Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kelly A. Whelan"'
Autor:
Reshu Saxena, Alena Klochkova, Mary Grace Murray, Mohammad Faujul Kabir, Safiyah Samad, Tyler Beccari, Julie Gang, Kishan Patel, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cancers, Vol 11, Iss 11, p 1697 (2019)
Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of
Externí odkaz:
https://doaj.org/article/c5135756dbd14edfac8c4c10d50af5f7
Autor:
Amanda B. Muir, Jozef Madzo, Karami A, Hugh H. Huang, Kelsey Keith, Kathryn E. Hamilton, Murray Mg, Klochkova A, Mu A, Marie Pier Tetreault, Tatiana A. Karakasheva, Kelly A. Whelan, Jaroslav Jelinek, Kabir Mf, Saxena R, Cruz-Acuna R
Stratified squamous epithelium of the esophagus is comprised of basal keratinocytes that execute a terminal differentiation program in overlying suprabasal and superficial cell layers. Although morphologic progression coupled with expression of speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466a58736079a723cc38ac10bcd95315
https://doi.org/10.1101/2021.02.08.430312
https://doi.org/10.1101/2021.02.08.430312
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature communications. 13(1)
Although morphologic progression coupled with expression of specific molecular markers has been characterized along the esophageal squamous differentiation gradient, the molecular heterogeneity within cell types along this trajectory has yet to be cl
Autor:
Bailey Aaron, Masataka Shimonosono, Dominique Bailey, Takeo Hara, Julian A. Abrams, Kathryn E. Hamilton, Yuta Kasagi, Veronique Giroux, Hiroshi Nakagawa, Jonathan M. Spergel, Gary W. Falk, Amanda B. Muir, Tatiana A. Karakasheva, Seema S. Aceves, Kelly A. Whelan, Takashi Kijima, Benjamin J. Wilkins
Publikováno v:
Curr Protoc Stem Cell Biol
The homeostatic proliferation-differentiation gradient in the esophageal epithelium is perturbed under inflammatory disease conditions such as gastroesophageal reflux disease and eosinophilic esophagitis. Herein we describe the protocols for rapid ge
Autor:
Kelly A. Whelan, Benjamin J. Wilkins, Okan U. Elci, Evan S. Dellon, Gary W. Falk, Jonathan Gross, Bridget Godwin, Andres J. Klein-Szanto, Hiroshi Nakagawa, Jonathan M. Spergel, Maureen DeMarshall, Amanda B. Muir, Medha Sharma, Alain Benitez, Chris A. Liacouras
Publikováno v:
Clin Gastroenterol Hepatol
Background & Aims Although eosinophil count is the standard used to monitor disease activity in patients with eosinophilic esophagitis (EoE), there are often disparities between patient-reported symptoms and eosinophil counts. We examined the prevale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caf01105763de1fa0d9d57e16578429
https://europepmc.org/articles/PMC7058491/
https://europepmc.org/articles/PMC7058491/
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 461-478 (2018)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
The stratified squamous epithelium of the esophagus shows a proliferative basal layer of keratinocytes that undergo terminal differentiation in overlying suprabasal layers. Esophageal pathologies, including eosinophilic esophagitis, gastroesophageal
Publikováno v:
Cancer Research. 81:1752-1752
A negative correlation between allergic inflammation and cancer risk has been identified in a variety of organs via population-based studies; however, functional investigations are necessary to define the relationship between allergy and cancer and d
Autor:
Kelly A. Whelan, Hiroshi Nakagawa
Publikováno v:
Microbiome and Cancer ISBN: 9783030041540
Comprising two primary histological subtypes, esophageal squamous cell carcinoma and esophageal adenocarcinoma, esophageal cancer remains among the most aggressive forms of human malignancy. Despite advances in our understanding of the genetic landsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b9aa893dfdedacd980da936f051bd9a
https://doi.org/10.1007/978-3-030-04155-7_3
https://doi.org/10.1007/978-3-030-04155-7_3
Autor:
Dorottya Laczkó, Divya Rao, Khvaramze Shaverdashvili, Kelly A. Whelan, Amanda B. Muir, Daniel Weinblatt, Wenpeng Jiang, Jennie Padlo, Jonathan P. Katz, Yang Jia, John P. Lynch
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215746 (2019)
Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcr
Autor:
Manti Guha, Prasanna M. Chandramouleeswaran, Andres J. Klein-Szanto, James Garifallou, Clementina Mesaros, Hiroshi Nakagawa, Renata Pellegrino da Silva, Ian A. Blair, Noah Engel, Eishi Noguchi, Joseph A. Baur, Masataka Shimonosono, Hakon Hakonarson, Uma M. Sachdeva, Gordon Ruthel, Michael Gonzalez, Shinya Ohashi, Hisatsugu Maekawa, Kelly A. Whelan, Sarmistha Mukherjee
Publikováno v:
BASE-Bielefeld Academic Search Engine
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While