Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Joseph Bass"'
Autor:
Yuanchao Ye, Marwa Abu El Haija, Reine Obeid, Hussein Herz, Liping Tian, Benjamin Linden, Yi Chu, Deng Fu Guo, Daniel C. Levine, Jonathan Cedernaes, Kamal Rahmouni, Joseph Bass, Mohamad Mokadem
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
The molecular clock machinery regulates several homeostatic rhythms, including glucose metabolism. We previously demonstrated that Roux-en-Y gastric bypass (RYGB) has a weight-independent effect on glucose homeostasis and transiently reduces food int
Externí odkaz:
https://doaj.org/article/c85266c72aed4208b90efdcdf61f2ca5
Autor:
Haitham Abdulla, Bethan Phillips, Daniel Wilkinson, Amanda Gates, Marie Limb, Tereza Jandova, Joseph Bass, Johnathan Lewis, John Williams, Kenneth Smith, Iskandar Idris, Philip Atherton
Publikováno v:
The Journal of clinical endocrinology and metabolism.
Introduction Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypoth
Autor:
Elizabeth M. McNally, Nancy L. Kuntz, Alexis R. Demonbreun, Mattia Quattrocelli, Zhen Jiang, Clara Bien Peek, Saptarsi M. Haldar, Aaron S. Zelikovich, Joseph Bass, Grant D. Barish
Publikováno v:
JCI Insight. 4
In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the side effects seen with d
Autor:
Alexander R Mackie, Asish K. Ghosh, So Youn Kim, Joseph Bass, Daniele Procissi, Rahul Rai, Jonathan Cedernaes, Veronica Ramirez, Teresa K. Woodruff, Layton H. Smith, Mesut Eren, Daniel C. Levine, Douglas E. Vaughan
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1471-1480 (2017)
Summary: Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD). Recent studies indicate that blood from young mice reduces age-associated pathologies. However, the “anti-aging” factors in juvenile circulation re
Autor:
Roland Stein, Mark Perelis, Joseph Bass, Holly A. Cyphert, Shuangli Guo, Yu-Ping Yang, Jin Hua Liu, Mark A. Magnuson, Christopher V.E. Wright, Jason M. Spaeth, Min Guo, Manisha Gupte
Publikováno v:
Diabetes. 66:2830-2839
The transcription factor encoded by the Pdx1 gene is a critical transcriptional regulator, as it has fundamental actions in the formation of all pancreatic cell types, islet β-cell development, and adult islet β-cell function. Transgenic- and cell
Publikováno v:
Diabetes, Obesity and Metabolism. 17:99-105
Circadian clocks are biologic oscillators present in all photosensitive species that produce 24-hour cycles in the transcription of rate-limiting metabolic enzymes in anticipation of the light-dark cycle. In mammals, the clock drives energetic cycles
Autor:
Raj Awatramani, Daniel C. Levine, Biliana Marcheva, Xiaozhong Wang, Nathan Waldeck, Mohamad Mokadem, Joseph S. Takahashi, Joseph Bass, Ravindra Dhir, Clara Bien Peek, Wenyu Huang, Rexford S. Ahima, Yumiko Kobayashi, Lei Cheng, Jonathan Cedernaes, Kathryn Moynihan Ramsey, Chiaki Omura, Christopher A. Bradfield
Publikováno v:
Cell Metab
The alignment of fasting and feeding with the sleep/ wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eatin
Autor:
Ying Li, Joseph Bass, Alfonso Abizaid, Tamas L. Horvath, Marcelo O. Dietrich, Joseph S. Takahashi
Publikováno v:
Molecular Metabolism. 1(1-2):79-85
Ghrelin, a circulating gut-hormone, has emerged as an important regulator of growth hormone release and appetite. Ghrelin-immunopositive neurons have also been identified in the hypothalamus with a unique anatomical distribution. Here, we report that
Publikováno v:
J Biol Rhythms
The mammalian circadian clock plays a central role in the temporal coordination of physiology across the 24-h light-dark cycle. A major function of the clock is to maintain energy constancy in anticipation of alternating periods of fasting and feedin
Autor:
Jonathan Cedernaes, Joseph Bass
Publikováno v:
eLife, Vol 5 (2016)
Neurons in the brainstem are the input for a neural circuit that integrates nutrient signals to control feeding behavior.