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Autor:
Helen E. Ritchie, Elizabeth Hegedus, Dominqiue Abela, Andrew M. Howe, Emma Farrell, Deena Ababneh
Publikováno v:
Reproductive Toxicology. 106:109-114
Phenytoin is a known human teratogen with unknown etiology. Several mechanisms have been proposed including disturbances in folate metabolism, induction of embryonic hypoxia following phenytoin-induced bradycardia, free radical formation following re
Autor:
Camille S. Westlake, David M. Aronoff
Publikováno v:
Current Drug Safety. 16:299-308
Background: Ivermectin is widely used for the treatment of neglected tropical diseases associated with adverse maternal and fetal outcomes when the infection complicates the pregnancy. However, the United States FDA classification and current distrib
Autor:
Anderson Joel Martino-Andrade, Claudia Rülker, Marcella Tapias Passoni, Bennard van Ravenzwaay, Gabriele Palu, Caroline Gomes, Nicole Grechi, Bruna Andreotti da Silva Amaral
Publikováno v:
Toxicology Letters. 352:1-8
Dipyrone is a commonly used analgesic in many countries and there is limited data on its possible endocrine disrupting effects. We performed a screening for in vivo and in vitro anti(estrogenic) activity of dipyrone. For the in vivo uterotrophic assa
Autor:
Danielle Dias Pinto Ferreira, Ricardo Augusto de Melo Reis, Mariana Nunes Marinho Ritter Ferreira, Pâmella de Moura, Maurício Dos Santos Pereira, Gustavo C. Ferreira, Thais da Rosa Valli, Regina Célia Cussa Kubrusly, Vladimir Pedro Borges-Martins, Robertta Silva Martins, Alex C. Manhães, Matheus F. Sathler
Publikováno v:
Neurotoxicity Research. 39:1946-1958
The spontaneously hypertensive rat (SHR) is an excellent animal model that mimics the behavioral and neurochemical phenotype of attention-deficit/hyperactivity disorder (ADHD). Here, we characterized the striatal GABA transport of SHR and investigate
Publikováno v:
Toxicol Sci
The legalization and increasing availability of cannabis products raises concerns about the impact on offspring of users, and little has appeared on the potential contribution of paternal use. We administered cannabis extract to male rats prior to ma
Autor:
Kristen R. Breit, Irene Shkolnikov, Hannah M.O. Reid, Cristina G. Rodriguez, Taylor M. Snowden, Jennifer D. Thomas, Brian R. Christie
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: We have recently shown that alcohol and cannabis can interact prenatally, and in a recent review paper we further identified Parvalbumin-positive (PV) interneurons in the hippocampus as a potential point of convergence for these teratogen
Autor:
Ali Sharif, Azhar Rasul, Sobia Younas, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim, Mohammad Saleem, Muhammad Furqan Akhtar, Ammara Saleem
Publikováno v:
Birth Defects Research. 113:1407-1421
OBJECTIVES Tramadol, an atypical opioid, is clinically efficacious in treating moderate to severe pain. The aim of current study was to find out the toxicological effects of tramadol exposure to pregnant rats and fetuses during the late phase of preg
Publikováno v:
Reproductive Toxicology. 104:16-26
Experimental models of maternal diabetes lead to the intrauterine programming of Gestational Diabetes Mellitus (GDM) in the offspring, together with an intrauterine proinflammatory environment, feto-placental metabolic alterations and fetal overgrowt
Autor:
Leon F. Stankowski, Sarah Ann Tincher, Isaac V. Cohen, Tyson Paul Dubnicka, Sara Beth Hurtado, Berra Yazar-Klosinski, Laken Barber
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
3,4 Methylenedioxymethamphetamine (MDMA)-assisted therapy has been recently found to be highly effective for treatment of posttraumatic stress disorder (PTSD). Previous studies have been inconclusive in elucidating potential MDMA genotoxicity. We per
Autor:
Suhkmann Kim, Hyang Yeon Kim, Kyu-Bong Kim, Ji-Woon Kim, Yong Jae Lee, Mee Jung Ko, Jung Dae Lee, Chan Young Shin, Sun Jae Kim
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 85:1-13
Prenatal exposure to valproic acid (VPA) has been implicated in the manifestation of autism spectrum disorder (ASD)-like behavioral and functional changes both in human and rodents including mice and rats. The objective of this study was to determine