Mitchell, Peter R. Schofield, Andreas J. Forstner, Franziska Degenhardt, Sabrina Schaupp, Ashley L. Comes, Manolis Kogevinas, José Guzman-Parra, Andreas Reif, Fabian Streit, Lea Sirignano, Sven Cichon, Maria Grigoroiu-Serbanescu, Joanna Hauser, Jolanta Lissowska, Fermin Mayoral, Bertram Müller-Myhsok, Beata Świątkowska, Thomas G. Schulze, Markus M. Nöthen, Marcella Rietschel, John Kelsoe, Marion Leboyer, Stéphane Jamain, Bruno Etain, Frank Bellivier, John B. Vincent, Martin Alda, Claire O’Donovan, Pablo Cervantes, Joanna M. Biernacka, Mark Frye, Susan L. McElroy, Laura J. Scott, Eli A. Stahl, Mikael Landén, Marian L. Hamshere, Olav B. Smeland, Srdjan Djurovic, Arne E. Vaaler, Ole A. Andreassen, Bernhard T. Baune, Tracy Air, Martin Preisig, Rudolf Uher, Douglas F. Levinson, Myrna M. Weissman, James B. Potash, Jianxin Shi, James A. Knowles, Roy H. Perlis, Susanne Lucae, Dorret I. Boomsma, Brenda W.J.H. Penninx, Jouke-Jan Hottenga, Eco J.C. de Geus, Gonneke Willemsen, Yuri Milaneschi, Henning Tiemeier, Hans J. Grabe, Alexander Teumer, Sandra Van der Auwera, Uwe Völker, Steven P. Hamilton, Patrik K.E. Magnusson, Alexander Viktorin, Divya Mehta, Niamh Mullins, Mark J. Adams, Gerome Breen, Andrew M. McIntosh, Cathryn M. Lewis, David M. Hougaard, Merete Nordentoft, Ole Mors, Preben B. Mortensen, Thomas Werge, Thomas D. Als, Anders D. Børglum, Tracey L. Petryshen, Jordan W. Smoller, Jill M. Goldstein, Stephan Ripke, Benjamin M. Neale, James T.R. Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Hailiang Huang, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Richard A. Belliveau, Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberly D. Chambert, Raymond C.K. Chan, Ronald Y.L. Chen, Eric Y.H. Chen, Wei Cheng, Eric F.C. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Jurgen Del Favero, Ditte Demontis, Dimitris Dikeos, Timothy Dinan, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan Eriksson, Valentina Escott-Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Paola Giusti-Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, Vera Golimbet, Srihari Gopal, Jacob Gratten, Lieuwe de Haan, Christian Hammer, Mark Hansen, Thomas Hansen, Vahram Haroutunian, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, Masashi Ikeda, Inge Joa, Antonio Julià, René S. Kahn, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Janis Klovins, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Hana Kuzelova-Ptackova, Anna K. Kähler, Claudine Laurent, Jimmy Lee Chee Keong, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung-Yee Liang, Jeffrey Lieberman, Svetlana Limborska, Carmel M. Loughland, Jan Lubinski, Jouko Lönnqvist, Milan Macek, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Sandra Meier, Carin J. Meijer, Bela Melegh, Raquelle I. Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Vihra Milanova, Younes Mokrab, Derek W. Morris, Kieran C. Murphy, Inez Myin-Germeys, Mari Nelis, Igor Nenadic, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Nikitina-Zake, Laura Nisenbaum, Annelie Nordin, Eadbhard O’Callaghan, Colm O’Dushlaine, F. Anthony O’Neill, Sang-Yun Oh, Ann Olincy, Line Olsen, Jim Van Os, Christos Pantelis, George N. Papadimitriou, Sergi Papiol, Elena Parkhomenko, Tiina Paunio, Milica Pejovic-Milovancevic, Diana O. Perkins, Olli Pietiläinen, Jonathan Pimm, Andrew J. Pocklington, John Powell, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Ulrich Schall, Christian R. Schubert, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Engilbert Sigurdsson, Teimuraz Silagadze, Jeremy M. Silverman, Kang Sim, Petr Slominsky, Hon-Cheong So, Chris C.A. Spencer, Hreinn Stefansson, Stacy Steinberg, Elisabeth Stogmann, Richard E. Straub, Eric Strengman, Jana Strohmaier, T. Scott Stroup, Mythily Subramaniam, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Erik Söderman, Srinivas Thirumalai, Draga Toncheva, Sarah Tosato, Juha Veijola, John Waddington, Dermot Walsh, Dai Wang, Qiang Wang, Bradley T. Webb, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Stephanie Williams, Stephanie H. Witt, Aaron R. Wolen, Emily H.M. Wong, Brandon K. Wormley, Hualin Simon Xi, Clement C. Zai, Xuebin Zheng, Fritz Zimprich, Naomi R. Wray, Kari Stefansson, Peter M. Visscher, Douglas H.R. Blackwood, Ariel Darvasi, Enrico Domenici, Michael Gill, Hugh Gurling, Christina M. Hultman, Assen V. Jablensky, Kenneth S. Kendler, Jo Knight, Qingqin S. Li, Jianjun Liu, Steven A. McCarroll, Jennifer L. Moran, Michael J. Owen, Carlos N. Pato, Danielle Posthuma, Pamela Sklar, Jens R. Wendland, Mark J. Daly, Michael C. O’Donovan, Peter Donnelly, Ines Barroso, Jenefer M. Blackwell, Matthew A. Brown, Juan P. Casas, Panos Deloukas, Audrey Duncanson, Janusz Jankowski, Hugh S. Markus, Christopher G. Mathew, Colin N.A. Palmer, Robert Plomin, Anna Rautanen, Stephen J. Sawcer, Richard C. Trembath, Ananth C. Viswanathan, Nicholas W. Wood, Gavin Band, Céline Bellenguez, Colin Freeman, Eleni Giannoulatou, Garrett Hellenthal, Richard Pearson, Matti Pirinen, Amy Strange, Zhan Su, Damjan Vukcevic, Cordelia Langford, Hannah Blackburn, Suzannah J. Bumpstead, Serge Dronov, Sarah Edkins, Matthew Gillman, Emma Gray, Rhian Gwilliam, Naomi Hammond, Sarah E. Hunt, Alagurevathi Jayakumar, Jennifer Liddle, Owen T. McCann, Simon C. Potter, Radhi Ravindrarajah, Michelle Ricketts, Avazeh Tashakkori-Ghanbaria, Matthew Waller, Paul Weston, Pamela Whittaker, Sara Widaa, Mark I. McCarthy, Maria J. Arranz, Steven Bakker, Stephan Bender, Benedicto Crespo-Facorro, Jeremy Hall, Conrad Iyegbe, Stephen Lawrie, Kuang Lin, Don H. Linszen, Ignacio Mata, Muriel Walshe, Matthias Weisbrod, Durk Wiersma, Vassily Trubetskoy, Yunpeng Wang, Jonathan R.I. Coleman, Héléna A. Gaspar, Christiaan A. de Leeuw, Jennifer M. Whitehead Pavlides, Maciej Trzaskowski, Enda M. Byrne, Liam Abbott, Huda Akil, Diego Albani, Ney Alliey-Rodriguez, Adebayo Anjorin, Verneri Antilla, Swapnil Awasthi, Judith A. Badner, Marie Bækvad-Hansen, Jack D. Barchas, Nicholas Bass, Michael Bauer, Richard Belliveau, Carsten Bøcker Pedersen, Erlend Bøen, Marco P. Boks, James Boocock, Monika Budde, William Bunney, Margit Burmeister, Jonas Bybjerg-Grauholm, Miquel Casas, Felecia Cerrato, Kimberly Chambert, Alexander W. Charney, Danfeng Chen, Claire Churchhouse, Toni-Kim Clarke, William Coryell, David W. Craig, Cristiana Cruceanu, Piotr M. Czerski, Anders M. Dale, Simone de Jong, Jurgen Del-Favero, J. Raymond DePaulo, Amanda L. Dobbyn, Ashley Dumont, Torbjørn Elvsåshagen, Chun Chieh Fan, Sascha B. Fischer, Matthew Flickinger, Tatiana M. Foroud, Liz Forty, Christine Fraser, Katrin Gade, Diane Gage, Julie Garnham, Claudia Giambartolomei, Marianne Giørtz Pedersen, Jaqueline Goldstein, Scott D. Gordon, Katherine Gordon-Smith, Elaine K. Green, Melissa J. Green, Tiffany A. Greenwood, Weihua Guan, Martin Hautzinger, Urs Heilbronner, Maria Hipolito, Dominic Holland, Laura Huckins, Jessica S. Johnson, Radhika Kandaswamy, Robert Karlsson, Sarah Kittel-Schneider, Anna C. Koller, Ralph Kupka, Catharina Lavebratt, Jacob Lawrence, William B. Lawson, Markus Leber, Phil H. Lee, Shawn E. Levy, Jun Z. Li, Chunyu Liu, Anna Maaser, Donald J. MacIntyre, Pamela B. Mahon, Lina Martinsson, Steve McCarroll, Peter McGuffin, Melvin G. McInnis, James D. McKay, Helena Medeiros, Sarah E. Medland, Fan Meng, Grant W. Montgomery, Thomas W. Mühleisen, Hoang Nguyen, Caroline M. Nievergelt, Annelie Nordin Adolfsson, Evaristus A. Nwulia, Claire O'Donovan, Loes M. Olde Loohuis, Anil P.S. Ori, Lilijana Oruc, Urban Ösby, Amy Perry, Andrea Pfennig, Eline J. Regeer, Céline S. Reinbold, John P. Rice, Fabio Rivas, Margarita Rivera, Euijung Ryu, Cristina Sánchez-Mora, Alan F. Schatzberg, William A. Scheftner, Nicholas J. Schork, Cynthia Shannon Weickert, Tatyana Shehktman, Paul D. Shilling, Claire Slaney, Janet L. Sobell, Christine Søholm Hansen, Anne T. Spijker, Michael Steffens, John S. Strauss, Szabolcs Szelinger, Robert C. Thompson, Thorgeir E. Thorgeirsson, Jens Treutlein, Helmut Vedder, Weiqing Wang, Stanley J. Watson, Thomas W. Weickert, Simon Xi, Wei Xu, Allan H. Young, Peter Zandi, Peng Zhang, Sebastian Zöllner, Abdel Abdellaoui, Tracy M. Air, Till F.M. Andlauer, Silviu-Alin Bacanu, Aartjan T.F. Beekman, Elisabeth B. Binder, Julien Bryois, Henriette N. Buttenschøn, Na Cai, Enrique Castelao, Jane Hvarregaard Christensen, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Gregory E. Crawford, Gail Davies, Ian J. Deary, Eske M. Derks, Nese Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Jerome C. Foo, Fernando S. Goes, Lynsey S. Hall, Thomas F. Hansen, Ian B. Hickie, Georg Homuth, Carsten Horn, David M. Howard, Marcus Ising, Rick Jansen, Ian Jones, Lisa A. Jones, Eric Jorgenson, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Dean F. MacKinnon, Robert M. Maier, Jonathan Marchini, Hamdi Mbarek, Patrick McGrath, Christel M. Middeldorp, Evelin Mihailov, Francis M. Mondimore, Sara Mostafavi, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O'Reilly, Hogni Oskarsson, Jodie N. Painter, Roseann E. Peterson, Wouter J. Peyrot, Giorgio Pistis, Jorge A. Quiroz, Per Qvist, Saira Saeed Mirza, Robert Schoevers, Eva C. Schulte, Ling Shen, Stanley I. Shyn, Grant C.B. Sinnamon, Johannes H. Smit, Daniel J. Smith, Katherine E. Tansey, Henning Teismann, Wesley Thompson, Pippa A. Thomson, Matthew Traylor, André G. Uitterlinden, Daniel Umbricht, Albert M. van Hemert, Shantel Marie Weinsheimer, Jürgen Wellmann, Yang Wu, Hualin S. Xi, Jian Yang, Futao Zhang, Volker Arolt, Klaus Berger, Udo Dannlowski, Katharina Domschke, Caroline Hayward, Andrew C. Heath, Stefan Kloiber, Glyn Lewis, Pamela AF. Madden, Patrik K. Magnusson, Preben Bo Mortensen, Michael C. O'Donovan, Sara A. Paciga, Nancy L. Pedersen, David J. Porteous, Catherine Schaefer, Henry Völzke, Marco Bortolato, Janita Bralten, Cynthia M. Bulik, Christie L. Burton, Caitlin E. Carey, Lea K. Davis, Laramie E. Duncan, Howard J. Edenberg, Lauren Erdman, Stephen V. Faraone, Slavina B. Goleva, Wei Guo, Christopher Hübel, Laura M. Huckins, Ekaterina A. Khramtsova, Joanna Martin, Carol A. Mathews, Elise Robinson, Eli Stahl, Barbara E. Stranger, Michela Traglia, Raymond K. Walters, Lauren A. Weiss, Stacey J. Winham, Yin Yao, Kristjar Skajaa, Markus Nöthen, Michael Owen, Robert H. Yolken, Niels Plath, Jonathan Mill, Daniel Geschwind
Publikováno v:
Biological Psychiatry, 91(1), 102-117. Elsevier Science
Biological Psychiatry, 91(1), 102-117. Elsevier USA
Blokland, G A M, Grove, J, Chen, C Y, Cotsapas, C, Tobet, S, Handa, R, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH 2022, ' Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders ', Biological Psychiatry, vol. 91, no. 1, pp. 102-117 . https://doi.org/10.1016/j.biopsych.2021.02.972
Biological Psychiatry, 91, 1, pp. 102-117
Biological Psychiatry
Biological Psychiatry, 91, 102-117
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & iPSYCH 2021, ' Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2021.02.972
Biol Psychiatry
Biological psychiatry 91(1), 102-117 (2022). doi:10.1016/j.biopsych.2021.02.972
Biological Psychiatry. Elsevier USA
Biological Psychiatry, 91(1), 102-117. Elsevier Inc.
Biological psychiatry. Elsevier USA
Blokland, G A M, Grove, J, Chen, C, Cotsapas, C, Tobet, S, Sullivan, P F, Boomsma, D I, Penninx, B W J H, Hottenga, J-J, de Geus, E J C, Willemsen, G, Milaneschi, Y, Als, T D, Børglum, A D, Petryshen, T L, Smoller, J W, Goldstein, J M, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH 2022, ' Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders ', Biological Psychiatry, vol. 91, no. 1, pp. 102-117 . https://doi.org/10.1016/j.biopsych.2021.02.972
Biological Psychiatry, 91(1), 102-117. Elsevier USA
Blokland, G A M, Grove, J, Chen, C Y, Cotsapas, C, Tobet, S, Handa, R, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH 2022, ' Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders ', Biological Psychiatry, vol. 91, no. 1, pp. 102-117 . https://doi.org/10.1016/j.biopsych.2021.02.972
Biological Psychiatry, 91, 1, pp. 102-117
Biological Psychiatry
Biological Psychiatry, 91, 102-117
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & iPSYCH 2021, ' Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2021.02.972
Biol Psychiatry
Biological psychiatry 91(1), 102-117 (2022). doi:10.1016/j.biopsych.2021.02.972
Biological Psychiatry. Elsevier USA
Biological Psychiatry, 91(1), 102-117. Elsevier Inc.
Biological psychiatry. Elsevier USA
Blokland, G A M, Grove, J, Chen, C, Cotsapas, C, Tobet, S, Sullivan, P F, Boomsma, D I, Penninx, B W J H, Hottenga, J-J, de Geus, E J C, Willemsen, G, Milaneschi, Y, Als, T D, Børglum, A D, Petryshen, T L, Smoller, J W, Goldstein, J M, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium & iPSYCH 2022, ' Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders ', Biological Psychiatry, vol. 91, no. 1, pp. 102-117 . https://doi.org/10.1016/j.biopsych.2021.02.972
Contains fulltext : 248656.pdf (Publisher’s version ) (Closed access) BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f533f1ee51f80e7e36bf1609dfb7ae
https://cris.maastrichtuniversity.nl/en/publications/9ef4e1d0-ea1a-49c3-b815-9c883eae4707
https://cris.maastrichtuniversity.nl/en/publications/9ef4e1d0-ea1a-49c3-b815-9c883eae4707
Autor:
António Macedo, Patrick F. Sullivan, Pamela Sklar, Diana O. Perkins, David L. Braff, Eric D. Achtyes, Roman Kotov, Eli A. Stahl, Maria Helena Pinto de Azevedo, Colm O'Dushlaine, Elizabeth Bevilacqua, Célia Barreto Carvalho, Marquis P. Vawter, James Nemesh, Edward M. Scolnick, Jacquelyn L. Meyers, Jorge Valderrama, Shaun Purcell, Becky Kinkead, Douglas S. Lehrer, Peter F. Buckley, William Byerley, Humberto Nicolini, Fabio Macciardi, James L. Kennedy, Michael Escamilla, Ruben C. Gur, Dolores Malaspina, Ashley Dumont, Giulio Genovese, Helena Medeiros, Penelope Georgakopoulos, Colony Abbott, Diane Gage, Carlos N. Pato, Brooke M. Sklar, Roseann E. Peterson, Jordan W. Smoller, Steven A. McCarroll, Raquel E. Gur, Ayman H. Fanous, Laura J. Fochtmann, Stephen R. Marder, Sinéad B. Chapman, Mark Hyman Rapaport, James A. Knowles, Michele T. Pato, Janet L. Sobell, Evelyn J. Bromet, Conrad Iyegbe, Lynn E DeLisi, Jeffrey J. Rakofsky, Oleg V. Evgrafov, Jennifer L. Moran, Christopher P. Morley, Tim B. Bigdeli, Richard A. Belliveau, Mantosh J. Dewan
Publikováno v:
Molecular Psychiatry
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is
Autor:
Martin I. Jones, Joseph D. Szustakowski, Giorgio Sirugo, Lukas Habegger, Adam J. Mansfield, Will Salerno, Joshua D. Backman, Athanasios Kousathanas, David J. Carey, Yi-Pin Lai, James F. Wilson, Alison M. Meynert, Anne E. Justice, Alexander H. Li, Jack A. Kosmicki, Anthony Marcketta, Sándor Szalma, Shane McCarthy, A. R. Shuldiner, A. Baras, Daniel J. Rader, Michael N. Cantor, Ashish Yadav, Manuel A. R. Ferreira, F. S. P. Kury, Konrad Rawlik, Loukas Moutsianas, Gonçalo R. Abecasis, Susan P. Walker, Xing Chen, Albert Tenesa, Paul Nioi, Adam E. Locke, Guillaume Butler-Laporte, E. N. Smith, Richard H Scott, Gundula Povysil, Joseph B. Leader, Lauren Gurski, Dorota Pasko, Marylyn D. Ritchie, A. Cordova-Palomera, Kyoko Watanabe, Colm O'Dushlaine, A. O'Neill, Tomoko Nakanishi, Erola Pairo-Castineira, Xiuwen Zheng, Emily Wong, Jeffrey G. Reid, Slavé Petrovski, Julie E. Horowitz, Anurag Verma, Justin W. Davis, Dylan Sun, Sahar Esmaeeli, Heiko Runz, Quanli Wang, John D. Overton, Shareef Khalid, Tooraj Mirshahi, Evan Maxwell, Mark J. Caulfield, Mark Lathrop, Olympe Chazara, Deepika Sharma, David Goldstein, Jonathan Marchini, Xiaodong Bai, Suganthi Balasubramanian, Krzysztof Kiryluk, Nilanjana Banerjee, Rouel Lanche, J. B. Richards, Hyun Min Kang, J. K. Baillie, Yunfeng Huang, Sean O'Keeffe, Erika Kvikstad, Margaret M. Parker, Joelle Mbatchou
Publikováno v:
American Journal of Human Genetics
2021, ' Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2021.05.017
2021, ' Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2021.05.017
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic v
Autor:
Cassie Stallings, Kevin Sweeney, Lorraine Jones-Brando, Giulio Genovese, Andrea Origoni, Emily Katsafanas, Faith Dickerson, Colm O'Dushlaine, Sunil Khushalani, Robert H. Yolken, Glen Ford
Publikováno v:
Schizophrenia Bulletin
BackgroundEpstein–Barr virus (EBV) is a highly prevalent human herpesvirus capable of infecting the central nervous system and establishing persistent infection.MethodsWe employed solid phase immunoassay techniques to measure immunoglobulin G (IgG)
Autor:
Teresa Tusié-Luna, Svati H. Shah, Wen-Jane Lee, Amit Khera, Gonçalo R. Abecasis, Olle Melander, Alan R. Shuldiner, Connor A. Emdin, Kari Stefansson, Jesper Gromada, Andrew P. Morris, Lee-Ming Chuang, Omri Gottesman, Lars G. Fritsche, Pradeep Natarajan, Marju Orho-Melander, Daniel F. Gudbjartsson, Anubha Mahajan, Marylyn D. Ritchie, William E. Kraus, Tooraj Mirshahi, Colm O'Dushlaine, Jason Flannick, Nicholas J. Wareham, Anne Tybjærg-Hansen, Anders Berg Wulff, Rashmi B. Prasad, Aris Baras, Jonas B. Nielsen, Valgerdur Steinthorsdottir, Yii-Der Ida Chen, Jerome I. Rotter, Lukas Habegger, Samantha N. Fetterolf, David Altshuler, Om Prakash Dwivedi, Tanya M. Teslovich, Cristen J. Willer, Luca A. Lotta, Andrew J. Murphy, Joseph B. Leader, Cristopher V. Van Hout, Christopher D. Still, Ola Hansson, David Birtwell, Alexander Lopez, Daniel J. Rader, John D. Overton, Anthony Marcketta, Patrick Sulem, Peter N. Benotti, Jose C. Florez, Lydia Coulter Kwee, David J. Carey, Oddgeir L. Holmen, Kristian Hveem, Leif Groop, Sekar Kathiresan, Viktoria Gusarova, Unnur Thorsteinsdottir, Cassandra M. Hartle, Uyenlinh L. Mirshahi, H. Lester Kirchner, Shannon Bruse, Robert A. Scott, Michael F. Murray, Marketa Sjögren, Jeffrey G. Reid, Aeron Small, Børge G. Nordestgaard, Amr H. Wardeh, Chad M. Brummett, Mark I. McCarthy, Frederick E. Dewey, David H. Ledbetter, John Penn, Ingrid B. Borecki, Scott M. Damrauer, Hilma Holm, Michael Boehnke, George D. Yancopoulos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and d
Autor:
Shane McCarthy, David H. Ledbetter, Frederick E. Dewey, Lukas Habegger, John Penn, David J. Carey, George D. Yancoupolos, Cristopher V. Van Hout, H. Lester Kirchner, Suganthi Balasubramanian, Joseph B. Leader, Tanya M. Teslovich, Xiaodong Bai, Colm O'Dushlaine, Aris Baras, John D. Overton, Michael F. Murray, Nehal Gosalia, Jeffrey G. Reid, Evan Maxwell, Alan R. Shuldiner, Alexander Lopez, Claudia Gonzaga-Jauregui, Christopher Snyder, Jeffrey Staples, Ricardo Ulloa, Alicia Hawes
Publikováno v:
The American Journal of Human Genetics. 102:874-889
Large-scale human genetics studies are ascertaining increasing proportions of populations as they continue growing in both number and scale. As a result, the amount of cryptic relatedness within these study cohorts is growing rapidly and has signific
Autor:
Lambertus Klei, Jennie G. Pouget, Bernie Devlin, Robert H. Yolken, Vishwajit L. Nimgaonkar, Joel Wood, Faith Dickerson, Kodavali V. Chowdari, Colm O'Dushlaine
Publikováno v:
Psychiatry Research. 261:148-153
Several studies have indicated infectious and immune-related abnormalities in schizophrenia (Scz), including elevated serum C-reactive protein (CRP) - a well-known proxy for infections/immune abnormalities. A portion of the genetic risk for Scz can b
Autor:
Patricia T. Michie, Franziska Degenhardt, Brandon Wormley, Paola Giusti-Rodríguez, Mark J. Daly, Raquelle I. Mesholam-Gately, Ingrid Melle, Sibylle G. Schwab, Andrew McQuillin, Benjamin M. Neale, Joshua L. Roffman, Abraham Reichenberg, Pamela Sklar, Diana O. Perkins, Jennifer L. Moran, Donald W. Black, Per Hoffmann, A. Hofman, Hailiang Huang, John L. Waddington, Giulio Genovese, Aaron R. Wolen, Deborah L. Levy, David Curtis, Digby Quested, Carlos N. Pato, Nicholas John Craddock, Stephanie Williams, Kung Yee Liang, Zhouzhi Wang, Tracey L. Petryshen, Ann E. Pulver, Randy L. Buckner, Stephan Ripke, Roel A. Ophoff, Danielle Posthuma, Lili Milani, Jacques Mallet, Menachem Fromer, Christian R. Marshall, Jaana Suvisaari, Jana Strohmaier, Richard Bruggeman, Marcella Rietschel, Ayman H. Fanous, Andrew M. McIntosh, James T.R. Walters, Dimitris Dikeos, Panos Roussos, Veikko Salomaa, Aiden Corvin, Carin J. Meijer, Tiina Paunio, Assen Jablensky, Sarah E. Bergen, Nancy G. Buccola, Annelie Nordin, Wolfgang Maier, Srdjan Djurovic, Naomi R. Wray, Aniket Shetty, Joel Eriksson, Dan Rujescu, Jouko Lönnqvist, Brian Kelly, Wenting Wu, Alexander Richards, Frans Henskens, Rich Belliveau, Bryan J. Mowry, Elodie Drapeau, Andreas J. Forstner, Silviu Alin Bacanu, Jubao Duan, Tõnu Esko, Bernard Lerer, Carmel M. Loughland, Olli Pietiläinen, Michael Conlon O'Donovan, Shaun M. Purcell, Michael Gill, Thomas G. Schulze, Douglas S. Greer, Stephen W. Scherer, Eli A. Stahl, Markus M. Nöthen, Guiqing Cai, William M. Brandler, Kristin K. Nicodemus, Dominique Campion, David A. Collier, Farooq Amin, Joel N. Hirschhorn, Robin M. Murray, Timothy G. Dinan, Mark Reimers, Murray J. Cairns, Rodney J. Scott, Aarno Palotie, Robert Freedman, Nelson B. Freimer, Joshua R. Atkins, Gary Donohoe, Ann Olincy, Jonathan Sebat, Colm McDonald, Srinivas Thirumalai, John Powell, Jo Knight, Vahram Haroutunian, Dieter B. Wildenauer, Tim B. Bigdeli, Lieuwe de Haan, Peter Eichhammer, James J. Crowley, Lynn E. DeLisi, Ulrich Schall, Rolf Adolfsson, Marcelo Bertalan, Thomas Hansen, Eric Strengman, Michael Davidson, Dheeraj Malhotra, Manuel Mattheisen, Jeffrey A. Lieberman, Benedicto Crespo-Facorro, Stephanie Godard, Edward M. Scolnick, Jonathan Pimm, Bertram Müller-Myhsok, Qingqin Li, Michele T. Pato, Wiepke Cahn, Christos Pantelis, Ingrid Agartz, Brendan Bulik-Sullivan, Madhusudan Gujral, Martilias S. Farrell, Brady J. Maher, Laurent Essioux, Karin V Fuentes Fajarado, Andres Metspalu, Stephanie H. Witt, Patrick F. Sullivan, Mark Weiser, Younes Mokrab, Kai How Farh, Line Olsen, Dermot Walsh, Peter Holmans, Hugh Gurling, Joseph I. Friedman, Andrew Pocklington, Daniel P. Howrigan, Lude Franke, Tune H. Pers, Larry J. Seidman, Pablo V. Gejman, Dalila Pinto, Michael John Owen, Inez Myin-Germeys, Steven A. McCarroll, Wei Cheng, Jackie Goldstein, C. Robert Cloninger, Elliot S. Gershon, Deborah A. Nertney, Thomas Werge, Noa Carrera, Kieran C. Murphy, Rita M. Cantor, Ariel Darvasi, Mark Hansen, Annette M. Hartmann, Ole A. Andreassen, Bradley T. Webb, Henrik B. Rasmussen, David Cohen, Elvira Bramon, Erik G. Jönsson, Vaughan J. Carr, Pui Y. Lee, Masashi Ikeda, Daniele Merico, Danny Antaki, Brien P. Riley, Stefan Herms, Igor Nenadic, Bettina Konte, Kimberley D. Chambert, Jurgen Del Favero, George Kirov, Matthew C. Keller, Jacob Gratten, Douglas F. Levinson, Luba Kalaydjieva, Bhooma Thiruvahindrapuram, Alan R. Sanders, Sang-Yun Oh, Alkes L. Price, Vihra Milanova, Juha Veijola, Erik Söderman, Dragan M. Svrakic, David H. Kavanagh, Patrik K. E. Magnusson, Douglas Blackwood, Nakao Iwata, Jim van Os, Jeremy M. Silverman, Elena Parkhomenko, Kenneth L. Davis, Jing Qin Wu, Eadbhard O'Callaghan, Chris C. A. Spencer, Juha Karjalainen, Anna K. Kähler, Clement C. Zai, Nigel Williams, Joseph D. Buxbaum, Jin P. Szatkiewicz, Laura Nisenbaum, Sang Hong Lee, Yunjung Kim, Colm O'Dushlaine, René S. Kahn, Morten Mattingsdal, Inge Joa, Marian L. Hamshere, Frank Dudbridge, Ina Giegling, Sandra Meier, Derek W. Morris, Robert W. McCarley, Douglas M. Ruderfer, Paul Cormican, Lyudmila Georgieva, Sven Cichon, Josef Frank, Jianxin Shi, George N. Papadimitriou, Kenneth S. Kendler, Margot Albus, Enrico Domenici, Claudine Laurent, Francis A. O'Neill, Adam Savitz, Jordan W. Smoller, James L. Kennedy, Peter M. Visscher, Valentina Escott-Price, Christina M. Hultman, T. Scott Stroup, Elizabeth Bevilacqua, James A. Knowles, William Byerley, Paul A. Tooney, Madeline Alexander, Stanley V. Catts, David St Clair, Sophie E. Legge, Gerald Nestadt, Michelle S. Maile
Publikováno v:
Nature Genetics, 49(1), 27-35. Nature Publishing Group
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Marshall, Christian R; Howrigan, Daniel P; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S; et al.(2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.. Nature genetics, 49(1), 27-35. doi: 10.1038/ng.3725. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/7jq1c9p6
Nature genetics, 49(1), 27-35. Nature Publishing Group
Marshall, C R, Howrigan, D P, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, D S, Antaki, D, Shetty, A, Holmans, P A, Pinto, D, Gujral, M, Brandler, W M, Malhotra, D, Wang, Z, Fajarado, K V F, Maile, M S, Ripke, S, Agartz, I, Albus, M, Alexander, M, Amin, F, Atkins, J, Bacanu, S A, Belliveau, R A, Bergen, S E, Bertalan, M, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Bulik-Sullivan, B, Byerley, W, Cahn, W, Cai, G, Cairns, M J, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Cheng, W, Cloninger, C R, Cohen, D, Cormican, P, Craddock, N, Crespo-Facorro, B, Posthuma, D & Psychosis Endophenotypes International Consortium 2017, ' Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects ', Nature Genetics, vol. 49, no. 1, pp. 27-35 . https://doi.org/10.1038/ng.3725
Marshall, C R, Howrigan, D P, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, D S, Antaki, D, Shetty, A, Holmans, P A, Pinto, D, Gujral, M, Brandler, W M, Malhotra, D, Wang, Z, Fuentes Fajarado, K V, Maile, M S, Ripke, S, Agartz, I, Albus, M, Alexander, M, Amin, F, Atkins, J, Bacanu, S A, Belliveau, R A, Bergen, S E, Bertalan, M, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Bulik-Sullivan, B, Byerley, W, Cahn, W, Cai, G, Cairns, M J, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Cheng, W, Cloninger, C R, Cohen, D, Cormican, P, Craddock, N, Crespo-Facorro, B, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Degenhardt, F, Del Favero, J, DeLisi, L E, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farh, K H, Farrell, M S, Frank, J, Franke, L, Freedman, R, Freimer, N B, Friedman, J I, Forstner, A J, Fromer, M, Genovese, G, Georgieva, L, Gershon, E S, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, J I, Gratten, J, De Haan, L, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Herms, S, Hirschhorn, J N, Hoffmann, P, Hofman, A, Huang, H, Ikeda, M, Joa, I, Kähler, A K, Kahn, R S, Kalaydjieva, L, Karjalainen, J, Kavanagh, D, Keller, M C, Kelly, B J, Kennedy, J L, Kim, Y, Knowles, J A, Konte, B, Laurent, C, Lee, P, Lee, S H, Legge, S E, Lerer, B, Levy, D L, Liang, K Y, Lieberman, J, Lönnqvist, J, Loughland, C M, Magnusson, P K E, Maher, B S, Maier, W, Mallet, J, Mattheisen, M, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S, Meijer, C J, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Müller-Myhsok, B, Murphy, K C, Murray, R M, Myin-Germeys, I, Nenadic, I, Nertney, D A, Nestadt, G, Nicodemus, K K, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, Oh, S Y, Olincy, A, Olsen, L, O'Neill, F A, Van Os, J, Pantelis, C, Papadimitriou, G N, Parkhomenko, E, Pato, M T, Paunio, T, Perkins, D O, Pers, T H, Pietiläinen, O, Pimm, J, Pocklington, A J, Powell, J, Price, A, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Ruderfer, D M, Salomaa, V, Sanders, A R, Savitz, A, Schall, U, Schulze, T G, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Silverman, J M, Smoller, J W, Söderman, E, Spencer, C C A, Stahl, E A, Strengman, E, Strohmaier, J, Stroup, T S, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Thirumalai, S, Tooney, P A, Veijola, J, Visscher, P M, Waddington, J, Walsh, D, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Williams, S, Witt, S H, Wolen, A R, Wormley, B K, Wray, N R, Wu, J Q, Zai, C C, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Cichon, S, Collier, D A, Corvin, A, Daly, M J, Darvasi, A, Domenici, E, Esko, T, Gejman, P V, Gill, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jönsson, E G, Kendler, K S, Kirov, G, Knight, J, Levinson, D F, Li, Q S, McCarroll, S A, McQuillin, A, Moran, J L, Mowry, B J, Nöthen, M M, Ophoff, R A, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Rietschel, M, Riley, B P, Rujescu, D, Sklar, P, St Clair, D, Walters, J T R, Werge, T, Sullivan, P F, O'Donovan, M C, Scherer, S W, Neale, B M & Sebat, J 2017, ' Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects ', Nature Genetics, vol. 49, no. 1, pp. 27-35 . https://doi.org/10.1038/ng.3725
NATURE GENETICS
Nature genetics
Marshall, C R, Howrigan, D P, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, D S, Antaki, D, Shetty, A, Holmans, P A, Pinto, D, Gujral, M, Brandler, W M, Malhotra, D, Wang, Z, Fajarado, K V F, Maile, M S, Ripke, S, Agartz, I, Albus, M, Alexander, M, Amin, F, Atkins, J, Bacanu, S-A, Belliveau, R A, Bergen, S E, Bertalan, M, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Bulik-Sullivan, B K, Byerley, W F, Cahn, W, Cai, G, Cairns, M J, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Cheng, W-T, Cloninger, C R, Cohen, D J, Cormican, P, McIntosh, A & Nicodemus, K & Blackwood, D H R 2017, ' Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects ', Nature Genetics, vol. 49, no. 1, pp. 27-35 . https://doi.org/10.1038/ng.3725
Nature Genetics
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Marshall, Christian R; Howrigan, Daniel P; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S; et al.(2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.. Nature genetics, 49(1), 27-35. doi: 10.1038/ng.3725. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/7jq1c9p6
Nature genetics, 49(1), 27-35. Nature Publishing Group
Marshall, C R, Howrigan, D P, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, D S, Antaki, D, Shetty, A, Holmans, P A, Pinto, D, Gujral, M, Brandler, W M, Malhotra, D, Wang, Z, Fajarado, K V F, Maile, M S, Ripke, S, Agartz, I, Albus, M, Alexander, M, Amin, F, Atkins, J, Bacanu, S A, Belliveau, R A, Bergen, S E, Bertalan, M, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Bulik-Sullivan, B, Byerley, W, Cahn, W, Cai, G, Cairns, M J, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Cheng, W, Cloninger, C R, Cohen, D, Cormican, P, Craddock, N, Crespo-Facorro, B, Posthuma, D & Psychosis Endophenotypes International Consortium 2017, ' Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects ', Nature Genetics, vol. 49, no. 1, pp. 27-35 . https://doi.org/10.1038/ng.3725
Marshall, C R, Howrigan, D P, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, D S, Antaki, D, Shetty, A, Holmans, P A, Pinto, D, Gujral, M, Brandler, W M, Malhotra, D, Wang, Z, Fuentes Fajarado, K V, Maile, M S, Ripke, S, Agartz, I, Albus, M, Alexander, M, Amin, F, Atkins, J, Bacanu, S A, Belliveau, R A, Bergen, S E, Bertalan, M, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Bulik-Sullivan, B, Byerley, W, Cahn, W, Cai, G, Cairns, M J, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Cheng, W, Cloninger, C R, Cohen, D, Cormican, P, Craddock, N, Crespo-Facorro, B, Crowley, J J, Curtis, D, Davidson, M, Davis, K L, Degenhardt, F, Del Favero, J, DeLisi, L E, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, A H, Farh, K H, Farrell, M S, Frank, J, Franke, L, Freedman, R, Freimer, N B, Friedman, J I, Forstner, A J, Fromer, M, Genovese, G, Georgieva, L, Gershon, E S, Giegling, I, Giusti-Rodríguez, P, Godard, S, Goldstein, J I, Gratten, J, De Haan, L, Hamshere, M L, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, A M, Henskens, F A, Herms, S, Hirschhorn, J N, Hoffmann, P, Hofman, A, Huang, H, Ikeda, M, Joa, I, Kähler, A K, Kahn, R S, Kalaydjieva, L, Karjalainen, J, Kavanagh, D, Keller, M C, Kelly, B J, Kennedy, J L, Kim, Y, Knowles, J A, Konte, B, Laurent, C, Lee, P, Lee, S H, Legge, S E, Lerer, B, Levy, D L, Liang, K Y, Lieberman, J, Lönnqvist, J, Loughland, C M, Magnusson, P K E, Maher, B S, Maier, W, Mallet, J, Mattheisen, M, Mattingsdal, M, McCarley, R W, McDonald, C, McIntosh, A M, Meier, S, Meijer, C J, Melle, I, Mesholam-Gately, R I, Metspalu, A, Michie, P T, Milani, L, Milanova, V, Mokrab, Y, Morris, D W, Müller-Myhsok, B, Murphy, K C, Murray, R M, Myin-Germeys, I, Nenadic, I, Nertney, D A, Nestadt, G, Nicodemus, K K, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, Oh, S Y, Olincy, A, Olsen, L, O'Neill, F A, Van Os, J, Pantelis, C, Papadimitriou, G N, Parkhomenko, E, Pato, M T, Paunio, T, Perkins, D O, Pers, T H, Pietiläinen, O, Pimm, J, Pocklington, A J, Powell, J, Price, A, Pulver, A E, Purcell, S M, Quested, D, Rasmussen, H B, Reichenberg, A, Reimers, M A, Richards, A L, Roffman, J L, Roussos, P, Ruderfer, D M, Salomaa, V, Sanders, A R, Savitz, A, Schall, U, Schulze, T G, Schwab, S G, Scolnick, E M, Scott, R J, Seidman, L J, Shi, J, Silverman, J M, Smoller, J W, Söderman, E, Spencer, C C A, Stahl, E A, Strengman, E, Strohmaier, J, Stroup, T S, Suvisaari, J, Svrakic, D M, Szatkiewicz, J P, Thirumalai, S, Tooney, P A, Veijola, J, Visscher, P M, Waddington, J, Walsh, D, Webb, B T, Weiser, M, Wildenauer, D B, Williams, N M, Williams, S, Witt, S H, Wolen, A R, Wormley, B K, Wray, N R, Wu, J Q, Zai, C C, Adolfsson, R, Andreassen, O A, Blackwood, D H R, Bramon, E, Buxbaum, J D, Cichon, S, Collier, D A, Corvin, A, Daly, M J, Darvasi, A, Domenici, E, Esko, T, Gejman, P V, Gill, M, Gurling, H, Hultman, C M, Iwata, N, Jablensky, A V, Jönsson, E G, Kendler, K S, Kirov, G, Knight, J, Levinson, D F, Li, Q S, McCarroll, S A, McQuillin, A, Moran, J L, Mowry, B J, Nöthen, M M, Ophoff, R A, Owen, M J, Palotie, A, Pato, C N, Petryshen, T L, Posthuma, D, Rietschel, M, Riley, B P, Rujescu, D, Sklar, P, St Clair, D, Walters, J T R, Werge, T, Sullivan, P F, O'Donovan, M C, Scherer, S W, Neale, B M & Sebat, J 2017, ' Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects ', Nature Genetics, vol. 49, no. 1, pp. 27-35 . https://doi.org/10.1038/ng.3725
NATURE GENETICS
Nature genetics
Marshall, C R, Howrigan, D P, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, D S, Antaki, D, Shetty, A, Holmans, P A, Pinto, D, Gujral, M, Brandler, W M, Malhotra, D, Wang, Z, Fajarado, K V F, Maile, M S, Ripke, S, Agartz, I, Albus, M, Alexander, M, Amin, F, Atkins, J, Bacanu, S-A, Belliveau, R A, Bergen, S E, Bertalan, M, Bevilacqua, E, Bigdeli, T B, Black, D W, Bruggeman, R, Buccola, N G, Buckner, R L, Bulik-Sullivan, B K, Byerley, W F, Cahn, W, Cai, G, Cairns, M J, Campion, D, Cantor, R M, Carr, V J, Carrera, N, Catts, S V, Chambert, K D, Cheng, W-T, Cloninger, C R, Cohen, D J, Cormican, P, McIntosh, A & Nicodemus, K & Blackwood, D H R 2017, ' Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects ', Nature Genetics, vol. 49, no. 1, pp. 27-35 . https://doi.org/10.1038/ng.3725
Nature Genetics
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obsta
Autor:
Shane McCarthy, Jonathan C. Cohen, Frederick E. Dewey, Claudia Schurmann, Matthew D. Still, Panayiotis Stevis, Xin Chu, Daniel J. Rader, David J. Carey, Alan R. Shuldiner, Noura S. Abul-Husn, Semanti Mukherjee, Jonathan S. Packer, Xiping Cheng, Ann Stepanchick, Brian Zambrowicz, Helen H. Hobbs, John Penn, Uyenlinh L. Mirshahi, Scott M. Damrauer, Ingrid B. Borecki, Yurong Xin, G. Craig Wood, Jesper Gromada, Suganthi Balasubramanian, Tanya M. Teslovich, Andrew J. Murphy, Erin D. Fuller, Christopher D. Still, Tooraj Mirshahi, Jonathan Z. Luo, John D. Overton, George D. Yancopoulos, Yashu Liu, Alexander H. Li, Aeron Small, Omri Gottesman, Julia Kozlitina, Jeffrey G. Reid, Stefan Stender, David Esopi, William C. Olson, Michael Feldman, Colm O'Dushlaine, Alexander E. Lopez, Nehal Gosalia, Sun Y. Kim, Aris Baras
Publikováno v:
The New England journal of medicine. 378(12)
BACKGROUND: Elucidation of the genetic factors underlying chronic liver disease may reveal new therapeutic targets. METHODS: We used exome sequence data and electronic health records from 46,544 participants in the DiscovEHR human genetics study to i