Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jianhai Du"'
Autor:
Elizabeth Gregor, Siyan Zhu, Fanyi Zhong, Allison Grenell, Yekai Wang, Daniel Lohner, Jianhai Du, Jiangjiang Zhu, Michelle Yam, Allison Hauer
Publikováno v:
Neurobiology of Aging. 71:223-233
Aging is a major risk factor for age-related ocular diseases including age-related macular degeneration in the retina and retinal pigment epithelium (RPE), cataracts in the lens, glaucoma in the optic nerve, and dry eye syndrome in the cornea. We use
Autor:
Michael J. Jurczak, Nikolas Dedousis, Eugenia Cifuentes-Pagano, Eckels Jt, Eric E. Kelley, Mandler Wk, Jianhai Du, Patrick J. Pagano, Robert M. O'Doherty, Maja Stefanovic-Racic, Brydie R. Huckestein, Daniel B. Harmon, Gregg E. Homanics, Van't Erve Tj, Yekai Wang, Ian Sipula, Sara E. Lewis
Publikováno v:
Diabetes
Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistan
Autor:
Xigang Jing, David M. Gourlay, Yang Shi, Weiling Wang, Deron W. Jones, Kirkwood A. Pritchard, Dorothee Weihrauch, Hao Zhang, Tongju Guan, Cheryl A. Hillery, Jianhai Du, Keith T. Oldham, Hao Xu
Publikováno v:
Journal of Lipid Research. 54:3016-3029
Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits
Autor:
Shelley L. Baumgardt, David C. Warltier, Zhi-Dong Ge, Jianhai Du, Shigang Qiao, Yanan Liu, Juan Fang, Zeljko J. Bosnjak, Judy R. Kersten, Hsiang En Wu, Yang Shi, Mark Paterson
Publikováno v:
Scientific Reports
Diabetic cardiomyopathy increases the risk of heart failure and death. At present, there are no effective approaches to preventing its development in the clinic. Here we report that reduction of cardiac GTP cyclohydrolase 1 (GCH1) degradation by gene
Publikováno v:
British Journal of Pharmacology. 166:676-688
BACKGROUND AND PURPOSE IL-6 plays crucial roles in cardiac hypertrophy, cardiac fibrosis and heart failure. Activation of β-adrenoceptors induced IL-6 production in neonatal mouse cardiac fibroblasts (NMCFs) through a G(s) /adenylate cyclase/cAMP/p3
Publikováno v:
Shock. 37:325-332
Recently, we reported that Brown Norway (BN) rats were more resistant to lipopolysaccharide (LPS)-induced myocardial dysfunction than Dahl S (SS) rats. This differential sensitivity was exemplified by reduced production of proinflammatory cytokines a
Autor:
Jianhai Du, Zhi-Dong Ge, David C. Warltier, Anna K. Brzezinska, Thorsten M. Leucker, Nikolina Vladic, Phillip F. Pratt, Yang Shi, Judy R. Kersten
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H2130-H2139
Cardioprotection by ischemic preconditioning (IPC) is impaired during hyperglycemia, but the mechanisms underlying this phenomenon are poorly understood. This study investigated the role of hyperglycemia to adversely modulate tetrahydrobiopterin (BH4
Publikováno v:
Shock. 33:332-336
We previously demonstrated that hearts from Brown Norway (BN) rats were more resistant to ischemic injury than hearts from Dahl S (SS) rats. Here we determined the susceptibility to LPS-induced cardiomyopathy in these rats and examined the involvemen
Publikováno v:
Acta Pharmacologica Sinica. 28:153-165
Recently, there have been important advancements in our understanding of the signaling mechanisms of adrenoreceptors (AR) and signal transducers and activators of transcription 3 (STAT3). While their crucial roles in the pathological processes of the
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 304(1)
Pulmonary artery endothelial cells (PAEC) isolated from fetal lambs with in utero pulmonary hypertension (IPH) have phenotypical changes that lead to increased reactive oxygen species (ROS) formation and impaired angiogenesis. AMP-activated protein k