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pro vyhledávání: '"Charlotte R. Flavell"'
Publikováno v:
Psychopharmacology
Rationale Pharmacological targeting of memory reconsolidation is a promising therapeutic strategy for the treatment of fear memory-related disorders. However, the success of reconsolidation-based approaches depends upon the effective destabilisation
Autor:
Charlotte R. Flavell, Xiang Li, Timothy W. Bredy, Qiongyi Zhao, Danay Baker-Andresen, Wei Wei, Yi Zhang, Ana C. D’Alessio, Jocelyn Widagdo
Publikováno v:
Li, X; Wei, W; Zhao, QY; Widagdo, J; Baker-Andresen, D; Flavell, CR; et al.(2014). Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation. Proceedings of the National Academy of Sciences of the United States of America, 111(19), 7120-7125. doi: 10.1073/pnas.1318906111. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/99w831x3
5-hydroxymethylcytosine (5-hmC) is a novel DNA modification that is highly enriched in the adult brain and dynamically regulated by neural activity. 5-hmC accumulates across the lifespan; however, the functional relevance of this change in 5-hmC and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10635d420d794077c01232d4d7a1b375
http://www.escholarship.org/uc/item/99w831x3
http://www.escholarship.org/uc/item/99w831x3
There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc5e117132b921bcf395af5be5f9f80
https://publications.aston.ac.uk/id/eprint/40206/1/Learn._Mem._2013_Baker_Andresen_237_40.pdf
https://publications.aston.ac.uk/id/eprint/40206/1/Learn._Mem._2013_Baker_Andresen_237_40.pdf
Publikováno v:
Nature communications
The reactivation of a memory through retrieval can render it subject to disruption or modification through the process of memory reconsolidation. In both humans and rodents, briefly reactivating a fear memory results in effective erasure by subsequen