Zobrazeno 11 - 20
of 23
pro vyhledávání: '"Cara Haymaker"'
Autor:
Jianhua Zhang, P. Andrew Futreal, Curtis Gumbs, David C. Rice, Ignacio I. Wistuba, Alexandre Reuben, Runzhe Chen, Stephen G. Swisher, Boris Sepesi, Chi-Wan Chow, J. Jack Lee, Xin Hu, Won-Chul Lee, Hai T. Tran, John V. Heymach, Jianjun Zhang, Anne S. Tsao, Reza J. Mehran, Junya Fujimoto, Latasha Little, Cara Haymaker, Jun Li
Publikováno v:
Clin Cancer Res
Purpose:Malignant pleural mesothelioma (MPM) is considered an orphan disease with few treatment options. Despite multimodality therapy, the majority of MPMs recur and eventually become refractory to any systemic treatment. One potential mechanism und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3a99699a7b2f6c3b1ff29bea7ff0d6
https://europepmc.org/articles/PMC7709879/
https://europepmc.org/articles/PMC7709879/
Autor:
Chantale Bernatchez, Jing Wang, Alexandre Reuben, Hitoshi Dejima, Alejandro Francisco-Cruz, Tina Cascone, Ignacio I. Wistuba, Lorenzo Federico, Don L. Gibbons, Tatiana Karpinets, Boris Sepesi, Stephen G. Swisher, Edwin R. Parra, Marcelo V. Negrao, Jianjun Zhang, Mara B. Antonoff, Kyle G. Mitchell, John V. Heymach, Hai T. Tran, Lixia Diao, Erin M. Corsini, Ara A. Vaporciyan, Cara Haymaker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundThe biological underpinnings of the prognostic and predictive significance of a relative neutrophilia in patients with non-small lung cancer (NSCLC) are undefined. We sought to comprehensively examine the relationships between circulating a
Autor:
Cheuk Hong Leung, Humam Kadara, Ara A. Vaporciyan, Padmanee Sharma, William N. William, Stephen G. Swisher, Annikka Weissferdt, Abdul Wadud Khan, Ignacio I. Wistuba, J. Jack Lee, Nadim J. Ajami, James P. Allison, Jennifer A. Wargo, Luisa M. Solis, John V. Heymach, Yushu Shi, Tina Cascone, Robert R. Jenq, Kyle G. Mitchell, Myrna C.B. Godoy, Edwin R. Parra, Shalini S. Yadav, Don L. Gibbons, Apar Pataer, Sreyashi Basu, Heather Lin, Boris Sepesi, Cara Haymaker
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Radiographic imaging is the standard approach for evaluating the disease involvement of lymph nodes in patients with operable NSCLC although the impact of neoadjuvant immune checkpoint inhibitors (ICIs) on lymph nodes has not yet been characterized.
Autor:
Marie Andrée Forget, Barbara Pazdrak, Yared Hailemichael, Meenu Sharma, Patrick Hwu, Cara Haymaker, Adi Diab, Binisha Karki, Ute Hoch, Christina Vianden, Deborah H. Charych, Manisha Singh, Caitlin Creasy, Cristian Coarfa, Michael E. Hurwitz, Salah Eddine Bentebibel, Mario Sznol, Uddalak Bharadwaj, Hiep Khong, Kimal Rajapakshe, Chantale Bernatchez, David J. Tweardy, Jonathan Zalevsky, Murali Addepalli, Srinivas Vennam, Faisal Fa’ak, Willem W. Overwijk, Shixia Huang, Louise M.E. Janssen, Brent C. Chesson, Laura Maria S. Kahn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
High dose interleukin-2 (IL-2) is active against metastatic melanoma and renal cell carcinoma, but treatment-associated toxicity and expansion of suppressive regulatory T cells (Tregs) limit its use in patients with cancer. Bempegaldesleukin (NKTR-21
Autor:
Daniel C. Cho, Harriet M. Kluger, Scott N. Gettinger, Chantale Bernatchez, Christie Fanton, Yijie Liao, Ernesto Iacucci, Mary Tagliaferri, Michael E. Hurwitz, Alison L. Hannah, Scott S. Tykodi, Cara Haymaker, Salah Eddine Bentebibel, Adi Diab, Ute Hoch, Jonathan Zalevsky, Vassiliki A. Papadimitrakopoulou, Sandra Aung, Mario Sznol, Ahsan Naqi Rizwan, Patrick Hwu, Nizar M. Tannir, Brendan D. Curti
Publikováno v:
Cancer discovery. 10(8)
This single-arm, phase I dose-escalation trial (NCT02983045) evaluated bempegaldesleukin (NKTR-214/BEMPEG), a CD122-preferential IL2 pathway agonist, plus nivolumab in 38 patients with selected immunotherapy-naïve advanced solid tumors (melanoma, re
Autor:
Marie-Andree Forget, Min Zhang, Rina M. Mbofung, Ashish Kalra, Timothy P. Heffernan, R. Eric Davis, Trang N. Tieu, Weiyi Peng, Florian L. Muller, Seram Devi, Cara Haymaker, Patrick Hwu, Chantale Bernatchez, Chengwen Liu, Soraya Zorro Manrique, Anil K. Sood, Chunyu Xu, Leila Williams, Nikunj Satani, Jodi A. McKenzie, Shruti Malu, Rodabe N. Amaria, Sunila Pradeep, Yuan Chen, Emily Ashkin, Lu Huang, Jason Roszik, Jianhua Hu
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Immunotherapy has increasingly become a staple in cancer treatment. However, substantial limitations in the durability of response highlight the need for more rational therapeutic combinations. The aim of this study is to investigate how t
Autor:
Michael T. Tetzlaff, Wen-Jen Hwu, Ann Phillip, Irina Fernandez, Cara Haymaker, Adi Diab, Chantale Bernatchez, Paul D. Brown, Caitlin Creasy, Luis M Vence, Natalie McQuail, Courtney W. Hudgens, James P. Allison, Padmanee Sharma, Marc Uemura, Patrick Hwu, Dae Won Kim
Publikováno v:
Cancer Immunology Research. 5:100-105
We report here on a patient with metastatic melanoma who had extensive brain metastases. After being treated with the sequential combination of whole brain radiation therapy followed by the PD-1–inhibitory antibody, pembrolizumab, the patient had a
Autor:
J. Zhang, L.M. Solis Soto, Barbara Mino, J. Jack Lee, Alexandre Reuben, I. I. Wistuba, Don L. Gibbons, James G. Fujimoto, A. Vaporcyan, Frederick F. Lang, Jason T. Huse, Dzifa Y. Duose, Humam Kadara, Hitoshi Dejima, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri, Edwin R. Parra, Norihiko Ikeda, Y. Kudo, Cesar A. Moran, Cara Haymaker, Ronald Abraham
Publikováno v:
Ann Oncol
BACKGROUND: The tumor immune microenvironment (TIME) of lung cancer brain metastasis is largely unexplored. We carried out immune profiling and sequencing analysis of paired resected primary tumors and brain metastases of non-small-cell lung carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c4d924bad8ac65a413e4793ad73903
https://europepmc.org/articles/PMC6771224/
https://europepmc.org/articles/PMC6771224/
Autor:
J. Jack Lee, William N. William, Erminia Massarelli, Faye M. Johnson, Young Uk Kim, Michael A. Curran, Cornelis J. M. Melief, Bonnie S. Glisson, Jing Wang, Ignacio I. Wistuba, Merrill S. Kies, Hai T. Tran, Chantale Bernatchez, Cara Haymaker, Renata Ferrarotto, Tomas Zecchini Barrese, Ming Guo, Lerong Li, Jaime Rodriguez Canales, Lei Feng, Sjoerd H. van der Burg
Publikováno v:
JAMA Oncology, 5(1), 67-73
Importance In recurrent human papilloma virus (HPV)–driven cancer, immune checkpoint blockade with anti–programmed cell death 1 (PD-1) antibodies produces tumor regression in only a minority of patients. Therapeutic HPV vaccines have produced str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297df8eed8b27f7e590b8d1dc57eb8ca
https://hdl.handle.net/1887/119499
https://hdl.handle.net/1887/119499
Autor:
Carlos A. Torres-Cabala, Jeffrey E. Gershenwald, Jason Roszik, Vruti Patel, Wen-Jen Hwu, Anthony Lucci, M. I. Ross, Arely Wahl, Orenthial J. Fulbright, Yuzhong Jeff Meng, Christopher Toth, Tatiana Karpinets, Cara Haymaker, Chantell M. Farinas, Sapna Pradyuman Patel, Adi Diab, Caitlin Creasy, Patrick Hwu, Renjith Ramachandran, Jeffrey E. Lee, Isabella C. Glitza, Ankit Bhatta, Destiny Joy Carpio, Rodabe N. Amaria, Esteban Flores, Suzanne Cain, Michael K. Wong, Laszlo Radvanyi, Rameen Beroukhim, Portia G. Velasquez, Hussein Abdul-Hassan Tawbi, Chantale Bernatchez, Carol Vaughn, Shawne T. Thorsen, Marie Andrée Forget, Michael A. Davies, Young Uk Kim, Seth Wardell, Janice N. Cormier, Scott E. Woodman, Jennifer A. Wargo, Rahmatu Mansaray, Richard E. Royal, Rene J. Tavera, Audrey M. Gonzalez, Kenneth R. Hess, Donastas Sakellariou-Thompson
Purpose: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent widespread use of checkpoint blockade has shifted the treatment landscape, raising question
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd2241bcc6c3505a54b6f6cfb5977d7
https://europepmc.org/articles/PMC6139043/
https://europepmc.org/articles/PMC6139043/