Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert A. Lazarus"'
Autor:
Paul Moran, Mark Peek, Racquel Corpuz, Charles Eigenbrot, Daniel Kirchhofer, Wei Li, Robert A. Lazarus, Jennifer Stamos, Saloumeh Kadkhodayan, J. Michael Elliott
Publikováno v:
Journal of Biological Chemistry. 278:36341-36349
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is an integral membrane protein expressed on epithelial cells and contains two extracellular Kunitz domains (N-terminal KD1 and C-terminal KD2) known to inhibit trypsin-like serine proteases. In
Publikováno v:
Journal of Biological Chemistry. 270:25411-25417
Phage displaying APPI Kunitz domain libraries have been used to design potent and selective active site inhibitors of human plasma kallikrein, a serine protease that plays an important role in both inflammation and coagulation. Selected clones from t
Publikováno v:
Biochemistry. 34:10383-10392
Surface plasmon resonance (SPR) measurements on a BIAcore instrument have been used to measure the effects of mutations in human tissue factor (TF), the initiator of blood coagulation, on the kinetics and affinity of binding to human FVIIa. TF mutant
Publikováno v:
Protein science : a publication of the Protein Society. 9(8)
Decorsin is an antagonist of integrin alphaIIbbeta3 and a potent platelet aggregation inhibitor. A synthetic gene encoding decorsin, originally isolated from the leech Macrobdella decora, was designed, constructed, and expressed in Escherichia coli.
Autor:
Daniel G. Yansura, Barbara Moffat, Dorothea Reilly, Mark S. Dennis, Robert N. Lindquist, Mary E. Wessinger, Robert A. Lazarus, Jana L. Seymour
Publikováno v:
Biochemistry. 33(13)
Ecotin, a serine protease inhibitor found in the periplasm of Escherichia coli, has been characterized as an extremely potent anticoagulant and reversible tight-binding inhibitor of human factor Xa (FXa). The ecotin gene was cloned by PCR, highly exp
Publikováno v:
Proteins. 15(3)
The binding interactions between platelet fibrinogen receptor, glycoprotein (GP) IIb-IIIa, and kistrin, a snake venom disintegrin protein that contains the adhesion site recognition sequence Arg-Gly-Asp (RGD) and potently inhibits platelet aggregatio
Autor:
David A. Estell, Jana L. Seymour, Jeffrey V. Miller, Kevin Stafford, Stephen Anderson, William Harry Rastetter, Robert A. Lazarus, David R. Light, Cara B. Marks
Publikováno v:
Science. 230:144-149
A new metabolic pathway has been created in the microorganism Erwinia herbicola that gives it the ability to produce 2-keto-L-gulonic acid, an important intermediate in the synthesis of L-ascorbic acid. Initially, a Corynebacterium enzyme that could
Publikováno v:
FEBS Letters. (2-3):159-163
Ecotin, a serine protease inhibitor found in the periplasm of Escherichia coli , has been characterized as a potent reversible tight-binding inhibitor of the human contact activation proteases factor XIIa (FXIIa) and plasma kallikrein, having K i val