Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Clinical Cancer Research. 11:7607-7613
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) is mediated through the activation of apoptosis signal–regulating kinase 1 (ASK1) as a
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Biochemical Journal. 373:845-853
Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation. Glucose deprivation disrupted the interaction between TRX/GRX and ASK1 and subsequently activate
Autor:
Yong J. Lee, Jae J. Song
Publikováno v:
Journal of Cellular Biochemistry. 89:653-662
Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinical
Publikováno v:
Molecular Pharmacology. 62:1409-1417
We observed previously that glucose deprivation induces cytotoxicity, increases the intracellular levels of hydroperoxide, and activates the stress-activated protein kinase (SEK) pathway. In this study, we hypothesized that 1-methylpropyl 2-imidazoly
Autor:
So Y. Kim, Bo K. Sun, Sujin Choi, Jae J. Song, Hoan N. Nguyen, Hye Jin Choi, Seeun Oh, Yong J. Lee, Joo Hang Kim
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to activate mitogen-activated protein kinases (MAPKs) depending on caspase and mammalian sterile 20-like kinase 1 activations. However, the upstream molecule of MAPKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c65566c90effa191f4b761bc0419ee
https://europepmc.org/articles/PMC3041593/
https://europepmc.org/articles/PMC3041593/
Publikováno v:
The Journal of biological chemistry. 280(49)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selective in the induction of apoptosis in cancer cells with minimal toxicity to normal tissues. However, not all cancers are sensitive to TRAIL-mediated apoptosis.
Autor:
Jae J, Song, Yong J, Lee
Publikováno v:
The Journal of Cell Biology
We have previously observed that metabolic oxidative stress-induced death domain-associated protein (Daxx) trafficking is mediated by the ASK1-SEK1-JNK1-HIPK1 signal transduction pathway. The relocalized Daxx from the nucleus to the cytoplasm during
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of cellular biochemistry. 92(6)
Death-associated protein (Daxx) deletion mutant (aa 501–625) has been known to be an inducer of apoptosis. In this study, we observed that the Bax-dependent mitochondrial death signaling pathway plays an important role in Daxx501–625-induced apop
Publikováno v:
Experimental cell research. 293(1)
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL/APO-2L), a member of the tumor necrosis factor (TNF) gene family, is considered as one of the most promising cancer therapeutic agents due to its ability to selectively kill tumor cells.