Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Denise D. Belsham"'
Publikováno v:
Genes, Vol 14, Iss 9, p 1773 (2023)
The hypothalamus is a vital regulator of energy homeostasis. Orexigenic neuropeptide Y (NPY) neurons within the hypothalamus can stimulate feeding and suppress energy expenditure, and dysregulation of these neurons may contribute to obesity. We previ
Externí odkaz:
https://doaj.org/article/7be3e40697214597be8b55392be2b04a
Publikováno v:
Cells, Vol 10, Iss 11, p 3120 (2021)
The hypothalamus maintains whole-body homeostasis by integrating information from circulating hormones, nutrients and signaling molecules. Distinct neuronal subpopulations that express and secrete unique neuropeptides execute the individual functions
Externí odkaz:
https://doaj.org/article/8b318e48496a4c43b8fda1c57a3de04a
Publikováno v:
Molecular and cellular endocrinology. 539
Bisphenol A (BPA) is an endocrine disrupting chemical that promotes obesity. It acts on the hypothalamus by increasing expression of the orexigenic neuropeptides, Npy and Agrp. Exactly how BPA dysregulates energy homeostasis is not completely clear.
Publikováno v:
Molecular and Cellular Endocrinology. 479:12-19
Endocrine disrupting chemicals, such as bisphenol A (BPA), have been linked to obesity. However, the direct effect of BPA on the hypothalamic pro-opiomelanocortin (POMC) neurons, which regulate energy homeostasis, remains unexplored. We define the ef
Publikováno v:
Pharmacology & Therapeutics. 233:108033
Spexin is the most recently discovered member of the galanin/kisspeptin/spexin family of peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic functions including, but not limited to, metabolism, energy homeostasis
The hypothalamus is a vital and an integral part of the central nervous system as it regulates a wide range of physiological and psychological processes, including energy homeostasis, reproduction, circadian rhythms, as well as emotional and behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c31d1d72adbf2b81797a7f2e0764ac78
https://doi.org/10.1016/b978-0-12-819801-8.00002-8
https://doi.org/10.1016/b978-0-12-819801-8.00002-8
Autor:
Beatriz Piatezzi Siqueira, Letícia Martins Ignácio-Souza, Andressa Reginato, Adriana Souza Torsoni, Marcio Alberto Torsoni, Marciane Milanski, Mariana Portovedo, Hosana G. Rodrigues, Denise D. Belsham, Suleyma O. Costa, Hervé Le Stunff, Thaís de Fante, Josiane Érica Miyamoto
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 32(10)
High-fat diet (HFD) feeding is deleterious to hypothalamic tissue, leading to inflammation and lipotoxicity, as well as contributing to central insulin resistance. Autophagy is a process that restores cellular homeostasis by degrading malfunctioning
Publikováno v:
Molecular and Cellular Endocrinology. 438:18-26
Diet-induced obesity can lead to detrimental chronic disorders. The severity of this global epidemic has encouraged ongoing research to characterize the mechanisms underlying obesity and its comorbidities. Recent evidence suggests that saturated fatt
Autor:
William Brett McIntyre, Margaret Hahn, Denise D. Belsham, Pruntha Kanagasundaram, Chantel Kowalchuk
Publikováno v:
Psychoneuroendocrinology. 109:104400
Introduction Second-generation antipsychotics cause serious metabolic side effects, but the mechanisms behind these effects remain largely unknown. However, emerging evidence supports that antipsychotics may act upon the hypothalamus, the primary bra
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 315(2)
The brain, specifically the hypothalamus, controls whole body energy and glucose homeostasis through neurons that synthesize specific neuropeptides, whereas hypothalamic dysfunction is linked directly to insulin resistance, obesity, and type 2 diabet