Zobrazeno 1 - 10
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pro vyhledávání: '"Jonathan L.C. Lee"'
Publikováno v:
Learn Mem
The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear me
Publikováno v:
Psychopharmacology
Rationale Pharmacological targeting of memory reconsolidation is a promising therapeutic strategy for the treatment of fear memory-related disorders. However, the success of reconsolidation-based approaches depends upon the effective destabilisation
Publikováno v:
Behavioural Brain Research. 393:112774
Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus
Publikováno v:
Neurobiology of Learning and Memory. 104:25-31
When memories are retrieved, they can enter a labile state during which the memory may be modified and subsequently restabilized through the process of reconsolidation. However, this does not occur in all situations, and certain "boundary conditions"
Autor:
Jürgen Sandkühler, Jonathan L.C. Lee
Publikováno v:
Trends in Neurosciences
Highlights • Currently emerging concepts of maladaptive pain and fear suggest that they share basic neuronal circuits and cellular mechanisms of memory formation. • Recent studies have revealed processes of erasing memory traces of pain and fear
Autor:
Jonathan L.C. Lee, Amy C. Reichelt
Publikováno v:
Psychopharmacology. 226:649-658
Discrepancies in an expected outcome have been demonstrated to result in modification of behaviour in both appetitive and aversive conditioning settings. In this study, we sought to establish whether overexpectation generated from compound conditioni
Autor:
Jonathan L.C. Lee
Publikováno v:
Trends in Neurosciences. 32:413-420
The retrieval of a memory places it into a plastic state, the result of which is that the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within a framework of memories being reactivated and
Publikováno v:
Learningmemory (Cold Spring Harbor, N.Y.). 16(1)
Conditioned cue-induced relapse to drug seeking is a major challenge to the treatment of drug addiction. It has been proposed that D-cycloserine might be useful in the prevention of relapse by reducing the conditioned reinforcing properties of drug-a
Publikováno v:
Learningmemory (Cold Spring Harbor, N.Y.). 15(2)
We have investigated the neurochemical mechanisms of memory reconsolidation and, in particular, the functional requirement for intracellular mechanisms initiated by β-adrenergic signaling. We show that propranolol, given in conjunction with a memory
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(39)
NMDA receptors are important for the acquisition, reconsolidation, and extinction of memories. NMDA receptor antagonists impair these memory processes, whereas the partial agonistd-cycloserine (DCS) potentiates both learning and extinction. Here, we