Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Zhi-Hua Zhang"'
Autor:
Wei-Liang Liu, Li Shi, Yi-Cheng Wang, Rui-Min Yang, Xue-Liang Wu, Zhi-Hua Zhang, Zhen-Shun Hu, Li-Kun Wang
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 6:41-49
Diabetes remains a long standing public health issue among the Chinese population, with an incidence of up to 11.6%, of which type 2 diabetes mellitus (T2DM) accounts for 85%–95%. During this study, we aimed to elucidate the value of high-frequency
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H732-H739
Brain MAPK signaling pathways are activated in heart failure (HF) induced by myocardial infarction and contribute to augmented sympathetic nerve activity. We tested whether decreasing ERK1/2 (also known as p44/42 MAPK) signaling in the hypothalamic p
Publikováno v:
Hypertension. 65:1126-1133
Our previous work indicated that the subfornical organ (SFO) is an important brain sensor of blood-borne proinflammatory cytokines, mediating their central effects on autonomic and cardiovascular function. However, the mechanisms by which SFO mediate
Autor:
Alan Kim Johnson, Robert B. Felder, Zhi-Hua Zhang, Fang Guo, Yang Yu, Terry G. Beltz, Baojian Xue, Shun-Guang Wei
Publikováno v:
Hypertension. 61:842-849
Blood-borne angiotensin II (ANG II) can upregulate p44/42 mitogen-activated protein kinase (MAPK) signaling and ANG II type-1 receptors in the hypothalamic paraventricular nucleus (PVN), a critical cardiovascular and autonomic center. We tested the h
Publikováno v:
Hypertension. 59:991-998
The ample expression of chemokines and their receptors by neurons in the brain suggests that they play a functional role beyond the coordination of inflammatory and immune responses. Growing evidence implicates brain chemokines in the regulation of n
Publikováno v:
Hypertension. 59:477-484
Activation of peroxisome proliferator-activated receptor (PPAR)-γ, a nuclear transcription factor, has been shown to inhibit the production of proinflammatory cytokines and, in peripheral tissues, to downregulate the renin-angiotensin system. PPAR-
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2015 (2015)
Oxidative Medicine and Cellular Longevity, Vol 2015 (2015)
Our evidence demonstrated that CKD upregulated the expression of myostatin, TNF-α, and p-IkBa and downregulated the phosphorylation of PI3K, Akt, and FoxO3a, which were also associated with protein degradation and muscle atrophy. The autophagosome f
Autor:
Zhi-Hua Zhang, Kazuhiro Nakamura, Yoshiko Nakamura, Shun-Guang Wei, Robert B. Felder, Yang Yu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H1559-H1569
Prostaglandin E2 (PGE2), an important mediator of the inflammatory response, acts centrally to elicit sympathetic excitation. PGE2 acts on at least four E-class prostanoid (EP) receptors known as EP1, EP2, EP3, and EP4. Since PGE2 production within t
Publikováno v:
Journal of Hypertension. 28:806-816
OBJECTIVE The mechanisms by which inflammation activates sympathetic drive in heart failure and hypertension remain ill-defined. In this study, an intracerebroventricular injection of lipopolysaccharide (LPS) was used to induce the expression of cyto
Publikováno v:
Hypertension. 55:652-659
Inflammation is associated with increased sympathetic drive in cardiovascular diseases. Blood-borne proinflammatory cytokines, markers of inflammation, induce cyclooxygenase 2 (COX-2) activity in perivascular macrophages of the blood-brain barrier. C