Zobrazeno 1 - 10
of 11
pro vyhledávání: '"David Lyden"'
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Publikováno v:
Developmental Cell. 49:347-360
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and t
Publikováno v:
Cell. 170:223-225
Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although endogenous RNAs acting as damage-associated molecular patterns (DAMPs) for pattern recognition
Autor:
Martin P. Seybold, Han Sang Kim, Ayuko Hoshino, Knut M. Wittkowski, David Lyden, Christina Dadurian
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199012 (2018)
PLoS ONE, Vol 13, Iss 7, p e0199012 (2018)
Most breast cancer deaths are caused by metastasis and treatment options beyond radiation and cytotoxic drugs, which have severe side effects, and hormonal treatments, which are or become ineffective for many patients, are urgently needed. This study
Autor:
Mithat Gonen, Milica Tesic Mark, Ronald P. DeMatteo, Michael I. D’Angelica, Gokce Askan, T. Peter Kingham, Olca Basturk, Henrik Molina, Bruno Costa-Silva, Constantinos P. Zambirinis, Jonathan M. Hernandez, William R. Jarnagin, Linda Bojmar, David Lyden, Peter J. Allen, Elke J. A. H. van Beek, Alexandre Doussot, Jian Zheng
Background Exosomes are nanovesicles that have been shown to mediate carcinogenesis in pancreatic ductal adenocarcinoma (PDAC). Given the direct communication of pancreatic duct fluid with the tumor and its relative accessibility, we aimed to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008f77154cb09a219404989d7ef9bd99
https://europepmc.org/articles/PMC6779041/
https://europepmc.org/articles/PMC6779041/
Autor:
Claudia Savini, Laura Benedetta Amato, Basant Kumar Thakur, Jacqueline Bromberg, Giuseppe Gasparre, Chiara Mastroleo, Monica Cricca, Ivana Kurelac, Qing Chang, Massimiliano Bonafè, Kunihiro Uryu, Alexander Galkin, Anna Stepanova, Pasquale Sansone, Larry Norton, Nadine Soplop, David Lyden, Luisa Iommarini, Ayuko Hoshino, Laura Daly, Antonio Strillacci
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(43)
The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit from dormancy have never been investigated. Here we identified the full mitochondrial genome in circulating extracellular vesicles (EVs) from patients with h
Autor:
Joshua Mitchell Weiss, Han Sang Kim, Annette Becker, David Lyden, Basant Kumar Thakur, Héctor Peinado
Publikováno v:
Cancer cell. 30(6)
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and m
Autor:
Aru Narendran, Mary S. Brady, Haiying Zhang, Swarnima Singh, Mina J. Bissell, Joshua Mitchell Weiss, Angela Di Giannatale, Linda Bojmar, Maria de Sousa, Gonçalo Rodrigues, Volkmar Müller, Kavita Mallya, Gary K. Schwartz, Vinagolu K. Rajasekhar, Henrik Molina, Sukwinder Kaur, Michael A. Hollingsworth, Per Sandström, Alexander E. Davies, Shinji Kohsaka, Kimberly Kramer, Nadine Soplop, Andy J. Minn, Irina Matei, Lindsay A. Pharmer, Sophia Ceder, David Lyden, Benjamin A. Garcia, Jacqueline Bromberg, Tang-Long Shen, Elin H. Kure, Cyrus M. Ghajar, Héctor Peinado, Ayako Hashimoto, Knut Jørgen Labori, Caitlin Williams, William R. Jarnagin, Jonathan M. Hernandez, Vanessa D. Dumont-Cole, John H. Healey, Øystein Fodstad, Ayuko Hoshino, Yibin Kang, Yonathan Ararso, Klaus Pantel, Tari A. King, Tuo Zhang, Milica Tesic Mark, Leonard H. Wexler, Surinder K. Batra, Maneesh Jain, Paul M. Grandgenett, Bruno Costa-Silva, Kunihiro Uryu
Publikováno v:
Nature, vol 527, iss 7578
Nature
Hoshino, A; Costa-Silva, B; Shen, TL; Rodrigues, G; Hashimoto, A; Tesic Mark, M; et al.(2015). Tumour exosome integrins determine organotropic metastasis. Nature, 527(7578), 329-335. doi: 10.1038/nature15756. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/60s4z9wm
Nature
Hoshino, A; Costa-Silva, B; Shen, TL; Rodrigues, G; Hashimoto, A; Tesic Mark, M; et al.(2015). Tumour exosome integrins determine organotropic metastasis. Nature, 527(7578), 329-335. doi: 10.1038/nature15756. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/60s4z9wm
© 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8408ae12ab5df6d9b94376be7d65dc61
https://escholarship.org/uc/item/60s4z9wm
https://escholarship.org/uc/item/60s4z9wm
Autor:
Caitlin Williams, Kavita Mallya, Saya H. Ebbesen, Gonçalo Rodrigues, Henrik Molina, Irina Matei, Ayuko Hoshino, Annette Becker, William R. Jarnagin, Bruno Costa-Silva, Yujie Huang, Milica Tesic Mark, Inger Marie Bowitz Lothe, Nicole M. Aiello, Michael A. Hollingsworth, Tang-Long Shen, Guillermo García-Santos, Till Martin Theilen, Elin H. Kure, Yonathan Ararso, Haiying Zhang, Robert E. Schwartz, Alexandre Doussot, Allyson J. Ocean, Basant Kumar Thakur, Jonathan M. Hernandez, Knut Jørgen Labori, Paul M. Grandgenett, David Lyden, Ben Z. Stanger, Swarnima Singh, Maneesh Jain, Jenny Xiang, Tuo Zhang, Héctor Peinado, Jacqueline Bromberg, Surinder K. Batra
Publikováno v:
Nature cell biology. 17(6)
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes in
Autor:
Basant Kumar Thakur, Haiying Zhang, Annette Becker, Irina Matei, Yujie Huang, Bruno Costa-Silva, Yan Zheng, Ayuko Hoshino, Helene Brazier, Jenny Xiang, Caitlin Williams, Ruth Rodriguez-Barrueco, Jose M Silva, Weijia Zhang, Stephen Hearn, Olivier Elemento, Navid Paknejad, Katia Manova-Todorova, Karl Welte, Jacqueline Bromberg, Héctor Peinado, David Lyden
Publikováno v:
Cell Research
The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recoverin