Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Barbara McKnight"'
Autor:
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Plasma ceramides and sphingomyelins have been independently linked to diabetes risk, glucose and insulin levels, and the risk of several cardiovascular (CVD) outcomes. However, whether individual ceramide and sphingomyelin species
Externí odkaz:
https://doaj.org/article/54129391a2444a28a02c387c62d4d169
Autor:
Rozenn N. Lemaitre, Paul N. Jensen, Maxwell Zeigler, Amanda M. Fretts, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M. Psaty, Nona Sotoodehnia, Rheem A. Totah
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104189- (2022)
Summary: Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and p
Externí odkaz:
https://doaj.org/article/2df301d177d4451f903cbf396c53c760
Autor:
Rozenn N. Lemaitre, Paul N Jensen, Maxwell Zeigler, Julie Denham, Amanda M. Fretts, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M Psaty, Nona Sotoodehnia, Rheem A. Totah
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103279- (2021)
Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid with multiple biological functions. Rodent experiments suggest EETs play a role in insulin sensitivity and diabetes, but evidence in humans is limited. To address this k
Externí odkaz:
https://doaj.org/article/40e9401f43b9490eb1ea7c2ed4507c38
Autor:
Amanda M. Fretts, Paul N. Jensen, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Luc Djousse, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100119- (2021)
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bo
Externí odkaz:
https://doaj.org/article/0917e90c47af468fb367acaaa4679314
Autor:
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Colleen M. Sitlani, Barbara McKnight, Irena B. King, David S. Siscovick, Bruce M. Psaty, Susan R. Heckbert, Dariush Mozaffarian, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 4 (2020)
Background Ceramides exhibit multiple biological activities that may influence the pathophysiological characteristics of atrial fibrillation (AF). Whether the length of the saturated fatty acid carried by the ceramide or their sphingomyelin precursor
Externí odkaz:
https://doaj.org/article/5c2477103db34a5db919e16aaa13c4c6
Circulating Very Long‐Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study
Autor:
Rozenn N. Lemaitre, Barbara McKnight, Nona Sotoodehnia, Amanda M. Fretts, Waqas T. Qureshi, Xiaoling Song, Irena B. King, Colleen M. Sitlani, David S. Siscovick, Bruce M. Psaty, Dariush Mozaffarian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 21 (2018)
Background Circulating very‐long‐chain saturated fatty acids (VLSFAs) are integrated biomarkers of diet and metabolism that may point to new risk pathways and potential targets for heart failure (HF) prevention. The associations of VLSFA to HF in
Externí odkaz:
https://doaj.org/article/085da2f009024fd9b35b882240271994
Autor:
Rozenn N. Lemaitre, Traci M. Bartz, Irena B. King, Jennifer A. Brody, Barbara McKnight, Nona Sotoodehnia, Thomas D. Rea, Catherine O. Johnson, Dariush Mozaffarian, Stephanie Hesselson, Pui-Yan Kwok, David S. Siscovick
Publikováno v:
Journal of Nutritional Science, Vol 5 (2016)
Whether genetic factors influence the associations of fatty acids with the risk of sudden cardiac arrest (SCA) is largely unknown. To investigate possible gene–fatty acid interactions on SCA risk, we used a case-only approach and measured fatty aci
Externí odkaz:
https://doaj.org/article/406ec61c5aa64495ae48594ce1073684
Autor:
Thomas R. Austin, Caitlin P. McHugh, Jennifer A. Brody, Joshua C. Bis, Colleen M. Sitlani, Traci M. Bartz, Mary L. Biggs, Nisha Bansal, Petra Buzkova, Steven A. Carr, Christopher R. deFilippi, Mitchell S. V. Elkind, Howard A. Fink, James S. Floyd, Alison E. Fohner, Robert E. Gerszten, Susan R. Heckbert, Daniel H. Katz, Jorge R. Kizer, Rozenn N. Lemaitre, W. T. Longstreth, Barbara McKnight, Hao Mei, Kenneth J. Mukamal, Anne B. Newman, Debby Ngo, Michelle C. Odden, Ramachandran S. Vasan, Ali Shojaie, Noah Simon, George Davey Smith, Neil M. Davies, David S. Siscovick, Nona Sotoodehnia, Russell P. Tracy, Kerri L. Wiggins, Jie Zheng, Bruce M. Psaty
Publikováno v:
Austin, T R, McHugh, C P, Brody, J A, Bis, J C, Sitlani, C M, Bartz, T M, Biggs, M L, Bansal, N, Buzkova, P, Carr, S A, deFilippi, C R, Elkind, M SV, Fink, H A, Floyd, J S, Fohner, A E, Gerszten, R E, Heckbert, S R, Katz, D H, Kizer, J R, Lemaitre, R N, Longstreth, W T, McKnight, B, Mei, H, Mukamal, K J, Newman, A B, Ngo, D, Odden, M C, Vasan, R S, Shojaie, A, Etkind, S N, Davey Smith, G, Davies, N M, Siscovick, D S, Sotoodehnia, N, Tracy, R P, Wiggins, K L, Zheng, J & Psaty, B M 2022, ' Proteomics and Population Biology in the Cardiovascular Health Study (CHS) : design of a study with mentored access and active data sharing ', European Journal of Epidemiology, vol. 37, pp. 755–765 . https://doi.org/10.1007/s10654-022-00888-z
BackgroundIn the last decade, genomic studies have identified and replicated thousands of genetic associations with measures of health and disease and contributed to the understanding of the etiology of a variety of health conditions. Proteins are ke
Autor:
Nona Sotoodehnia, Dariush Mozaffarian, Matthew J. Budoff, Amanda M. Fretts, Yujin Lee, Ina Nemet, Joseph A. DiDonato, Rozenn N. Lemaitre, Barbara McKnight, Zeneng Wang, W.H. Wilson Tang, Heidi T. M. Lai, Marcia C de Oliveira Otto, Stanley L. Hazen, David S. Siscovick, Bruce M. Psaty
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Journal of the American Heart Association, vol 10, iss 17
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Journal of the American Heart Association, vol 10, iss 17
Background Trimethylamine N‐oxide (TMAO) is a gut microbiota‐dependent metabolite of dietary choline, L‐carnitine, and phosphatidylcholine‐rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma T
Autor:
Lin Y. Chen, Barbara N. Harding, Barbara McKnight, Susan R. Heckbert, Bruce M. Psaty, James S. Floyd, Elsayed Z. Soliman, Faye L. Norby
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 11 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 11 (2021)
Background High blood pressure (BP) is a well‐known risk factor for atrial fibrillation (AF), but a single BP measurement may provide limited information about AF risk in older adults. Methods and Results This study included 1256 MESA (Multi‐Ethn