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pro vyhledávání: ''
Autor:
Ryuhei Okada, Hisataka Kobayashi, Aki Furusawa, Peter L. Choyke, Hiroaki Wakiyama, Takuya Kato, Fuyuki Inagaki, Daiki Fujimura
Publikováno v:
Cancer Science
Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment, which was recently approved in Japan for patients with inoperable head and neck cancer. NIR‐PIT utilizes antibody‐IRDye700DX (IR700) conjugates and NIR light at a w
Autor:
David Llobet-Navas, Jose M. Silva, Partha Mukhopadhyay, Meredith L Davis, Rachel L Werner, Laura Devis-Jauregui, Erin A. Nekritz, Koon-Kiu Yan, Ruth Rodriguez-Barrueco, Jiyang Yu
Publikováno v:
EMBO Rep
During the female lifetime, the expansion of the epithelium dictated by the ovarian cycles is supported by a transient increase in the mammary epithelial stem cell population (MaSCs). Notably, activation of Wnt/β-catenin signaling is an important tr
Autor:
Miha Modic, Jamie S. Mitchell, Jacob Neeves, Jernej Ule, Linda Greensmith, Raphaëlle Luisier, Doaa M Taha, Jia Newcombe, Ione Meyer, Giulia E. Tyzack, Rickie Patani, Nicholas M. Luscombe
Publikováno v:
Brain
See Vidal and Atkin (doi:10.1093/brain/awz256) for a scientific commentary on this article. ALS remains incurable due to an incomplete understanding of its molecular pathogenesis. Tyzack, Luisier et al. report that FUS protein, previously thought to
A comparison of DNA/RNA extraction protocols for high-throughput sequencing of microbial communities
Autor:
Rodolfo A. Salido, Karenina Sanders, Pedro Belda-Ferre, Cameron Martino, Carolina S. Carpenter, Stephen Wandro, Livia S. Zaramela, Sandrine Miller-Montgomery, Justin P. Shaffer, Jeremiah J. Minich, Gregory Humphrey, MacKenzie Bryant, Austin D. Swafford, Serena Fraraccio, Rob Knight, Mehrbod Estaki, Clarisse Marotz, Gail Ackermann
Publikováno v:
bioRxiv
Biotechniques
BioTechniques, vol 70, iss 3
Biotechniques
BioTechniques, vol 70, iss 3
One goal of microbial ecology researchers is to capture the maximum amount of information from all organisms in a sample. The recent COVID-19 pandemic, caused by the RNA virus SARS-CoV-2, has highlighted a gap in traditional DNA-based protocols, incl
Autor:
Paul B. Harvilla, Ninkka Tamot, Adam Zwolak, Jason Ho, Matthew D. Truppo, Rajitha Doddareddy, Tong-Yuan Yang, M. Jack Borrok, Ian White, Chowdhury Partha, Qun Jiao, Rajkumar Ganesan, Brian Geist
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The global health crisis and economic tolls of COVID-19 necessitate a panoply of strategies to treat SARS-CoV-2 infection. To date, few treatment options exist, although neutralizing antibodies against the spike glycoprotein have proven to be effecti
Autor:
Michel C. Nussenzweig, Jennifer R. Keeffe, Christopher O. Barnes, Yu E. Lee, Pauline R. Hoffman, Susan Ou, Hung-Jen Wu, Alexander A. Cohen, Leesa M. Kakutani, Anthony P. West, Pamela J. Bjorkman, Mark Howarth, Priyanthi N. P. Gnanapragasam
Publikováno v:
Science
Science, 371(6530):735-741
Science (New York, N.y.)
bioRxiv
article-version (status) pre
article-version (number) 1
Science, 371(6530):735-741
Science (New York, N.y.)
bioRxiv
article-version (status) pre
article-version (number) 1
Fighting zoonotic coronaviruses In the past 20 years, three betacoronaviruses thought to have originated in bats have caused devastating disease in humans. The global pandemic caused by the latest such virus, severe acute respiratory syndrome coronav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46309a536c6a32339ee8494c4bc7b752
https://doi.org/10.1101/2020.11.17.387092
https://doi.org/10.1101/2020.11.17.387092
Autor:
Maria Gomez, Edmund C. Jenkins, Nagma Shah, Gabriella Casalena, Timothy C. Kenny, Dazhi Zhao, Giovanni Manfredi, Sara R. Guariglia, Doris Germain
Publikováno v:
EMBO Reports
Defects in the proteasome can result in pathological proteinopathies. However, the pathogenic role of sex‐ and tissue‐specific sensitivity to proteotoxic stress remains elusive. Here, we map the proteasome activity across nine tissues, in male an
Autor:
Frédéric Saudou, Julie Bruyère, Lydia Saidi, Yann Ehinger, Chiara Scaramuzzino, Emilie Borloz, Hélène Vitet, Benoît Delatour, Laurent Villard, Yah-Se Abada, Jean-Christophe Roux, Valerie Matagne, Nicolas Panayotis
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2020, 12 (2), ⟨10.15252/emmm.201910889⟩
EMBO Molecular Medicine, Wiley Open Access, 2020, 12 (2), pp.e10889. ⟨10.15252/emmm.201910889⟩
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Web of Science
EMBO Molecular Medicine, 2020, 12 (2), pp.e10889. ⟨10.15252/emmm.201910889⟩
EMBO Molecular Medicine, Wiley Open Access, 2020, 12 (2), ⟨10.15252/emmm.201910889⟩
EMBO Molecular Medicine, Wiley Open Access, 2020, 12 (2), pp.e10889. ⟨10.15252/emmm.201910889⟩
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Web of Science
EMBO Molecular Medicine, 2020, 12 (2), pp.e10889. ⟨10.15252/emmm.201910889⟩
Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain‐derived neurotrophic fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3fb438750db968abd6786b5e3b342b
https://hal.archives-ouvertes.fr/hal-03035540
https://hal.archives-ouvertes.fr/hal-03035540
Autor:
Teemu Smura, Frederic A. Meunier, Minou Djannatian, Jonas Franz, Martin Sebastian Winkler, Christine Stadelmann, Leonora Szirovicza, Brit Mollenhauer, Ari Helenius, Pamela Österlund, Olli Vapalahti, Tuğberk Kaya, Sarah J. Butcher, Maria Anastasina, Lev Levanov, Ravi Ojha, Suvi Kuivanen, Ludovico Cantuti-Castelvetri, Mikael Simons, Hannimari Kallio-Kokko, Ozgun Gokce, Giuseppe Balistreri, Katri Kallio, Merja Joensuu, Liliana D. Pedro, Allan Tobi, Franziska van der Meer, Tambet Teesalu, Jussi Hepojoki
Publikováno v:
Science
Science, 370 (6518)
Science (New York, N.y.)
Science / Science now 370(6518), 856-860 (2020). doi:10.1126/science.abd2985
Signal Transduction and Targeted Therapy
Science, 370 (6518)
Science (New York, N.y.)
Science / Science now 370(6518), 856-860 (2020). doi:10.1126/science.abd2985
Signal Transduction and Targeted Therapy
Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a recept
Autor:
Nam-Hyung Kim, Xiang Shun Cui, Jung-Woo Kwon, Bao Yuan, Hai Yang Wang, In-Won Lee, Tian Yi Sun
Publikováno v:
Cell Cycle. 16:1774-1780
Unlike somatic cells mitosis, germ cell meiosis consists of 2 consecutive rounds of division that segregate homologous chromosomes and sister chromatids, respectively. The meiotic oocyte is characterized by an absence of centrioles and asymmetric div