Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ena Wang"'
Autor:
Willem W. Overwijk, Patrick Hwu, Francesco M. Marincola, Geok Choo Sim, Caitlin Creasy, Laszlo Radvanyi, Chengwen Liu, Elizabeth A. Grimm, Hui Liu, Zhimin Dai, Ena Wang, Jason Roszik
Publikováno v:
Cancer Immunology Research. 4:983-994
Clinical responses to high-dose IL2 therapy are limited due to selective expansion of CD4+CD25+Foxp3+ T-regulatory cells (Treg), especially ICOS+ Tregs, rather than natural killer (NK) cells and effector T cells. These ICOS+ Tregs are highly suppress
Autor:
Valentina Mattei, Ramzi Temanni, Rebecca Mathew, Davide Bedognetti, Lee Silcock, Barbara Seliger, Rashid Al-Ali, Ena Wang, Francesca Lessi, Sara Tomei, Puthen V. Jithesh, Hakeem Almabrazi, Francesco M. Marincola, Muna Al-Hashmi, Nicola James, Younes Mokrab
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-7 (2019)
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-7 (2019)
Background Monoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as the expression of a gene that is restricted to one allele in the presence of a dip
Autor:
Kimberly A. Chianese-Bullock, Anne M. Stowman, Mark E. Smolkin, Nadedja Galeassi, Francesco M. Marincola, Kelly T. Smith, Nolan A. Wages, Lynn T. Dengel, Craig L. Slingluff, Ileana S. Mauldin, Ena Wang, David W. Mullins, Donna H. Deacon, Gina R. Petroni, Walter C. Olson
Publikováno v:
Cancer Immunology, Immunotherapy. 65:1189-1199
Optimal approaches to induce T cell infiltration of tumors are not known. Chemokines CXCL9, CXCL10, and CXCL11 support effector T cell recruitment and may be induced by IFN. This study tests the hypothesis that intratumoral administration of IFNγ wi
Autor:
M K Al-Kowari, Dhanya Kizhakayil, Lotfi Chouchane, A Haoudi, A Ismail Chouchane, Pu Li, George Kulik, Ena Wang, M A Al-Muftah, Konduru S Sastry, Francesco M. Marincola
Publikováno v:
Cell Death & Differentiation. 21:1936-1949
Emerging evidence suggests that the resistance of cancer stem cells (CSC) to many conventional therapies is one of the major limiting factors of cancer therapy efficacy. Identification of mechanisms responsible for survival and self-renewal of CSC wi
Autor:
Walter C. Olson, Craig L. Slingluff, Kelly T. Smith, David W. Mullins, Rachael A. Clark, Nadedja Galeassi, Mark E. Smolkin, Ileana S. Mauldin, Ena Wang, Francesco M. Marincola, Jessica E. Teague, Anne M. Stowman, Nolan A. Wages, Donna H. Deacon, Gina R. Petroni, Kimberly A. Chianese-Bullock
Publikováno v:
Cancer immunology, immunotherapy : CII. 65(10)
Infiltration of cancers by T cells is associated with improved patient survival and response to immune therapies; however, optimal approaches to induce T cell infiltration of tumors are not known. This study was designed to assess whether topical tre
Autor:
Yingdong Zhao, William W. Grosh, Geoffrey R. Weiss, Ena Wang, Craig L. Slingluff, Hui Liu, Kimberly A. Chianese-Bullock, Francesco M. Marincola
Publikováno v:
Clinical Cancer Research. 17:7440-7450
Purpose: We have previously shown that within tumors, recombinant interleukin-2 (rIL-2, aldesleukin) consistently activates tumor-associated macrophages and upregulates IFN-stimulated genes while inducing minimal migration, activation, or proliferati
Autor:
Pilar de la Rocha, Begoña Comin-Anduix, Elizabeth Seja, Arturo Villanueva, Francesco M. Marincola, John A. Glaspy, Jason Jalil, Ena Wang, Alistair J. Cochran, Antoni Ribas, Tara A. McCannel, Jesus Gomez-Navarro, Maria Teresa Ochoa, Bradley R. Straatsma, Denise K. Oseguera, Liu Hui, James S. Economou, Bartosz Chmielowski
Publikováno v:
Clinical Cancer Research. 15:6267-6276
Purpose: Tumor antigen–loaded dendritic cells (DC) are believed to activate antitumor immunity by stimulating T cells, and CTL-associated antigen 4 (CTLA4)–blocking antibodies should release a key negative regulatory pathway on T cells. The combi
Autor:
Monica C. Panelli, Dae Won Kim, Seunghee Kim-Schulze, David F. Stroncek, Marianna Sabatino, Ena Wang, Gail DeRaffele, Zoltan Pos, Francesco M. Marincola, Bret Taback, Howard L. Kaufman
Publikováno v:
Journal of Clinical Oncology. 27:2645-2652
Purpose High-dose interleukin-2 (IL-2) induces durable therapeutic responses in a small subset of patients with metastatic melanoma and renal cell carcinoma, but simple pretreatment predictors of response have not been identified. Patients and Method
Conservation of Genetic Alterations in Recurrent Melanoma Supports the Melanoma Stem Cell Hypothesis
Autor:
Yingdong Zhao, Marianna Sabatino, Alessandro Monaco, Francesco M. Marincola, Michele Maio, Laszlo Karai, Sonia Voiculescu, Ena Wang, Silvia Selleri, Brian J. Nickoloff, Paul D. Robbins
Publikováno v:
Cancer Research. 68:122-131
It is generally accepted that human cancers derive from a mutated single cell. However, the genetic steps characterizing various stages of progression remain unclear. Studying a unique case of metastatic melanoma, we observed that cell lines derived
Autor:
Marcus Bosenberg, Zulmarie Franco, Rahul Roychoudhuri, Liqiang Xi, Gautam U. Mehta, Hui Liu, Nicolas Acquavella, David Clever, Joseph G. Crompton, David F. Stroncek, Douglas C. Palmer, Mark Raffeld, James J. Morrow, Ena Wang, Christopher A. Klebanoff, Luca Gattinoni, Ken-ichi Hanada, Chyi-Chia Richard Lee, Alena Gros, Yun Ji, Zhiya Yu, Holger Pflicke, Melody E. Roelke-Parker, Madhusudhanan Sukumar, Ian S. Goldlust, Francesco M. Marincola, Nicholas P. Restifo
Publikováno v:
Cancer immunology research. 3(1)
Both targeted inhibition of oncogenic driver mutations and immune-based therapies show efficacy in treatment of patients with metastatic cancer, but responses can be either short lived or incompletely effective. Oncogene inhibition can augment the ef