Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cara Haymaker"'
Autor:
Salah-Eddine Bentebibel, Willem W. Overwijk, Montaser Shaheen, Marc Uemura, Courtney W. Hudgens, Marihella James, Ravi Murthy, Gary C. Doolittle, Robert H.I. Andtbacka, Chantale Bernatchez, Michael A. Davies, S. Chunduru, Douglas B. Johnson, Daniel H. Johnson, Igor Puzanov, Patrick Hwu, Shah Rahimian, Cara Haymaker, Adi Diab, Joseph Markowitz, Denái R. Milton, Michael T. Tetzlaff, Sudhir Agrawal, Nashat Gabrail, Houssein Safa
Publikováno v:
Cancer Discov
Many patients with advanced melanoma are resistant to immune checkpoint inhibition. In the ILLUMINATE-204 phase I/II trial, we assessed intratumoral tilsotolimod, an investigational Toll-like receptor 9 agonist, with systemic ipilimumab in patients w
Autor:
Cheuk Hong Leung, Wayne L. Hofstetter, John V. Heymach, Alexandre Reuben, Myrna C.B. Godoy, Ara A. Vaporciyan, Padmanee Sharma, Yasir Elamin, Neda Kalhor, Robert R. Jenq, Junya Fujimoto, Tina Cascone, Anne S. Tsao, William N. William, Charles Lu, Frank E. Mott, Nadim J. Ajami, Don L. Gibbons, Jack A. Roth, David C. Rice, Luisa M. Solis, Hai T. Tran, Brett W. Carter, Lauren Averett Byers, Andrew Futreal, Lorenzo Federico, Annikka Weissferdt, Garrett L. Walsh, Reza J. Mehran, Chantale Bernatchez, George R. Blumenschein, Jennifer A. Wargo, Heather Lin, Cara Haymaker, Xiuning Le, Jonathan M. Kurie, Mehmet Altan, James P. Allison, Stephen G. Swisher, Edwin R. Parra, Boris Sepesi, Hitoshi Dejima, Frank V. Fossella, Jianjun Zhang, Bonnie S. Glisson, Mara B. Antonoff, Abdul Wadud Khan, Apar Pataer, Alejandro Francisco-Cruz, Ignacio I. Wistuba, Humam Kadara, J. Jack Lee, Ferdinandos Skoulidis
Publikováno v:
Nat Med
Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report the results of the phase 2 ran
Autor:
Cara Haymaker, Jason Roszik, Jie Qing Chen, Jahan Khalili, Zhe Wang, Nikunj Satani, Rina M. Mbofung, Laurence J.N. Cooper, Marie-Andree Forget, Willem W. Overwijk, Chunyu Xu, Leila Williams, Weiyi Peng, Chengwen Liu, Deborah A. Silverman, Simone Punt, Sourindra Maiti, Florian L. Muller, Elien M Doorduijn, Chantale Bernatchez, Trang N. Tieu, Ana Lucia Dominguez, Soraya Zorro Manrique, Patrick Hwu, Shruti Malu, Emily Ashkin, Jodi A. McKenzie, Rodabe N. Amaria, Timothy P. Heffernan
Publikováno v:
Cancer Immunology, Immunotherapy
Although immunotherapy has achieved impressive durable clinical responses, many cancers respond only temporarily or not at all to immunotherapy. To find novel, targetable mechanisms of resistance to immunotherapy, patient-derived melanoma cell lines
Autor:
Joseph Celestino, Cara Haymaker, Chantale Bernatchez, Marie Andrée Forget, Patrick Hwu, Donastas Sakellariou-Thompson, Emily Hinchcliff, Amir A. Jazaeri
Publikováno v:
Cancer Immunol Immunother
BACKGROUND: Immunotherapy has become a powerful treatment option for several solid tumor types. The presence of tumor-infiltrating lymphocytes (TIL) is correlated with better prognosis in ovarian cancer, pointing at the possibility to benefit from ha
Autor:
Funda Meric-Bernstam, Cara Haymaker, Caitlin Creasy, Marie Andrée Forget, Coya Tapia, Sharjeel H. Sabir, Aung Naing, Gopal Singh, Bettzy Stephen, Chantale Bernatchez, Mingxuan Xu
Publikováno v:
European Journal of Immunology. 49:2245-2251
The pervasive use of therapeutic antibodies targeting programmed cell death protein 1 (PD-1) to boost anti-tumor immunity has positioned this approach to become the standard-of-care for some solid tumor malignancies. However, little is known as to ho
Autor:
Ignacio I. Wistuba, M. Casarrubios, Gerardo Huidobro, Edel del Barco, A. Insa, Carlos Tarin, Fernando Franco, Alberto Cruz-Bermúdez, Cara Haymaker, Ernest Nadal, Mariano Provencio, Raquel Laza-Briviesca, Aránzazu García-Grande, Manuel Domine, Manuel Cobo, Margarita Majem, M.-R. García-Campelo, Atocha Romero, Reyes Bernabe Caro, Guillermo López Vivanco, Nuria Viñolas, Santiago Viteri, Delvys Rodriguez-Abreu, Bartomeu Massuti, Isidoro Barneto Aranda, Belén Sierra-Rodero, Alex Martinez-Marti, Javier de Castro Carpeño
Publikováno v:
Clinical and Translational Medicine
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Background Immunotherapy is being tested in early‐stage non‐small cell lung cancer (NSCLC), and achieving higher rates of complete pathological responses (CPR) as compared to standard of care. Early identification of CPR patients has vital clinic
Autor:
Laszlo Radvanyi, Cara Haymaker, Sapna Pradyuman Patel, Adi Diab, Elizabeth J. Shpall, Roland L. Bassett, Rodabe N. Amaria, Chantal Saberian, Patrick Hwu, Hussein Abdul-Hassan Tawbi, Sapna R. Parshottam, Marie Andrée Forget, Amer Najjar, Jennifer L. McQuade, Michael A. Davies, Gregory Lizée, Chantale Bernatchez, Victor G. Prieto, Cassian Yee, Silvana de Castro Faria, Isabella C. Glitza, Michael K. Wong, Enrique Alvarez
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
BackgroundThe adoptive transfer of tumor-infiltrating lymphocytes (TIL) has demonstrated robust efficacy in metastatic melanoma patients. Tumor antigen–loaded dendritic cells (DCs) are believed to optimally activate antigen-specific T lymphocytes.
Autor:
Jack A. Roth, David C. Rice, Garrett L. Walsh, Ara A. Vaporciyan, Ravi Rajaram, Rodabe N. Amaria, Cara Haymaker, Erin M. Corsini, Mara B. Antonoff, Reza J. Mehran, Stephen G. Swisher, Wayne L. Hofstetter, Amir A. Jazaeri, Nicolas Zhou, Boris Sepesi, Chantale Bernatchez, Marie-Andree Forget, Kyle G. Mitchell
Publikováno v:
Journal of surgical oncologyREFERENCES. 124(4)
Background and objectives Adoptive T-cell therapies (ACTs) using expansion of tumor-infiltrating lymphocyte (TIL) populations are of great interest for advanced malignancies, with promising response rates in trial settings. However, postoperative out
Autor:
Young Uk Kim, Marie Andrée Forget, Rahmatu Mansaray, Rene J. Tavera, Arely Wahl, Patrick Hwu, Seth Wardell, Esteban Flores, Dan S. Gombos, Audrey M. Gonzalez, Laszlo Radvanyi, Orenthial J. Fulbright, Christopher Toth, Donastas Sakellariou-Thompson, Rodabe N. Amaria, Renjith Ramachandran, Caitlin Creasy, Cara Haymaker, Sapna Pradyuman Patel, Ankit Bhatta, Chantale Bernatchez, Shawne T. Thorsen
Publikováno v:
Journal of Immunotherapy. 41:399-405
In this study, we address one of the major critiques for tumor-infiltrating lymphocyte (TIL) therapy-the time needed for proper expansion of a suitable product. We postulated that T-cell receptor activation in the first phase of expansion combined wi
Autor:
Ravi Rajaram, Reza J. Mehran, Ara A. Vaporciyan, Boris Sepesi, Mara B. Antonoff, Nicolas Zhou, Anne S. Tsao, Stephen G. Swisher, Wayne L. Hofstetter, Jack A. Roth, Erin M. Corsini, David C. Rice, Percy Lee, Garrett L. Walsh, Cara Haymaker
Publikováno v:
The Annals of thoracic surgery. 113(1)
Background Whether extrapleural pneumonectomy (EPP) or extended pleurectomy/decortication (P/D) is the optimal resection for malignant pleural mesothelioma remains controversial. We therefore compared perioperative outcomes and long-term survival of