Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jiri Bartek"'
Autor:
Natalie Kudlova, Hanus Slavik, Pavlina Duskova, Tomas Furst, Josef Srovnal, Jiri Bartek, Martin Mistrik, Marian Hajduch
Publikováno v:
Aging (Albany NY)
In accordance with the 3 Rs principle (to replace, reduce and refine) animal models in biomedical research, we have developed and applied a new approach for sampling and analyzing hair follicles in various experimental settings. This involves use of
Autor:
Rastislav Dzijak, Zdenek Hodny, Jiri Bartek, Alena Moudra, Vojtech Tambor, Miroslav Pribyl, Lukas Rob, Sona Hubackova, Lenka Kyjacova, Jiri Svec, Pavel Vodicka, Barbora Salovska, Hynek Strnad, Radka Vaclavikova, Terezie Imrichova
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 13, Iss 7, Pp 1467-1489 (2019)
Molecular Oncology, Vol 13, Iss 7, Pp 1467-1489 (2019)
Radiation and chemotherapy represent standard‐of‐care cancer treatments. However, most patients eventually experience tumour recurrence, treatment failure and metastatic dissemination with fatal consequences. To elucidate the molecular mechanisms
Autor:
Ke Cong, Jiri Bartek, Graeme C. Smith, Sharon B. Cantor, Jinhyuk Bhin, Marieke van de Ven, Miguel Andújar-Sánchez, Mariana Paes Dias, Vivek Tripathi, Stefano Annunziato, Eleni Maria Manolika, Cor Lieftink, Roderick L. Beijersbergen, Jos Jonkers, Ingrid van der Heijden, Jirina Bartkova, Arnab Ray Chaudhuri, Sanjiban Chakrabarty, Sven Rottenberg, Ewa Gogola, Panagiotis Galanos
Publikováno v:
Mol Cell
Molecular Cell, 81(22), 4692-4708.e9. Cell Press
Molecular Cell, 81(22), 4692-4708.e9. Cell Press
SUMMARYInhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, preclinical and clinical research with PARPi has reveal
Autor:
Jannick Brennum, Jiri Bartek, Diana Aguilar-Morante, Petra Hamerlik, Elisabeth Anne Adanma Obara, Rikke Darling Rasmussen, Lucie Tučková, Alex Frias, Robert Strauss, Henriette Pedersen, Christoffel Dinant, Kirstine Juul Elbæk, Yi Chieh Lim, Kamilla E. Jensen, Kristoffer Vitting-Serup, Jane Skjøth-Rasmussen, Lina Vardouli
Publikováno v:
Obara, E A A, Aguilar-Morante, D, Rasmussen, R D, Frias, A, Vitting-Serup, K, Lim, Y C, Elbæk, K J, Pedersen, H, Vardouli, L, Jensen, K E, Skjoth-Rasmussen, J, Brennum, J, Tuckova, L, Strauss, R, Dinant, C, Bartek, J & Hamerlik, P 2020, ' SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells ', Nature Communications, vol. 11, 4709 . https://doi.org/10.1038/s41467-020-18549-8
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin state and the accessibil
Autor:
Wei-Ting Lu, Lykourgos-Panagiotis Zalmas, Konstantinos Evangelou, Ersilia Nigro, Vitor H. Teixeira, Mary Y. Wu, Robertus A.M. de Bruin, Ayse U. Akarca, Nicholas McGranahan, Michelle Dietzen, Panagiotis Galanos, Adam Pennycuick, Clare Puttick, Eric Santoni-Rugiu, Bryan Ngo, Jiri Bartek, William L. Brown, Sam M. Janes, Haoran Zhai, Deborah R. Caswell, Sebastijan Hobor, Cosetta Bertoli, Emilia L. Lim, Tim R. Fenton, Mariam Jamal-Hanjani, Reuben S. Harris, Roberto Bellelli, Brittany B. Campbell, Mihaela Angelova, Samuel F. Bakhoum, Eva Grönroos, Yue Zhao, Thomas B.K. Watkins, Robert E. Hynds, Vassilis G. Gorgoulis, Apolinar Maya-Mendoza, Maise Al Bakir, Charles Swanton, Teresa Marafioti, Andrew Rowan, Nnennaya Kanu, Michael Howell, Jirina Bartkova, Simon J. Boulton, Subramanian Venkatesan, Haiquan Chen
Publikováno v:
Cancer Discovery
Venkatesan, S, Angelova, M, Puttick, C, Zhai, H, Caswell, D R, Lu, W, Dietzen, M, Galanos, P, Evangelou, K, Bellelli, R, Lim, E L, Watkins, T B K, Rowan, A, Teixeira, V H, Zhao, Y, Chen, H, Ngo, B, Zalmas, L, Al Bakir, M, Hobor, S, Grönroos, E, Pennycuick, A, Nigro, E, Campbell, B B, Brown, W L, Akarca, A U, Marafioti, T, Wu, M Y, Howell, M, Boulton, S J, Bertoli, C, Fenton, T R, De Bruin, R A M, Maya-mendoza, A, Santoni-rugiu, E, Hynds, R E, Gorgoulis, V G, Jamal-hanjani, M, Mcgranahan, N, Harris, R S, Janes, S M, Bartkova, J, Bakhoum, S F, Bartek, J, Kanu, N & Swanton, C 2021, ' Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution ', Cancer Discovery, vol. 11, no. 10, pp. 2456-2473 . https://doi.org/10.1158/2159-8290.CD-20-0725
Cancer Discov
Venkatesan, S, Angelova, M, Puttick, C, Zhai, H, Caswell, D R, Lu, W, Dietzen, M, Galanos, P, Evangelou, K, Bellelli, R, Lim, E L, Watkins, T B K, Rowan, A, Teixeira, V H, Zhao, Y, Chen, H, Ngo, B, Zalmas, L, Al Bakir, M, Hobor, S, Grönroos, E, Pennycuick, A, Nigro, E, Campbell, B B, Brown, W L, Akarca, A U, Marafioti, T, Wu, M Y, Howell, M, Boulton, S J, Bertoli, C, Fenton, T R, De Bruin, R A M, Maya-mendoza, A, Santoni-rugiu, E, Hynds, R E, Gorgoulis, V G, Jamal-hanjani, M, Mcgranahan, N, Harris, R S, Janes, S M, Bartkova, J, Bakhoum, S F, Bartek, J, Kanu, N & Swanton, C 2021, ' Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution ', Cancer Discovery, vol. 11, no. 10, pp. 2456-2473 . https://doi.org/10.1158/2159-8290.CD-20-0725
Cancer Discov
APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when APOBEC3 expression is induced during cancer development remains to be defined. Here we show that specific APOBEC3 genes are upregulated in breast ductal carcinoma in situ, a
Autor:
Maximilian Richter, Sheng Ding, Robert Strauss, Charles W. Drescher, Ruan van Rensburg, André Lieber, Min Xie, Anja Ehrhardt, Jiri Bartek, Kamola Saydaminova
Publikováno v:
Cancer Biology & Therapy. 17:1079-1088
Chemotherapy often fails to eradicate cancer stem cells (CSCs) that drive cancer recurrence. In fact, the treated tumors often contain a higher frequency of chemo-resistant CSCs. It is thought that CSC formation is supported by exposure of cancer cel
Autor:
Ivo Vrobel, Boris Cvek, Petr Dzubak, Martin Mistrik, Tomas Ozdian, Jirina Bartkova, Jiri Bartek, Pavla Pouckova, Jindrich Sedlacek, Jana Vaclavkova, Søren Friis, Marianne Kraus, Zdenek Skrott, Christoph Driessen, Jing Li, Raymond J. Deshaies, Jørgen H. Olsen, Martina Michalova, Pavel Moudry, Klaus Kaae Andersen, Q. Ping Dou, Dusana Majera, Andrea Miklovicova, Marian Hajduch, Jana Mattova, Zsofia Turi, Jan Gursky, Anne Kutt
Publikováno v:
Nature
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repu
Publikováno v:
Electrophoresis. 20:372-381
The members of the 'pocket protein' family, comprising the retinoblastoma tumor suppressor (pRB) and its relatives, p107 and p130, negatively regulate cell proliferation and modulate fundamental biological processes including embryonic development, d
Publikováno v:
The Journal of Pathology. 172:237-245
Recent evidence from genetic studies suggests that abnormalities of some of the members of the cyclin superfamily may be intimately associated with tumourigenesis, most likely through deregulation of the cell cycle control. In an attempt to elucidate
Autor:
Zong-Yi Li, Jiri Bartek, Hui Song, André Lieber, Robert Strauss, Qinghua Feng, Ruan van Rensburg, Pascal Fender, Roma Yumul, Ines Beyer, Jonas Persson, Hongjie Wang
The efficacy of monoclonal antibodies (mAb) used to treat solid tumors is limited by intercellular junctions which tightly link epithelial tumor cells to each another. In this study, we define a small, recombinant adenovirus serotype 3-derived protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b106b218d0b38334c7244c9a61740002
https://europepmc.org/articles/PMC3217128/
https://europepmc.org/articles/PMC3217128/