Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alexei A. Grom"'
Autor:
Grant S. Schulert, Mekibib Altaye, Jackeline Rodriguez-Smith, Alyssa Sproles, Virginia Miraldi Utz, Sheila T. Angeles-Han, Sherry Thornton, Alexei A. Grom, Adam Kauffman, Najima Mwase, Theresa Hennard, Gary N. Holland
Publikováno v:
Ocul Immunol Inflamm
PURPOSE: Biomarkers for juvenile idiopathic arthritis-associated uveitis (JIA-U) are needed. We aimed to measure inflammatory biomarkers in tears as a non-invasive method to identify biomarkers of uveitis activity. METHODS: Tears were collected from
Autor:
Jipan Xie, Nina Kim, Kathleen G Lomax, Peter Hur, Raju Gautam, Jordan Cammarota, Raluca Ionescu-Ittu, Navneet Sanghera, Ameur M. Manceur, Alexei A. Grom
Publikováno v:
Pediatric Rheumatology Online Journal
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-13 (2021)
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-13 (2021)
Background Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well understood. We aimed to chara
Autor:
Jie Zheng, Athimalaipet V Ramanan, Shan Luo, Tom R. Gaunt, Shiu Lun Au Yeung, Sarah L. N. Clarke, C. Mary Schooling, Carl D. Langefeld, Susan D. Thompson, Alexei A. Grom, Miranda C. Marion
Publikováno v:
Luo, S, Clarke, SLN, Ramanan, AV, Thompson, SD, Langefeld, CD, Marion, MC, Grom, AA, Schooling, CM, Gaunt, TR, Yeung, SLA & Zheng, J 2021, ' Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis : A Mendelian Randomization Study ', Arthritis and Rheumatology, vol. 73, no. 4, pp. 693-701 . https://doi.org/10.1002/art.41561
Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & Rheumatology (Hoboken, N.j.)
ObjectiveTo ascertain the role of platelet glycoprotein Ib α‐chain (GPIbα) plasma protein levels in cardiovascular, autoimmune, and autoinflammatory diseases and whether its effects are mediated by platelet count.MethodsWe performed a two‐sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cb43beccd693aa867d01ed1ad5dc43
https://hdl.handle.net/1983/90e74b2d-07e3-4216-8fc8-896ec197fd34
https://hdl.handle.net/1983/90e74b2d-07e3-4216-8fc8-896ec197fd34
Autor:
Ndate Fall, Rachel A. Brown, Cem Gabay, Scott W. Canna, Grant S. Schulert, Shima Yasin, Alexei A. Grom, Maggie Henderlight, Charlotte Girard-Guyonvarc'h
Publikováno v:
Rheumatology (Oxford)
Rheumatology, Vol. 59, No 2 (2020) pp. 361-366
Rheumatology, Vol. 59, No 2 (2020) pp. 361-366
Objectives Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-
Autor:
Sherry Thornton, Kathryn A. Wikenheiser-Brokamp, Michael B. Jordan, Kairavee Thakkar, Maggie Henderlight, Grant S. Schulert, Christopher W. Woods, Alexei A. Grom, Nathan Salomonis, Denny K Gao
Publikováno v:
JCI Insight
Macrophage activation syndrome (MAS) is a life-threatening cytokine storm complicating systemic juvenile idiopathic arthritis (SJIA) driven by IFN-γ. SJIA and MAS are also associated with an unexplained emerging inflammatory lung disease (SJIA-LD),
Autor:
Gulnara Nasrullayeva, Daniela Gerent Petry Piotto, Vafa Mammadova, Zuoming Deng, Vibke Lilleby, Annet van Royen-Kerkhof, Andreas Reiff, Troy R. Torgerson, Sara Taber, Mary Beth F. Son, Laura S. Finn, Anne Marie C. Brescia, Yangfeng Hou, Philip J. Hashkes, Marco Gattorno, Alexei A. Grom, Elizabeth Stringer, Marite Rygg, Lisa G. Rider, Eric P. Hanson, Eric J. Allenspach, Ruy Carrasco, Elizabeth A. Kessler, Susan Moir, Ian Ferguson, Edward M. Behrens, Bita Arabshahi, Heinrike Schmeling, Victoria R. Dimitriades, Theresa Wampler Muskardin, Polly J. Ferguson, Rolando Cimaz, Pascal Pillet, Adriana Almeida de Jesus, Maria Teresa Terreri, Andrew J. Oler, Pui Y. Lee, Liliana Bezrodnik, Laura B Lewandowski, Rita Jerath, Stephen R. Brooks, Bernadette Marrero, Tova Ronis, Hanna Kim, Amina Ahmed, Alice Y. Chan, Yuriy Stepanovskiy, Christiaan Scott, Angelique Biancotto, Nancy Pan, Ronald M. Laxer, Adam L Reinhardt, Yan Huang, Johannes Roth, Paul Dancey, Suzanne C. Li, Lakshmi N. Moorthy, Jason Dare, Gisella Seminario, Raphaela Goldbach-Mansky, Natasha M. Ruth, Gina A. Montealegre Sanchez, Grant S. Schulert, Gerd Horneff, Min Ae Lee-Kirsch, Seza Ozen, Daniel J. Kingsbury, Louise Malle, Susanne M. Benseler, Rafael Rivas-Chacon, Laura L. Tosi, Scott W. Canna, Ronit Herzog, Angela Rösen-Wolff, Katherine R. Calvo, Sharon Bout-Tabaku, Diane E. Brown, Jon M. Burnham, Andrew I. Shulman, Karen Onel, Cynthia J. Tifft, Christian M. Hedrich, Vidya Sivaraman, Marilynn Punaro, Kathleen M. O'Neil, Marietta DeGuzman, María Soledad Caldirola
Publikováno v:
The Journal of clinical investigation, vol 130, iss 4
J Clin Invest
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J Clin Invest
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments. METHODS. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548766e234ab1c57c7cf4e03193e4e2c
https://escholarship.org/uc/item/49d2m8ws
https://escholarship.org/uc/item/49d2m8ws
Autor:
Ndate Fall, Grant S. Schulert, Thuy Do, Sherry Thornton, Alex V. Pickering, Alexei A. Grom, Daniel Schnell, Mario Medvedovic, Nathan Salomonis, Sanjeev Dhakal
Publikováno v:
Annals of the rheumatic diseases. 80(5)
ObjectivesSystemic juvenile idiopathic arthritis (SJIA) confers high risk for macrophage activation syndrome (MAS), a life-threatening cytokine storm driven by interferon (IFN)-γ. SJIA monocytes display IFN-γ hyper-responsiveness, but the molecular
Autor:
Joshua E. Elias, Claudia Macaubas, Peggie Cheung, Peter A. Nigrovic, Alexei A. Grom, Paul J. Utz, Or Gozani, Tie-Mei Li, Purvesh Khatri, Lauren A. Henderson, Michele Donato, Elizabeth D. Mellins, John P. Coan, Grant S. Schulert, Lichao Zhang, Sarah E. Chang, Steven Schaffert, Mai Dvorak, Mariko Hinton Foecke, Alex J. Kuo
Publikováno v:
Nature immunology. 22(6)
Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage development. This abundant histone mark i
Autor:
Jon L. Woltmann, Robert W. Frenck, Grant S. Schulert, Andrew H. Shapiro, Alexei A. Grom, Onengiya Harry, Judith A. Smith
Publikováno v:
JCR: Journal of Clinical Rheumatology. 24:287-290
Autor:
Ndate Fall, Hermine I. Brunner, Jessica L Turnier, Simone Appenzeller, Sherry Thornton, Marisa S. Klein-Gitelman, David P. Witte, Michael R. Bennett, Alexei A. Grom
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potential bioma