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pro vyhledávání: '"Zawia, A"'
Publikováno v:
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
IntroductionEarly life lead (Pb) exposure results in a latent increase in Alzheimer's disease (AD)–related proteins, and cognitive deficits late in life in both rodents and primates. This study was conducted to investigate if these late life change
Autor:
Christopher Hemme, Ronald P. Hart, John M. Gaspar, Aseel Eid, Syed Waseem Bihaqi, Nasser H. Zawia
Publikováno v:
Epigenomics. 10(5)
Aim: Early life exposure to lead (Pb) has been shown to increase late life biomarkers involved in Alzheimer's disease (AD) pathology. Here, we tested the hypothesis that latent over expression of AD-related genes may be regulated through histone acti
Autor:
Syed Waseem Bihaqi, William E. Renehan, Bothaina Alansi, Anwar Masoud, Nasser H. Zawia, Miriam Dash, Gehad M. Subaiea
Amyloid deposits originating from the amyloid-β protein precursor (AβPP) and aggregates of the microtubule associated protein tau (MAPT) are the hallmarks of Alzheimer's disease (AD). Animal studies have demonstrated a link between early life expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f65d2a783e5ca9a6e53d4090dd67b35
https://europepmc.org/articles/PMC7092362/
https://europepmc.org/articles/PMC7092362/
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Akademický článek
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Autor:
Lina Adwan, Nasser H. Zawia
Publikováno v:
Pharmacology & Therapeutics. 139:41-50
Alzheimer's disease (AD) is the most common type of dementia in the elderly. It is characterized by the deposition of two forms of aggregates within the brain, the amyloid β plaques and tau neurofibrillary tangles. Currently, no disease-modifying ag
Publikováno v:
NeuroToxicology. 33:1450-1453
The progressive and latent nature of neurodegenerative diseases, such as Alzheimer’s disease (AD) indicates the role of epigenetic modification in disease susceptibility. Previous studies from our lab show that developmental exposure to lead (Pb) p
Publikováno v:
Journal of Alzheimer's disease : JAD. 51(4)
There is a growing recognition of the impact of environmental toxins on the epigenetic regulation of gene expression, including the genes that play a critical role in neural development, neural function, and neurodegeneration. We have shown previousl
Autor:
Nasser H. Zawia, Aseel Eid
Publikováno v:
Neurotoxicology. 56
Lead exposure has primarily been a concern during development in young children and little attention has been paid to exposure outcomes as these children age, or even to exposures in adulthood. Childhood exposures have long term consequences, and adu
Publikováno v:
Journal of Alzheimer's Disease. 27:819-833
The beginnings of late onset Alzheimer's disease (LOAD) are still unknown; however, the progressive and latent nature of neurodegeneration suggests that the triggering event occurs earlier in life. Aging primates exposed to lead (Pb) as infants exhib