Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Catherine L. Drennan"'
Publikováno v:
Science
Caught in the act Proton-coupled electron transfer (PCET) is an important process for moving electrons through proteins and requires precise positioning of suitable proton and electron carriers. Kang et al. determined a cryo–electron microscopy str
Publikováno v:
The Journal of Biological Chemistry
Pyruvate formate-lyase (PFL) is a glycyl radical enzyme (GRE) that converts pyruvate and coenzyme A into acetyl-CoA and formate in a reaction that is crucial to the primary metabolism of many anaerobic bacteria. The glycyl radical cofactor, which is
Autor:
Sarah E. J. Bowman, Lindsey R. F. Backman, Rebekah E. Bjork, Mary C. Andorfer, Santiago Yori, Alessio Caruso, Collin M. Stultz, Catherine L. Drennan
Publikováno v:
PMC
J Biol Inorg Chem
J Biol Inorg Chem
Glycyl radical enzymes (GREs) utilize a glycyl radical cofactor to carry out a diverse array of chemically challenging enzymatic reactions in anaerobic bacteria. Although the glycyl radical is a powerful catalyst, it is also oxygen sensitive such tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d80c3d19a7f863e84697336fe954fe
https://hdl.handle.net/1721.1/129986
https://hdl.handle.net/1721.1/129986
Autor:
Tsehai A.J. Grell, Benjamin N. Bell, Chi Nguyen, Daniel P. Dowling, Nathan A. Bruender, Vahe Bandarian, Catherine L. Drennan
Publikováno v:
Protein science : a publication of the Protein Society. 28(1)
7‐Carboxy‐7‐deazaguanine synthase, QueE, catalyzes the radical mediated ring contraction of 6‐carboxy‐5,6,7,8‐tetrahydropterin, forming the characteristic pyrrolopyrimidine core of all 7‐deazaguanine natural products. QueE is a member o
Autor:
Qinghui, Lin, Mackenzie J, Parker, Alexander T, Taguchi, Kanchana, Ravichandran, Albert, Kim, Gyunghoon, Kang, Jimin, Shao, Catherine L, Drennan, JoAnne, Stubbe
Publikováno v:
The Journal of biological chemistry. 292(22)
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleoside diphosphate substrates (S) to deoxynucleotides with allosteric effectors (e) controlling their relative ratios and amounts, crucial for fidelity of DNA replication and repair. Esc
Autor:
Nidhi Shrivastav, Catherine L. Drennan, Deyu Li, James C. Delaney, Bogdan I. Fedeles, Xuedong Yang, John M. Essigmann, Cintyu Wong
Publikováno v:
Chemical Research in Toxicology
The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alk
Autor:
Colin D. Douglas, Andrew M. Sydor, Catherine L. Drennan, Katherine S. Ryan, Kaitlyn E. Turo, Deborah B. Zamble, Marco Jost
Publikováno v:
Biochemistry
GTPases are critical molecular switches involved in a wide range of biological functions. Recent phylogenetic and genomic analyses of the large, mostly uncharacterized COG0523 subfamily of GTPases revealed a link between some COG0523 proteins and met
Autor:
Sean Elliott, Cintyu Wong, Nicholas C. Bene, Marco Jost, Catherine L. Drennan, Michael J. Hamill
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 12, Pp 16899-16915 (2012)
International Journal of Molecular Sciences
Volume 13
Issue 12
Pages 16899-16915
MDPI Publishing
International Journal of Molecular Sciences
Volume 13
Issue 12
Pages 16899-16915
MDPI Publishing
When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions has been well characteriz
Autor:
Michael A. Funk, Catherine L. Drennan, Paul A. Stucky, Kanchana R. Ravichandran, R. David Britt, Troy A. Stich, JoAnne Stubbe, Paul H. Oyala
Publikováno v:
Journal of the American Chemical Society, vol 138, iss 25
Journal of the American Chemical Society
Journal of the American Chemical Society
Fluorinated tyrosines (FnY's, n = 2 and 3) have been site-specifically incorporated into E. coli class Ia ribonucleotide reductase (RNR) using the recently evolved M. jannaschii Y-tRNA synthetase/tRNA pair. Class Ia RNRs require four redox active Y's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e713c51414d652a90fd490524a42e092
https://escholarship.org/uc/item/6xq240qk
https://escholarship.org/uc/item/6xq240qk
Autor:
Zachary T. Humulock, Xuedong Yang, Qi Tang, Deyu Li, Catherine L. Drennan, Marco Jost, Fangyi Chen, Ke Bian, John M. Essigmann
Publikováno v:
Chemical research in toxicology. 29(4)
The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently i