Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dilraj Lama"'
Autor:
David P. Lane, Dilraj Lama, Christopher J. Brown, Serge Auvin, Tarig Bashir, Chandra S. Verma, Jessica Nakhle, Natia Tsomaia, Yuri Frosi, Anne-Marie Liberatore
Publikováno v:
'Chemical Science ', vol: 10, pages: 2489-2500 (2019)
Stapled-peptides have emerged as an exciting class of molecules which can modulate protein–protein interactions. We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high binding affinities and r
Intrinsically disordered regions (IDRs) in proteins can regulate their activity by facilitating protein-protein interactions (PPIs) as exemplified in the recruitment of the eukaryotic translation initiation factor 4E (eIF4E) protein by the protein eI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1bc06ba76d00e64d02eeec641eb0f00
https://doi.org/10.1101/2020.08.20.230268
https://doi.org/10.1101/2020.08.20.230268
Autor:
Dilraj Lama, Chandra S. Verma
Publikováno v:
Protein Sci
The mRNA cap-binding oncoprotein "eIF4E" is phosphorylated at residue S209 by Mnk kinases, and is closely associated with tumor development and progression. Despite being well-established, mechanistic details at the molecular level of mRNA recognitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f846c10e517344071ffa9b8996559e6
https://europepmc.org/articles/PMC7255503/
https://europepmc.org/articles/PMC7255503/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129775
Background Intrinsically disordered regions (IDRs) in proteins can regulate their activity by facilitating protein-protein interactions (PPIs) as exemplified in the recruitment of the eukaryotic translation initiation factor 4E (eIF4E) protein by the
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 33:102-103
Targeting undruggable protein-protein interacting sites has received a promising boost with the developments of an emerging class of peptidomimetics called stapled-peptides (Verdine & Hilinski, 201...