Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christine Reilly"'
Autor:
John E. Leonard, Terrence L. Fisher, Anthony W. Tolcher, Lisa Blaydorn, Jasgit C. Sachdev, Maurice Zauderer, Amita Patnaik, Robert B. Parker, Ramesh K. Ramanathan, Danielle Mutz, Christine Reilly, Glen J. Weiss, Drew W. Rasco, Laurie A. Winter
Publikováno v:
Clinical Cancer Research. 22:827-836
Purpose: Study objectives included evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of VX15/2503 in advanced solid tumor patients. Experimental Design: Weekly i.v. doses were administered on a
Autor:
Ernest S. Smith, Christine Reilly, Sebold Torno, Maurice Zauderer, Mark Paris, Maria Scrivens, Alan S. Jonason, Michael A. Doherty, Tracy Pandina, Holm Bussler, Ekaterina Klimatcheva, Crystal Mallow
Publikováno v:
BMC Immunology
Background Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic cells (FDC) and macrophages. It is the only known ligand for the CXCR5 receptor, w
Autor:
Christine Reilly, John E. Leonard, Maurice Zauderer, Laurie A. Winter, Ernest S. Smith, Chad A. Cornelius, Terrence L. Fisher
Publikováno v:
Molecular cancer therapeutics. 14(4)
The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity to purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine, rat, cynomolgus macaque, and human sequences. The affinity for native SEMA4D expressed on
Autor:
Mark Paris, Alan S. Jonason, Jennifer Seils, Holm Bussler, Maria Scrivens, Christine Reilly, Susan Giralico, Elizabeth E. Evans, Laurie A. Winter, Renee Kirk, Michael A. Doherty, Sebold Torno, Katya Klimatcheva, Ernest S. Smith, Maurice Zauderer, Terrence L. Fisher, Crystal Mallow, William J. Bowers, Alan Howell, Janaki Veeraraghavan
Publikováno v:
Cancer immunology research. 3(6)
Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to correlate with invasive disease in several human tumors. SEMA4D normally functions to regulate
Autor:
Sebold Torno, Jennifer Seils, Crystal Mallow, Chad A. Cornelius, Elizabeth E. Evans, Janaki Veeraraghavan, Ernest S. Smith, Mark Paris, Gareth R. John, Alan S. Jonason, Ekaterina Klimatcheva, Michael A. Doherty, Trinh Pham, John E. Leonard, Maurice Zauderer, William J. Bowers, Terrence L. Fisher, Renee Kirk, Alan Howell, Damir Janigro, Azeb Tadesse Argaw, Christine Reilly, Holm Bussler, Nicola Marchi
Publikováno v:
Neurobiology of Disease, Vol 73, Iss, Pp 254-268 (2015)
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration. There exists a significant ne