Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Autor:
Jennifer R. Pyle, V. Craig Jordan, Andres J. Klein-Szanto, Helen Kim, Joan S. Lewis-Wambi, Chris Wambi, Roshani R. Patel
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-3 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired
Autor:
Manti Guha, Prasanna M. Chandramouleeswaran, Andres J. Klein-Szanto, James Garifallou, Clementina Mesaros, Hiroshi Nakagawa, Renata Pellegrino da Silva, Ian A. Blair, Noah Engel, Eishi Noguchi, Joseph A. Baur, Masataka Shimonosono, Hakon Hakonarson, Uma M. Sachdeva, Gordon Ruthel, Michael Gonzalez, Shinya Ohashi, Hisatsugu Maekawa, Kelly A. Whelan, Sarmistha Mukherjee
Publikováno v:
BASE-Bielefeld Academic Search Engine
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While
Autor:
Andrea Ventura, Riccardo Fodde, Antonio Percesepe, Alfonso Bellacosa, David P. Turner, Valentina Rovella, Maurizio Ponz de Leon, Karthik Devarajan, Juul T. Wijnen, Maurizio Genuardi, Pietro Mancuso, Salvatore Cortellino, Andres J. Klein-Szanto, Emanuela Lucci-Cordisco, Antonio Riccio, Rossella Tricarico, Heleen M. van der Klift, Pål Møller, Alessandra Viel, Kathy Q. Cai, Monica Pedroni, Paolo Radice, Lucio Bertario, Shantie Jagmohan-Changur, Giovanni Neri
Publikováno v:
Oncotarget
Oncotarget, 6(40), 42892-42904. Impact Journals LLC
Oncotarget, 6(40), 42892-42904. Impact Journals LLC
The DNA glycosylase gene MBD4 safeguards genomic stability at CpG sites and is frequently mutated at coding poly-A tracks in mismatch repair (MMR)-defective colorectal tumors (CRC). Mbd4 biallelic inactivation in mice provided conflicting results as
Autor:
Dong-Hua Yang, Andrey Gorin, Elizabeth Handorf, Diana Restifo, Gail E. Herman, Erica A. Golemis, Igor Astsaturov, Kunal Manocha, Linara Gabitova, Andres J. Klein-Szanto, Lisa E. Kratz, Kathy Q. Cai, David Cunningham
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1927-1938 (2015)
SummaryMeiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor receptor (EGFR) or RAS increases the demand
Autor:
Xiang Xi Xu, Andrew K. Godwin, Andres J. Klein-Szanto, Ying Wang, Toni M. Yeasky, Elizabeth R. Smith, Thomas C. Hamilton, Robert B. Moore, Parvin Ganjei-Azar, Kathy Q. Cai
Publikováno v:
Molecular and cellular biology. 36(18)
We modeled the etiology of postmenopausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, incorporating oncogenic mutations. Ovarian cancer incidence is highest in peri- and postmenopausal women, and epidemi
Autor:
Daniel E. Bassi, Tianyu Li, Emmanuelle Nicolas, Jirong Zhang, Andres J. Klein-Szanto, Jian Fu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 4, Pp 271-282 (2012)
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression. In vitro studies using cancer cell lines and clini
Autor:
Lionel Larue, Florian Rambow, Marisa S. Bartolomei, Tiziana Bruno, Dominique Kobi, Salvatore Cortellino, Christophe Alberti, Alfonso Bellacosa, Irwin Davidson, Jinfei Xu, Yoshihiro Matsumoto, Antonio Cigliano, Mara Sannai, Maurizio Fanciulli, Lara K. Abramowitz, Andy Wessels, Dianne Robert Soprano, Karthik Devarajan, Andres J. Klein-Szanto, Elena Caretti, Madeleine Le Coz, Catherine Renner, Robert Moore, Maria Rosaria Bassi
Publikováno v:
Cell. 146:67-79
SummaryDNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an a
Autor:
Heiner Westphal, Zhe-Sheng Chen, Alex Grinberg, Timothy Churchill, Emmanuelle Nicolas, Chelsy Paulose, Andres J. Klein-Szanto, Elizabeth Hopper-Borge, Yehong Kuang, Gary D. Kruh, Martin G. Belinsky, Joely D. Jacobs, Olivia Ngo
Publikováno v:
Cancer Research. 71:3649-3657
Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer resistance to a variety of anticancer agents, including taxanes. However, the in vivo functions of the
Autor:
Marcelo G. Kazanietz, Jiansong Luo, Mark A. Lemmon, HongBin Wang, John M. Busillo, Maria Soledad Sosa, Cynthia Lopez-Haber, J. Silvio Gutkind, Ramon Parsons, Andres J. Klein-Szanto, Jeffrey L. Benovic, Chengfeng Yang, Hiroshi Yagi
Publikováno v:
Molecular Cell. 40:877-892
While the small GTPase Rac1 and its effectors are well-established mediators of mitogenic and motile signaling by tyrosine kinase receptors and have been implicated in breast tumorigenesis, little is known regarding the exchange factors (Rac-GEFs) th