Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Itaru Kojima"'
Autor:
Testsuya Kitaguchi, Itaru Kojima, Kazushige Sakaguchi, Masahiro Nagasawa, Anny Fernandez, Yuko Nakagawa, Johan Medina
Publikováno v:
Journal of Biological Chemistry. 291(No. 44):23126-23135
The calcium-sensing receptor (CaSR) is activated by various cations, cationic compounds, and amino acids. In the present study we investigated the effect of glucose on CaSR in HEK293 cells stably expressing human CaSR (HEK-CaSR cells). When glucose c
Autor:
Itaru Kojima, Yuko Nakagawa, Masahiro Nagasawa, Shigeki Takeda, Yoshiaki Ohtsu, Hirokazu Arakawa
Publikováno v:
Molecular and Cellular Endocrinology. 394:70-79
Sweet taste receptor regulates GLP-1 secretion in enteroendocrine L-cells. We investigated the signaling system activated by this receptor using Hutu-80 cells. We stimulated them with sucralose, saccharin, acesulfame K and glycyrrhizin. These sweeten
Publikováno v:
Endocrine journal. 63(8)
Sucralose is an artificial sweetener and activates the glucose-sensing receptor expressed in pancreatic β-cells. Although sucralose does not enter β-cells nor acts as a substrate for glucokinase, it induces a marked elevation of intracellular ATP (
Publikováno v:
Journal of Cellular Physiology. 210:692-702
The present study was conducted to characterize the regulation and function of TRPV2 in macrophages. Among six members of the TRPV family channels, only the expression of TRPV2 was detected in macrophages. We then determined localization of TRPV2 usi
Autor:
Itaru Kojima, Chikara Sato, Masahiro Sokabe, Keiji Naruse, Masahiro Nagasawa, Hidetoshi Iida, Makoto Kanzaki
Publikováno v:
Science. 285:882-886
Calcium-permeable, stretch-activated nonselective cation (SA Cat) channels mediate cellular responses to mechanical stimuli. However, genes encoding such channels have not been identified in eukaryotes. The yeast MID1 gene product (Mid1) is required
Publikováno v:
Journal of Biological Chemistry. 272:4964-4969
CD20 functions as a calcium-permeable cation channel. When expressed in Balb/c 3T3 cells, CD20 accelerates the G1 progression induced by insulin-like growth factor-I (IGF-I). To further characterize how CD20 modulates the action of IGF-I, we investig
Publikováno v:
Biochemical Journal. 297:523-528
The present study was conducted to monitor precisely the activity of protein kinase C (PKC) in adrenal glomerulosa cells stimulated by angiotensin II (ANG II). PKC activity in cells was monitored by measuring phosphorylation of a synthetic KRTLRR pep
Autor:
Itaru Kojima, Masahiro Nagasawa
Publikováno v:
Cell calcium. 51(2)
The present study was conducted to investigate localization and function of TRPV2 channel in a mouse macrophage cell line, TtT/M87. We infected an adenovirus vector encoding TRPV2 tagged with c-Myc in the extracellular domain. Immunoreactivity of c-M
Autor:
Itaru Kojima, H. Mogami
Publikováno v:
Biochemical and Biophysical Research Communications. 196:650-658
The present study was conducted to determine a role of calcium entry in the growth promoting action of platelet-derived growth factor (PDGF) in cultured rat vascular smooth muscle cells. Addition of PDGF to quiescent cells induced a rapid elevation o
Publikováno v:
FEBS Letters. 329:194-198
Activin A stimulated insulin secretion in rat pancreatic islets, an effect that was attenuated by reduction of extracellular Ca2+ and abolished by either nitrendipine or verapamil. Activin A increased intracellular the free Ca2+ concentration, [Ca2+]