Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Vergil"'
Autor:
Roger P. Smith, Vergil H. Ferm, Dean E. Wilcox, Harriet Kruszyna, Theodore R. Sana, Robert Kruszyna
Publikováno v:
Fundamental and Applied Toxicology. 15:754-759
Pairs of osmotic minipumps containing 400 mg/ml (6.15 m ) sodium azide in distilled water were subcutaneously implanted in timed pregnancy Syrian golden hamsters. The total delivered dose was calculated as 6 × 10 −2 mmol kg −1 hr −1 at the max
Publikováno v:
Reproductive Toxicology. 4:183-190
Pregnant hamsters were treated with selenite, selenate, and selenomethionine during the critical stages of embryogenesis. The dosing regimens were oral, intravenous, and osmotic minipump infusion. Malformations, mainly encephaloceles, were noted with
Publikováno v:
Teratology. 42(4)
Inorganic selenium (Se) salts (selenite and selenate oxyanions) and the organic selenoamino acids (selenomethionine and seleniferous grains) are teratogenic and embryolethal in domestic and wild birds. Selenium bioaccumulation has been held responsib
Publikováno v:
Reproduction. 44:109-112
Manganese is an essential trace element in the living system. It is invariably present in its ionic form and is known to participate in a number of biological systems (Cotzias, 1958). Relatively high levels of manganese are required to manifest toxic
Publikováno v:
Fundamental and Applied Toxicology. 3:41-48
Succinonitrile (SN) and tetramethylsuccinonitrile (TMSN) were evaluated and compared for their teratogenic potential. Groups of 3 to 20 pregnant hamsters received a single ip injection of either SN, at doses ranging from 0.78 to 6.24 mmol/kg, or TMSN
Autor:
David P. Hanlon, Vergil H. Ferm
Publikováno v:
Teratology. 34:189-193
Hamster dams dosed continuously with arsenate and exposed to short-term hyperthermia produced a greater percentage of malformed offspring than did hamster dams dosed with arsenate alone. Hamsters receiving both treatments possessed elevated arsenic c
Publikováno v:
Fundamental and Applied Toxicology. 4:977-982
Etretinate (Ro 10-9359; Tigason; 4-methoxy-2,3,6-trimethylphenyl analog of retinoic acid, ethyl ester) was evaluated for teratogenic activity in the Syrian golden hamster, Groups of pregnant hamsters were given a single oral dose of 2.8–88 mg/kg et
Autor:
D. P. Hanlon, Vergil H. Ferm
Publikováno v:
Experientia. 45:767-770
A normally teratogenic dose of cadmium ions administered to hamsters late in gestation does not cross the placental barrier nor does it result in placental pathology. Our finding, which differs from data for other rodents, may be due to differences i
Autor:
Vergil H. Ferm, Joseph V. Rutkowski
Publikováno v:
Toxicology and Applied Pharmacology. 63:264-269
para -Aminophenol ( p -AP), recently demonstrated to be a metabolic product of the analgesic-antipyretic agent, acetaminophen, was evaluated for teratogenicity. Also included for evaluation were the other isomeric forms of aminophenol, meta and ortho
Autor:
Vergil H. Ferm, W. M. Layton
Publikováno v:
Teratology. 21:357-360
Administration of 12 μmol/kg of cadmium sulfate ip to C57BL/6J mice within 3 weeks prior to pregnancy significantly reduced the incidence of limb malformations induced by 6 μrnol/kg of cadmium sulfate given ip on day 9 of pregnancy. In another expe