Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samuel K. Handelman"'
Autor:
Rishel B Vohnoutka, Annapurna Kuppa, Yash Hegde, Yue Chen, Asmita Pant, Maurice E Tohme, Eun-Young (Karen) Choi, Sean M McCarty, Devika P Bagchi, Xiaomeng Du, Yanhua Chen, Vincent L Chen, Hiroyuki Mori, Lawrence F Bielak, Lillias H Maguire, Samuel K Handelman, Jonathan Z Sexton, Thomas L Saunders, Brian D Halligan, Elizabeth K Speliotes
Publikováno v:
Journal of Molecular Endocrinology. 70
Human genome-wide association studies found single-nucleotide polymorphisms (SNPs) near LYPLAL1 (Lysophospholipase-like protein 1) that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLAL1 affects
Autor:
Eun-Young Choi, Yanhua Chen, Asmita Pant, Annapurna Kuppa, Jonathan Z. Sexton, Lillias H. Maguire, Thomas L. Saunders, Samuel K. Handelman, Devika P. Bagchi, Elizabeth K. Speliotes, Lawrence F. Bielak, Yue Chen, Sean M McCarty, Rishel B. Vohnoutka, Xiaomeng Du, Brian D. Halligan, Vincent L. Chen, Yash Hegde
Human genome-wide association studies found SNPs near LYPLAL1 that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLAL1 affects obesity and metabolic disease we created and characterized a mouse kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6221f8d37a11b2b18d58c7dd95f3c84
https://doi.org/10.1101/2021.08.05.455257
https://doi.org/10.1101/2021.08.05.455257
Autor:
Elizabeth K. Speliotes, Yue Chen, James G. Terry, Adolfo Correa, Bratati Kahali, Yii-Der Ida Chen, Vilmundur Gudnason, Yanhua Chen, Jeffrey R. O'Connell, Brian D. Halligan, Tamara B. Harris, Matthew A. Allison, Thomas H. Mosley, Xiuqing Guo, Matthew J. Budoff, Donald W. Bowden, J. Jeffrey Carr, Lenore J. Launer, Sharon L.R. Kardia, Kathleen A. Ryan, Jian Yang, Xiaomeng Du, Samuel K. Handelman, Breland F. Crudup, Laura M. Yerges-Armstrong, Lawrence F. Bielak, Yash Hegde, Shannon Carskadon, Ariella Cohain, Nicholette D. Palmer, Gudny Eiriksdottir, Solomon K. Musani, Eric E. Schadt, Nallasivam Palanisamy, Lynne E. Wagenknecht, Michael A. Province, Yi-Ping Fu, Christopher J. O'Donnell, Patricia A. Peyser, Albert V. Smith, Mary F. Feitosa, Jerome I. Rotter, Jiankang Liu, Andrew Bakshi, Lindsay Stetson, Jill M. Norris
Publikováno v:
J Clin Endocrinol Metab
Context Glycogen storage diseases are rare. Increased glycogen in the liver results in increased attenuation. Objective Investigate the association and function of a noncoding region associated with liver attenuation but not histologic nonalcoholic f
Autor:
Xiuqing Guo, Matthew J. Budoff, Lawrence F. Bielak, Abigail S. Baldridge, Elizabeth K. Speliotes, J. Jeffrey Carr, Thomas H. Mosley, Mary F. Feitosa, Lenore J. Launer, Sharon L.R. Kardia, Myriam Fornage, Albert V. Smith, Laura J. Rasmussen-Torvik, Yii-Der Ida Chen, Vilmundur Gudnason, Laura M. Yerges-Armstrong, Kathleen A. Ryan, Jerome I. Rotter, Tamara B. Harris, Matthew A. Allison, Ingrid B. Borecki, Brian D. Halligan, Samuel K. Handelman, Jie Yao, Lisa B. VanWagner, Patricia A. Peyser, Llilda Barata, Michael A. Province, Nicholette D. Palmer, Jeffrey R. O'Connell
Publikováno v:
Hepatology Communications
Hepatology communications, vol 3, iss 7
Hepatology Communications, Vol 3, Iss 7, Pp 894-907 (2019)
Hepatology communications, vol 3, iss 7
Hepatology Communications, Vol 3, Iss 7, Pp 894-907 (2019)
The accumulation of excess fat in the liver (hepatic steatosis) in the absence of heavy alcohol consumption causes nonalcoholic fatty liver disease (NAFLD), which has become a global epidemic. Identifying metabolic risk factors that interact with the
Publikováno v:
Gastroenterology. 158:S-1272
Autor:
Philip M. Brown, Olga V. Belyaeva, Cara Nestlerode, Natalia Y. Kedishvili, Katherine Valles, Yaron Rotman, Arun J. Sanyal, Yanhua Chen, Emmanuel Thomas, Yanling Ma, Vincent L. Chen, Ynto S. de Boer, Elizabeth K. Speliotes, Suman Karki, Joseph M. Zmuda, Christopher Koh, Xiaomeng Du, Koji Fujita, Samuel K. Handelman, David E. Kleiner, T. Jake Liang
Publikováno v:
Hepatology (Baltimore, Md.). 69(4)
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A single nucleotide polymorphism (SNPs), rs6834314, was associated with serum liver enzymes in the general population, presumably reflecting liver fat or injury. We
Autor:
Rebecca D. Jackson, Jing Nie, Rami Nassir, Leah Preus, Kathleen M. Hovey, Lara E. Sucheston-Campbell, Youjin Wang, Samuel K. Handelman, Heather M. Ochs-Balcom, Jean Wactawski-Wende, Carolyn J. Crandall
Publikováno v:
The Journal of clinical endocrinology and metabolism. 102(6)
Context Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored. Objective The objective was to test an in
Autor:
Rebecca D. Jackson, Aaron K. Aragaki, Charles Kooperberg, Peter P. Pramstaller, Emelia J. Benjamin, Samuel K. Handelman, Joel Eriksson, Aude Saint-Pierre, Johnny S. H. Kwan, Yi-Hsiang Hsu, Daniel Taliun, Irene Pichler, Ching-Lung Cheung, Martin G. Larson, Claes Ohlsson, Pak C. Sham, Andrea Z. LaCroix, Douglas P. Kiel, Josée Dupuis, Annie W.C. Kung, KS Lau, Mattias Lorentzon, David Karasik, Andrew A. Hicks, Liesbeth Vandenput
Publikováno v:
Kwan, Johnny SH; Hsu, Yi-Hsiang; Cheung, Ching-Lung; Dupuis, Josée; Saint-Pierre, Aude; Eriksson, Joel; et al.(2014). Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.. Human molecular genetics, 23(24), 6684-6693. doi: 10.1093/hmg/ddu386. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/86t7v4xc
Human molecular genetics, vol 23, iss 24
Human molecular genetics, vol 23, iss 24
Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedebbf13a6cfb81585657a8ee6e69e8
http://www.escholarship.org/uc/item/86t7v4xc
http://www.escholarship.org/uc/item/86t7v4xc