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Publikováno v:
Journal of Biochemical and Molecular Toxicology. 35
The aim of this study was to evaluate the potential of syringic acid (SA) against propylthiouracil (PTU)-induced hypothyroidism in rats. SA at a prestandardized dose, 50 mg/kg/day, was orally administered to PTU-induced hypothyroid rats for 30 days,
Publikováno v:
Toxicology mechanisms and methods. 31(7)
Radiation-induced pulmonary fibrosis (RIPF) is a known complication in cancer patients after getting thoracic radiotherapy. Aromatase inhibitors (AIs) as anastrozole have been used instead of tamoxifen for adjuvant endocrine treatment of postmenopaus
Publikováno v:
Pharmacology, biochemistry, and behavior. 209
Neuronal adaptations involving dopaminergic, glutamatergic, and serotonergic neurotransmitter systems are responsible for behavioral sensitization. Because of common underlying mechanisms, cross-sensitization between compounds of different drug class
Autor:
Fatima den Ouden, Willem G. Schoonen, Emiel Rorije, Joop de Knecht, Edwin P. Zwart, Hennie M. Hodemaekers, Leo T.M. van der Ven, Renate M. Groot, Harm J. Heusinkveld
The zebrafish embryo toxicity test (ZFET) is a simple medium-throughput test to inform about (sub)acute lethal effects in embryos. Enhanced analysis through morphological and teratological scoring, and through gene expression analysis, detects develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cc6788abb3fe6d8eeabac5f930497a
http://hdl.handle.net/10029/624957
http://hdl.handle.net/10029/624957
Publikováno v:
Toxicology and industrial health. 37(6)
Synthetic amorphous silica (SAS) nanomaterial – consisting of aggregates and agglomerates of primary silicon dioxide (SiO2) particles in the nanorange (
Publikováno v:
Humanexperimental toxicology. 40(10)
Acetaminophen (APAP) is often used as an antipyretic and analgesic agent. Overdose hepatotoxicity, which often results in liver cell failure and liver transplantation, is a severe complication of APAP usage. To save the liver and save lives from acut
Autor:
Sandra Maria Miraglia, Vanessa Vendramini, G.S. Souza, J.C. Souza, Camila Cicconi Paccola, I.M.M. Freitas, L.L. Martins
Publikováno v:
Toxicology and applied pharmacology. 426
Gonadal development begins in the intrauterine phase and females from most species are born with an established oocyte reserve. Exposure to drugs during gestation can compromise the offspring health, also affecting the gametes quality. Nicotine, the
Autor:
Anna Sznejder-Pachołek, Justyna Pyrzanowska, Dagmara Mirowska-Guzel, Ewa Widy-Tyszkiewicz, Ilona Joniec-Maciejak, Agnieszka Piechal, Kamilla Blecharz-Klin, Adriana Wawer
Publikováno v:
Drug and chemical toxicology. 45(4)
In this study, we investigated the effects of early paracetamol treatment on the testicular level of testosterone and expression of genes important for steroid biosynthesis and reproduction in male rats offspring. Rats were continuously exposed to pa
Autor:
Ilina Krasteva, Ilza Pajeva, Petko Alov, Aleksandar Shkondrov, Vessela Vitcheva, Merilin Al Sharif, Georgi Popov, Rumyana Simeonova, Vasil Manov
Publikováno v:
Food and Chemical Toxicology. 130:317-325
Triterpenoids are well known modulators of metabolic syndrome. One of the suggested modes of action (MoAs) involves peroxisome proliferator-activated receptor gamma (PPARγ) binding. In this study we aimed to: (i) evaluate in silico potential metabol
Autor:
Hannah White, Marty Cauley, Zachary Spiera, Leah Yao, Edward D. Levin, Shaqif Junaid, Andrew B. Hawkey
Publikováno v:
Birth Defects Res
Tobacco smoke is a complex mixture that includes thousands of compounds. Previously, we have found that gestational exposure to the complex mixture of tobacco smoke extract caused long-term neurobehavioral impairments. In this study, we examined the