Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Catherine L. Drennan"'
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Publikováno v:
eLife. 11
Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectr
Autor:
Talya S. Levitz, Gisele A. Andree, Rohan Jonnalagadda, Christopher D. Dawson, Rebekah E. Bjork, Catherine L. Drennan
Publikováno v:
PloS one. 17(6)
Ribonucleotide reductases (RNRs) use radical-based chemistry to catalyze the conversion of all four ribonucleotides to deoxyribonucleotides. The ubiquitous nature of RNRs necessitates multiple RNR classes that differ from each other in terms of the p
Publikováno v:
Journal of structural biology. 214(1)
Ribonucleotide reductase (RNR) is an essential enzyme that converts ribonucleotides to deoxyribonucleotides and is a promising antibiotic target, but few RNRs have been structurally characterized. We present the use of the chameleon, a commercially-a
Autor:
M. Dumble, Kanchana R. Ravichandran, Christopher J. Chang, Catherine L. Drennan, J. Hedrick, Michael Arnold, J. Wang, G. Chen, T. S. Levitz, S. Letinski, J. Narasimhan, A. Branstrom, A. Gerasyuto, Gary Mitchell Karp, JoAnne Stubbe, S. Jung
Antibiotic resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b47d759b4635c34c0cc90d75813787f
https://doi.org/10.1101/2020.11.19.389957
https://doi.org/10.1101/2020.11.19.389957
Autor:
Maanasa Narayanamoorthy, Chaoxiang Ren, Antonio Del Rio Flores, Jan Paulo T. Zaragoza, Wenjun Zhang, Heather J. Kulik, Wenlong Cai, Rimsha Mehmood, Rohan Jonnalagadda, Catherine L. Drennan
Publikováno v:
The Journal of Biological Chemistry
Elsevier
Elsevier
The isonitrile moiety is found in marine sponges and some microbes, where it plays a role in processes such as virulence and metal acquisition. Until recently only one route was known for isonitrile biosynthesis, a condensation reaction that brings t
Publikováno v:
The Journal of Biological Chemistry
Pyruvate formate-lyase (PFL) is a glycyl radical enzyme (GRE) that converts pyruvate and coenzyme A into acetyl-CoA and formate in a reaction that is crucial to the primary metabolism of many anaerobic bacteria. The glycyl radical cofactor, which is
Autor:
Clorice R, Reinhardt, Pengfei, Li, Gyunghoon, Kang, JoAnne, Stubbe, Catherine L, Drennan, Sharon, Hammes-Schiffer
Publikováno v:
J Am Chem Soc
Ribonucleotide reductses (RNRs) catalyze the conversion of all four ribonucleotides to deoxyribonucleotides and are essential for DNA synthesis in all organisms. The active form of E. coli Ia RNR is composed of two homodimers that form the active α2
Autor:
Marina Bennati, Brandon L. Greene, Gyunghoon Kang, Daniel G. Nocera, Catherine L. Drennan, Chang Cui, JoAnne Stubbe
Publikováno v:
Annual review of biochemistry, vol 89, iss 1
PMC
Annu Rev Biochem
PMC
Annu Rev Biochem
© 2020 Annual Reviews Inc.. All rights reserved. Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing so, they play an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bded6ce893cb82e3fe193b1f28d274
https://escholarship.org/uc/item/66n1v898
https://escholarship.org/uc/item/66n1v898
Publikováno v:
Journal of Biological Chemistry. 293:10404-10412
Ribonucleotide reductases (RNRs) convert ribonucleotides to deoxynucleotides, a process essential for DNA biosynthesis and repair. Class Ia RNRs require two dimeric subunits for activity: an α2 subunit that houses the active site and allosteric regu
Autor:
Alexander T. Taguchi, Qinghui Lin, Kanchana R. Ravichandran, Gyunghoon Kang, Mackenzie J. Parker, Catherine L. Drennan, Jimin Shao, JoAnne Stubbe, Albert H. Kim
Publikováno v:
Journal of Biological Chemistry. 292:9229-9239
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleoside diphosphate substrates (S) to deoxynucleotides with allosteric effectors (e) controlling their relative ratios and amounts, crucial for fidelity of DNA replication and repair. Esc