Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sven Perner"'
Autor:
Klaus Jung, Sven Perner, Carsten Stephan, Nicolas Wernert, Martin Braun, Glen Kristiansen, Matteo Montani, Manfred Dietel, Diane Goltz
Publikováno v:
Pathology. 47:629-636
Summary We evaluated the prognostic value of the mitosis-associated marker phosphorylated histone H3 (PHH3) and Ki-67 in prostate cancer with respect to ERG status and androgen receptor (AR) expression. PHH3 and Ki-67 expression was immunohistochemic
Autor:
Gisela Helenius, Jack Groskopf, Maria A. Svensson, Francesca Demichelis, Thomas Sollie, Sven Perner, Swen-Olof Andersson, Robert Kirsten, John R. Day, Anna-Lena Ohlson, Mark A. Rubin, Ove Andrén
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 22:136-141
The ERG rearrangement is identified in approximately 50% of prostate cancer screened cohorts and is known to be highly specific. This genetic aberration, most commonly leading to the TMPRSS2-ERG fusion, but also SLC45A3-ERG or NDRG1-ERG fusions, all
Autor:
Christian Ruiz, Sven Perner, Albert Dobi, Shiv Srivastava, Isabell A. Sesterhenn, Martin Braun, Alexander Bachmann, Veit Scheble, Lukas Bubendorf, Tobias Zellweger, Shyh-Han Tan, Joel R. Gsponer, Meera Srivastava, Tatjana Vlajnic
Publikováno v:
Prostate Cancer and Prostatic Diseases. 17:126-131
Approximately half of the prostate carcinomas are characterized by a chromosomal rearrangement fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG. Aim of this study was to comprehensively analyze the role and imp
Autor:
Nicolas Wernert, Diana Boehm, Martin Braun, Falko Fend, Zaki Shaikhibrahim, Pavel Nikolov, Veit Scheble, Glen Kristiansen, Roopika Menon, Sven Perner
Publikováno v:
Human Pathology. 43:1910-1916
ETS gene rearrangements are frequently found in prostate cancer. Several studies have assessed the rearrangement status of the most commonly found ETS rearranged gene ERG, and the less frequent genes, ETV-1, ETV-4, ETV-5, and ELK-4 in primary prostat
Autor:
Manfred Dietel, Nicolas Wernert, Carsten Stephan, Klaus Jung, Niels J. Rupp, Sven Perner, Martin Braun, Holger Moch, Mark A. Rubin, Glen Kristiansen
Publikováno v:
International Journal of Cancer. 132:807-812
The majority of prostate cancer harbors recurrent gene fusions involving ETS transcription factors, most commonly ERG. The second most common 5' fusion partner after TMPRSS2 is SLC45A3. The aim of our study was to quantify the protein expression of E
Autor:
Alexander Bachmann, Martin Braun, Karen Petersen, Falko Fend, Sven Perner, Gregor Scharf, Nicolas Wernert, Glen Kristiansen, Veit Scheble, Tobias Zellweger, Zaki Shaikhibrahim, Susanna Stürm, Christian Ruiz, Rudi Beschorner, Lukas Bubendorf
Publikováno v:
Virchows Archiv. 461:157-162
Castration-resistant prostate cancer is the second most common cause of cancer death and results in a median survival of less than 2 years. In prostate cancer, fusions between TMPRSS2 and ERG are common. The ERG rearrangement prevalence in local recu
Autor:
Diana Boehm, Zaki Shaikhibrahim, Martin Braun, Nicolas Wernert, Wenzel Vogel, Veit Scheble, Falko Fend, Sven Perner, Julia Stomper, Glen Kristiansen
Publikováno v:
The Journal of Molecular Diagnostics. 14:322-327
The recently detected TMPRSS2-ERG fusion gene was revealed as a recurrent and prevalent prostate cancer (PCa)-specific event, potentially qualifying it for clinical use. To detect this alteration, fluorescence in situ hybridization (FISH) is the meth
Autor:
Rainer Kuefer, Karen Petersen, Theresia Wilbertz, Falko Fend, Gregor Scharf, Arnulf Stenzl, Christine Beschorner, Markus Reischl, Mark A. Rubin, Glen Kristiansen, Roopika Menon, Martin Braun, Veit Scheble, David Schilling, Sven Perner
Publikováno v:
Histopathology. 58:1028-1036
Braun M, Scheble V J, Menon R, Scharf G, Wilbertz T, Petersen K, Beschorner C, Reischl M, Kuefer R, Schilling D, Stenzl A, Kristiansen G, Rubin M A, Fend F & Perner S (2011) Histopathology 58, 1028–1036 Relevance of cohort design for studying the f
Autor:
Francesca Demichelis, David S. Rickman, Mark A. Rubin, Kanishka Sircar, Arul M. Chinnaiyan, Tarek A. Bismar, Jindan Yu, Sunita R. Setlur, Sven Perner, Ying bei Chen, Kirsten D. Mertz, Terry Vuong, Samprit Banerjee, Christopher J. LaFargue, Yihang Pan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 12, Pp 1031-1040 (2010)
To elucidate the role of ETS gene fusions in castration-resistant prostate cancer (CRPC), we characterized the transcriptome of 54 CRPC tumor samples from men with locally advanced or metastatic disease. Trefoil factor 3 (TFF3) emerged as the most hi
Autor:
Ann-Cathrin Stiedl, Falko Fend, Theresia Wilbertz, Gerhard Seitz, Sven Perner, Martin Braun, David Schilling, Karen Petersen, Glen Kristiansen, Veit Scheble, Markus Reischl
Publikováno v:
Histopathology. 56:937-943
Scheble V J, Braun M, Wilbertz T, Stiedl A-C, Petersen K, Schilling D, Reischl M, Seitz G, Fend F, Kristiansen G & Perner S (2010) Histopathology 56, 937–943 ERG rearrangement in small cell prostatic and lung cancer Aims: Small cell prostatic cance