Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ansuman T. Satpathy"'
Autor:
Kenneth M. Murphy, Gary E. Grajales-Reyes, Rodney D. Newberry, Carlos G. Briseño, Prachi Bagadia, Howard Y. Chang, Theresa L. Murphy, Vivek Durai, Swapneel J. Patel, Xiao Huang, Hiromi Tagoh, Jeffrey M. Granja, Miriam Wöhner, Jesse T. Davidson, Barbara L. Kee, Ansuman T. Satpathy, Tian Tian Liu, Renee Wu, Meinrad Busslinger, Arifumi Iwata, Devesha H. Kulkarni
Publikováno v:
Nature immunology
Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 e
Autor:
Leif S. Ludwig, Rany M. Salem, Jacob C. Ulirsch, Joel N. Hirschhorn, Ansuman T. Satpathy, Caleb A. Lareau, Erik L. Bao, Michael H. Guo, Christian Benner, Jason D. Buenrostro, Vijay G. Sankaran, Hilary K. Finucane, Martin J. Aryee, Vinay K. Kartha
Publikováno v:
Nature Genetics. 51:683-693
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation represent substantial challenges to elucidating mechanisms of trait-associated genetic variation. Here we perform genetic fine-mapping for blood cell traits i
Autor:
Mark Y. Jeng, Ansuman T. Satpathy, Howard Y. Chang, Maxwell R. Mumbach, Anne Lynn S. Chang, Jeffrey M. Granja
Publikováno v:
Journal of Investigative Dermatology. 139:605-614
The vast majority of polymorphisms for human dermatologic diseases fall in noncoding DNA regions, leading to difficulty interpreting their functional significance. Recent work using chromosome conformation capture technology in combination with chrom
Autor:
Xiao Huang, Julia A. Belk, Yanyan Qi, Marco Colonna, Jing Chen, Nghi Ly, Changxu Fan, Ting Wang, Raki Sudan, Martin Guilliams, Pritesh Desai, Prachi Bagadia, Ansuman T. Satpathy, Stephen T. Ferris, Theresa L. Murphy, Mayank N. K. Choudhary, Yu Xia, Takeshi Egawa, Michael S. Diamond, Kenneth M. Murphy, Sunkyung Kim, Tiantian Liu, Quanming Shi
Publikováno v:
Immunity
The transcriptional repressor ZEB2 regulates development of many cell fates among somatic, neural and hematopoietic lineages, but the basis for its requirement in these diverse lineages is unclear. Here, we identified a 400 basepair (bp) region locat
Autor:
Robert Schöpflin, Vineet Bafna, Liangqi Xie, Konstantin Helmsauer, M. Ryan Corces, Natasha E. Weiser, Zhe Liu, Anton G. Henssen, Anindya Bagchi, Howard Y. Chang, Utkrisht Rajkumar, Rui Li, Katerina Kraft, Kathryn E. Yost, Robert Tjian, Sihan Wu, Julia A. Belk, Jens Luebeck, Siavash R. Dehkordi, King L. Hung, Celine Chen, Paul S. Mischel, Ivy Tsz-Lo Wong, Jun Tang, Jordan Friedlein, Stefan Mundlos, Quanming Shi, Joshua T. Lange, Rocío Chamorro González, Connor V. Duffy, John C. Rose, M. E. Valieva, Jeffrey M. Granja, Ansuman T. Satpathy
Publikováno v:
Nature
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation1. Gene induction typically involves cis-regulatory elements that contact and activate genes on
Publikováno v:
Nat Immunol
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation and function of innate and ad
Autor:
Theresa L. Murphy, Howard Y. Chang, Gary E. Grajales-Reyes, Zora Modrusan, Vivek Durai, Maximilian Nitschké, Jeffrey M. Granja, Xiao Huang, Carlos G. Briseño, Ansuman T. Satpathy, Marco Gargaro, Tiantian Liu, Kenneth M. Murphy, Arifumi Iwata, Sunkyung Kim, Andrey S. Shaw, Prachi Bagadia
Publikováno v:
Nature immunology
Classical type 1 dendritic cells (cDC1s) are required for antiviral and antitumor immunity, which necessitates an understanding of their development. Development of the cDC1 progenitor requires an E-protein-dependent enhancer located 41 kilobases dow
Autor:
Maxwell R. Mumbach, Nicki Naddaf, Theodore L. Roth, Nicolas Bray, Ruize Liu, Chun Jimmie Ye, K. Mark Ansel, Graham J. Ray, Mark S. Anderson, Dmytro Lituiev, Benjamin G. Gowen, Zhongmei Li, Therese Mitros, John D. Gagnon, Kyle Kai-How Farh, Hong Ma, Jacob E. Corn, Eric Boyer, Hailiang Huang, Youjin Lee, William J. Greenleaf, Rachel E. Gate, Victoria Tobin, Julia S. Chu, Meena Subramaniam, Ansuman T. Satpathy, Kathrin Schumann, Gemma L. Curie, Alexander Marson, Alice Y. Chan, Jonathan M. Woo, Mandy Boontanrart, Mark J. Daly, Michelle L.T. Nguyen, Frédéric Van Gool, Dimitre R. Simeonov, Howard Y. Chang, Jeffrey A. Bluestone
Publikováno v:
Nature. 559(7715)
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues1–3. Systematic mapping of functional enhancers a
Autor:
Thomas Quertermous, Josh Tycko, Paul A. Khavari, Ryan A. Flynn, Howard Y. Chang, Michelle L.T. Nguyen, Yuning Wei, Evan A. Boyle, Katelynn R. Kazane, Seung Woo Cho, Ansuman T. Satpathy, Dimitre R. Simeonov, Maxwell R. Mumbach, Rui Li, Jin Xu, Anshul Kundaje, Adam J. Rubin, Chao Dai, Peyton Greenside, Jacob E. Corn, William J. Greenleaf, Benjamin G. Gowen, M. Ryan Corces, Jeffrey M. Granja, Nabeela Suliman, Alexander Marson, Trieu Nguyen
The challenge of linking intergenic mutations to target genes has limited molecular understanding of human diseases. Here we show that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfaad27a20eee823400d5bb751eacf1
https://europepmc.org/articles/PMC5805393/
https://europepmc.org/articles/PMC5805393/
Autor:
Ansuman T. Satpathy, K. Mark Ansel, Nicolas Bray, Jeffrey A. Bluestone, Alice Y. Chan, Graham J. Ray, Dimitre R. Simeonov, Kyle Kai-How Farh, Theodore L. Roth, Zhongmei Li, Michelle L.T. Nguyen, Mark J. Daly, William J. Greenleaf, Kathrin Schumann, Gemma L. Curie, Mark S. Anderson, Ruize Liu, Chun Jimmie Ye, Howard Y. Chang, Alexander Marson, Dmytro Lituiev, Therese Mitros, Nicki Naddaf, Jacob E. Corn, Victoria Tobin, Meena Subramaniam, Maxwell R. Mumbach, Hailiang Huang, Benjamin G. Gowen, Rachel E. Gate, Julia S. Chu, John D. Gagnon, Hong Ma, Frédéric Van Gool, Youjin Lee, Eric Boyer, Jonathan M. Woo, Mandy Boontanrart
Publikováno v:
Nature, vol 549, iss 7670
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues. Systematic mapping of functional enhancers and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bd4330f085a76ad425b15ed30679cd
https://escholarship.org/uc/item/89t84794
https://escholarship.org/uc/item/89t84794