Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Evan R. Simpson"'
Autor:
Genevieve V. Dall, Jessica L. Vieusseux, Kenneth S. Korach, Yukitomo Arao, Sylvia C. Hewitt, Katherine J. Hamilton, Elaine Dzierzak, Wah Chin Boon, Evan R. Simpson, Robert G. Ramsay, Torsten Stein, Joanne S. Morris, Robin L. Anderson, Gail P. Risbridger, Kara L. Britt
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 417-431 (2017)
Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Since ERα
Externí odkaz:
https://doaj.org/article/451b048dd31a4d51af09091027b98444
Autor:
Kenneth S. Korach, Kara L. Britt, Joanne S. Morris, Genevieve V. Dall, Evan R. Simpson, Yukitomo Arao, Katherine J. Hamilton, Elaine Dzierzak, Gail P. Risbridger, Torsten Stein, Sylvia C. Hewitt, Robert G. Ramsay, Wah Chin Boon, Jessica L. Vieusseux, Robin L. Anderson
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 417-431 (2017)
Stem Cell Reports
Dall, G V, Vieusseux, J L, Korach, K S, Arao, Y, Hewitt, S C, Hamilton, K J, Dzierzak, E, Boon, W C, Simpson, E R, Ramsay, R G, Stein, T, Morris, J S, Anderson, R L, Risbridger, G P & Britt, K L 2017, ' SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24(+) CD49f(hi) Mammary Stem Cell-Enriched Compartment ', Stem Cell Reports, vol. 8, no. 2, pp. 417-431 . https://doi.org/10.1016/j.stemcr.2016.12.022
Stem Cell Reports
Dall, G V, Vieusseux, J L, Korach, K S, Arao, Y, Hewitt, S C, Hamilton, K J, Dzierzak, E, Boon, W C, Simpson, E R, Ramsay, R G, Stein, T, Morris, J S, Anderson, R L, Risbridger, G P & Britt, K L 2017, ' SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24(+) CD49f(hi) Mammary Stem Cell-Enriched Compartment ', Stem Cell Reports, vol. 8, no. 2, pp. 417-431 . https://doi.org/10.1016/j.stemcr.2016.12.022
Summary Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Si
Publikováno v:
Current Opinion in Pharmacology. 31:90-96
Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause. Adipose tissue undergoes important changes in obesity due to excess storage of lipids, leading to adipocyte cell death and the recruitment of macrophage
Publikováno v:
Comprehensive Physiology
As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) and inflammatory mediators, which have important implications in numerous obesity-associated diseases. Adipose tissues a
Publikováno v:
Life Sciences. 158:130-136
Controversy surrounds the gender basis of progression in chronic kidney disease. Unfortunately, most experimental studies addressing this question do not distinguish between direct effects of estrogen and indirect activation of estrogen receptors thr
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 145:179-186
Aromatase is the critical enzyme that converts androgens to estrogens. It is frequently highly expressed in the tumour bearing breast of women diagnosed with estrogen receptor positive tumours, resulting in dramatically increased local estrogen produ
Autor:
Gareth Baynam, Timothy W. Jones, Evan R. Simpson, Seungmin Ham, Kristy A. Brown, Sarah J Meachem, Adrian Charles, Catherine S. Choong, Nirukshi Udayanga Gunasinghe Samarajeewa
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 98:E1979-E1987
Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder that arises as a consequence of mutations in the STK11 gene that encodes LKB1. PJS males often have estrogen excess manifesting as gynecomastia and advanced bone age. We and others have p
Autor:
Kristy A. Brown, Evan R. Simpson
Publikováno v:
Molecular Endocrinology. 27:715-725
In addition to the spectrum of conditions known collectively as the Metabolic Syndrome, obesity is now recognized to be associated with increased risk of several cancers including colon, endometrial, and breast cancer. Obesity and carcinogenesis shar
Autor:
Maria Halabalaki, Chantal Beatrice Magne Nde, Job Tchoumtchoua, Dieudonné Njamen, Evan R. Simpson, Stéphane Zingue, Colin Clyne
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 2, Pp 120-131 (2013)
The present study aims to determine the estrogenicity of Millettia macrophylla, a Cameroonian medicinal plant, in ovariectomized rats and to investigate the underlying mechanisms, in order to justify scientifically its traditional use. To accomplish
Autor:
Stephen Tanee Fomum, Colin Clyne, Chantal Beatrice Magne Nde, Günter Vollmer, Evan R. Simpson, Jean Wandji, Dieudonné Njamen
Publikováno v:
European Journal of Pharmacology. 674:87-94
Plant-derived estrogen-like compounds, so called phytoestrogens, are given much attention due to their potential therapeutic use. In our previous work the ethylacetate extract of Erythrina lysistemon stem bark showed estrogenic effects on cell cultur