Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yasuo Urata"'
Autor:
Masahiko Nishizaki, Shinji Kuroda, Takeshi Nagasaka, Yuuri Hashimoto, Yasuo Urata, Yasuhiro Shirakawa, Satoru Kikuchi, Hiroshi Tazawa, Robert M. Hoffman, Shunsuke Kagawa, Hiroyuki Kishimoto, Toshiyoshi Fujiwara
Publikováno v:
Molecular Therapy. 23(3):501-509
Currently, early gastrointestinal cancers are treated endoscopically, as long as there are no lymph node metastases. However, once a gastrointestinal cancer invades the submucosal layer, the lymph node metastatic rate rises to higher than 10%. Theref
Autor:
Satoru Kyo, Masahiko Nishizaki, Shunsuke Kagawa, Toshiyoshi Fujiwara, Noriaki Tanaka, Fuminori Teraishi, Katsuyuki Nagai, Masaki Taki, Takeshi Kawashima, Yasuo Urata, Tatsuo Umeoka
Publikováno v:
Cancer Research. 64(17):6259-6265
Currently available methods for detection of tumors in vivo such as X-ray, computed tomography, and ultrasonography are noninvasive and have been well studied; the images, however, are not specific for tumors. Direct optical imaging of tumor cells in
Autor:
Toshiyoshi Fujiwara, Hiromi Kumon, Takashi Saika, Yasuo Urata, Masami Watanabe, Peng Huang, Jie Chen, Yuji Kashiwakura, Yasutomo Nasu, Haruki Kaku
Publikováno v:
Cancer gene therapy. 17(7)
OBP-301 (a telomerase-specific, replication-competent adenovirus with hTERT promoter) was constructed in a previous study and it showed a strong anticancer effect by inducing cell lysis in human lung and prostate cancer cells. This study investigated
Autor:
James M. Burke, Beena O. Pappen, Salina Chen, Daiju Ichimaru, Neil Senzer, Ned Adams, Anagha P. Phadke, Yasuo Urata, Alex W. Tong, Cynthia Bedell, John Nemunaitis, Yu An Zhang, Toshiyoshi Fujiwara, Phillip B. Maples, Michael Nemunaitis
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 18(2)
A phase I clinical trial was conducted to determine the clinical safety of Telomelysin, a human telomerase reverse transcriptase (hTERT) promoter driven modified oncolytic adenovirus, in patients with advanced solid tumors. A single intratumoral inje
Autor:
Noriko Mori, Yasuo Urata, Tomomi Ikoma, Masaki Inoue, Satoru Kyo, Manabu Hashimoto, Masahiro Takakura, Yasunari Mizumoto, Nakamura Masahito, Toshiyoshi Fujiwara
Publikováno v:
Cancer Gene Therapy
Despite tremendous development in chemotherapy for ovarian cancer over the past few decades, the prognosis of advanced cases with massive peritoneal dissemination is still unsatisfactory, and novel treatment modalities that can combine with chemother
Autor:
Satoru Kyo, Manabu Hashimoto, Junko Sakaguchi, Yasuo Urata, Masahiro Takakura, Masaki Inoue, Toshiyoshi Fujiwara, Tomomi Ikoma, Mitsuhiro Nakamura, Noriko Mori, Yoshiko Maida, Yasunari Mizumoto
Publikováno v:
International journal of oncology. 34(6)
Cytological cancer screening that targets genetic or epigenetic abnormalities may be a viable alternative to morphological screening. Detecting cancer cells by specific genetic markers helps their easy detection in cytological samples. We recently es
Autor:
Futoshi Uno, Yoshikatsu Endo, Hiroyuki Kishimoto, Yuuri Hashimoto, Shunsuke Kagawa, Yasuo Urata, Shinji Kuroda, Ryo Sakai, Toshiyoshi Fujiwara, Noriaki Tanaka, Yoshihiro Ikeda, Yuichi Watanabe, Masayoshi Hioki, Toru Kojima
Publikováno v:
Scopus-Elsevier
Soluble factors in the tumor microenvironment may influence the process of angiogenesis; a process essential for the growth and progression of malignant tumors. In this study, we describe a novel antiangiogenic effect of conditional replication-selec
Autor:
Noriaki Tanaka, Takao Hayakawa, Satoru Kyo, Katsuyuki Nagai, Masahiko Nishizaki, Shunsuke Kagawa, Hiroyuki Mizuguchi, Masaki Taki, Toshiyoshi Fujiwara, Yasuo Urata
Publikováno v:
Oncogene. 24(19)
Replication-competent oncolytic viruses are being developed for human cancer therapy. We previously reported that an attenuated adenovirus (OBP-301, 'Telomelysin'), in which the hTERT promoter element drives expression of E1A and E1B genes linked wit