Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jan Trnka"'
Autor:
Michal Zuzčák, Jan Trnka
Publikováno v:
International Journal of Oncology. 61
Pancreatic cancer (PC) has one of the highest fatality rates and the currently available therapeutic options are not sufficient to improve its overall poor prognosis. In addition to insufficient effectiveness of anticancer treatments, the lack of cle
Autor:
Michal Anděl, Tomáš Urban, G. Hege Thoresen, Petr Waldauf, František Duška, Nils Gunnar Løvsletten, Vladimír Frič, Jan Trnka, Adéla Krajčová, Moustafa Elkalaf
Publikováno v:
Critical care medicine. 46(3)
Objectives Propofol may adversely affect the function of mitochondria and the clinical features of propofol infusion syndrome suggest that this may be linked to propofol-related bioenergetic failure. We aimed to assess the effect of therapeutic propo
Autor:
Jakub Ziak, Moustafa Elkalaf, V Dzupa, Jana Pátková, Katerina Jiroutkova, Jan Trnka, František Duška, Adéla Krajčová
Publikováno v:
Journal of Parenteral and Enteral Nutrition. 39:180-189
Glutamine has been considered essential for rapidly dividing cells, but its effect on mitochondrial function is unknown.Human myoblasts were isolated from skeletal muscle biopsy samples (n = 9) and exposed for 20 days to 6 different glutamine concent
Autor:
Kateřina Jiroutková, Jan Gojda, Adéla Krajčová, Jakub Žiak, Martin Kalous, Jan Trnka, František Duška, Michal Fric, Valér Džupa, Jana Tůmová
Publikováno v:
JPEN. Journal of parenteral and enteral nutrition. 41(7)
BACKGROUND Functional mitochondria in skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness are depleted, but remaining mitochondria have increased functional capacities of respiratory complexes II and
Autor:
Kateřina Jiroutková, Adéla Krajčová, Moustafa Elkalaf, František Duška, Jan Trnka, Petr Waldauf, Valér Džupa, Jakub Ziak, Vlasta Němcová-Fürstová, Jan Kovář, Michal Fric, Jan Gojda
Publikováno v:
Critical Care
Background Mitochondrial damage occurs in the acute phase of critical illness, followed by activation of mitochondrial biogenesis in survivors. It has been hypothesized that bioenergetics failure of skeletal muscle may contribute to the development o
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e70772 (2013)
PLoS ONE, Vol 8, Iss 8, p e70772 (2013)
BACKGROUND: Substituting galactose for glucose in cell culture media has been suggested to enhance mitochondrial metabolism in a variety of cell lines. We studied the effects of carbohydrate availability on growth, differentiation and metabolism of C
Publikováno v:
ResearcherID
Obesity is often associated with metabolic impairments in peripheral tissues. Evidence suggests an excess of free fatty acids (FFA) as one factor linking obesity and related pathological conditions and the impact of FFA overload on skeletal muscle me
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