Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daisuke Ogasawara"'
Autor:
Ran, Cheng, Masayuki, Fujinaga, Jing, Yang, Jian, Rong, Ahmed, Haider, Daisuke, Ogasawara, Richard S, Van, Tuo, Shao, Zhen, Chen, Xiaofei, Zhang, Erick R, Calderon Leon, Yiding, Zhang, Wakana, Mori, Katsushi, Kumata, Tomoteru, Yamasaki, Lin, Xie, Shaofa, Sun, Lu, Wang, Chongzhao, Ran, Yihan, Shao, Benjamin, Cravatt, Lee, Josephson, Ming-Rong, Zhang, Steven H, Liang
Publikováno v:
Acta pharmacologica Sinica. 43(11)
Monoacylglycerol lipase (MAGL) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA). As such, selective inhibition
Autor:
Jian Rong, Tuo Shao, Xiaofei Zhang, Jun-An Ma, Mikhail Papisov, Yiding Zhang, Genwei Zhang, Zhen Chen, Masayuki Fujinaga, Yihan Shao, Xiaoyun Deng, Daisuke Ogasawara, Lu Wang, Michael A. Schafroth, Ming-Rong Zhang, Akiko Hatori, Qingzhen Yu, Richard Van, Thomas Lee Collier, Hualong Fu, Kuan Hu, Vasily Belov, Benjamin F. Cravatt, Wakana Mori, Pilar Giffenig, Steven H. Liang, Lee Josephson
Publikováno v:
J Med Chem
Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize and evaluate several irreversible fluorine-containing MAGL in
Autor:
Gabriel M. Simon, Pablo Lara-Gonzalez, Benjamin F. Cravatt, Kenneth M. Lum, Michael Petrascheck, Daisuke Ogasawara, Arshad Desai, William H. Parsons, Armand B. Cognetta, Liron Bar-Peled, Alice L Chen, Alan To
Publikováno v:
Nature Chemical Biology. 15:453-462
Phenotypic screening has identified small-molecule modulators of aging, but the mechanism of compound action often remains opaque due to the complexities of mapping protein targets in whole organisms. Here, we combine a library of covalent inhibitors
Autor:
Yiding Zhang, Zhen Chen, Ran Cheng, Tuo Shao, Yihan Shao, Qingzhen Yu, Jun-An Ma, Kuan Hu, Xiaoyun Deng, Akiko Hatori, Steven H. Liang, Lee Josephson, Hualong Fu, Kenneth Dahl, Neil Vasdev, Michael A. Schafroth, Masayuki Fujinaga, Lin Xie, Christopher J. Fowler, Shuyin Gu, Thomas Lee Collier, Lu Wang, Benjamin F. Cravatt, Jian Rong, Daisuke Ogasawara, Tomoteru Yamasaki, Bao Liang, Yuancheng Gou, Ming-Rong Zhang, Xiaofei Zhang, Katsushi Kumata, Genwei Zhang, Wakana Mori, Jingjin Chen
Publikováno v:
Journal of Medicinal Chemistry. 62:3336-3353
Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathologic
Autor:
Benjamin F. Cravatt, Jonathan J. Hulce, Daisuke Ogasawara, Taka-Aki Ichu, Alex Reed, Olesya A. Ulanovskaya, Hui Jing
Publikováno v:
Journal of Medicinal Chemistry. 62:1643-1656
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lyso-phosphatidylserine (lyso-PS) and lyso-phosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/P
Autor:
Christopher W. am Ende, Uthpala Seneviratne, Zhen Huang, Armand B. Cognetta, Douglas S. Johnson, Daisuke Ogasawara, Kimberly Lapham, Benjamin F. Cravatt, John Litchfield, Deane M. Nason
Publikováno v:
ACS Chemical Biology. 14:192-197
Clinical investigation of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10–2474 resulted in serious adverse neurological events. Structurally unrelated FAAH inhibitors tested in humans have not presented safety concerns, suggesting that BIA 1
Autor:
Jacqueline R. Benthuysen, Vincent F. Vartabedian, Alex Reed, Hugh Rosen, Benjamin F. Cravatt, Amanda J. Roberts, Daisuke Ogasawara, Olesya A. Ulanovskaya, Hui Jing, Taka-Aki Ichu, Jonathan J. Hulce, John R. Teijaro, Steven D. Brown
Publikováno v:
Nature chemical biology
ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12(−/−) mice display PHARC-like phenotypes, including hearing loss, al
Autor:
Steven H. Liang, Michael A. Schafroth, Jian Rong, Ahmed Haider, Linjing Mu, Daisuke Ogasawara, Cassis Varlow, Hao Xu, Christopher J. Fowler, Neil Vasdev, Lu Hou, Jiefeng Gan, Lu Wang, Benjamin F. Cravatt, Ming-Rong Zhang, Simon M. Ametamey
Publikováno v:
J Med Chem
The endocannabinoid system (ECS) is involved in a wide range of biological functions and is comprised of cannabinoid receptors and enzymes responsible for endocannabinoid synthesis and degradation. Over the past two decades, significant advances towa
Autor:
Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
Publikováno v:
Nature Chemical Biology, 16(6), 667-675
Nat Chem Biol
Nat Chem Biol
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858eb516053df2c6e71eaf7ba6acceef
https://www.nature.com/articles/s41589-020-0528-7
https://www.nature.com/articles/s41589-020-0528-7
Autor:
Hui Deng, Marc P. Baggelaar, Adrianus M. C. H. van den Nieuwendijk, Hans den Dulk, Herman S. Overkleeft, Richard J. B. H. N. van den Berg, Tom van der Wel, Floris van Dalen, Sander Kooijman, Freek J. Janssen, Patrick C.N. Rensen, Daisuke Ogasawara, Benjamin F. Cravatt, Mario van der Stelt
Publikováno v:
Journal of Medicinal Chemistry, 60, 428-440
Journal of Medicinal Chemistry, 60, 1, pp. 428-440
Journal of Medicinal Chemistry, 60(1), 428-440
Journal of Medicinal Chemistry, 60, 1, pp. 428-440
Journal of Medicinal Chemistry, 60(1), 428-440
Contains fulltext : 181821.pdf (Publisher’s version ) (Closed access) Triazole ureas constitute a versatile class of irreversible inhibitors that target serine hydrolases in both cells and animal models. We have previously reported that triazole ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f05fa960c423196b9ee50434b9e5c5
https://doi.org/10.1021/acs.jmedchem.6b01482
https://doi.org/10.1021/acs.jmedchem.6b01482