Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hideo Araki"'
Autor:
Ayumi Ando, Toshiya Tamura, Satoshi Kitazawa, Megumi Morimoto, Kohei Honda, Takahito Hara, Satoru Nishizawa, Kikuo Nutahara, Yoshinori Satomi, Takatsugu Okegawa, Hideo Araki
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 31-38 (2017)
EBioMedicine
EBioMedicine
Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation of the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated in kidney cancer. Howeve
Autor:
Hideo Araki, Shuichi Furuya, Masami Kusaka, Masataka Harada, Masahiko Fujino, Nobuhiro Suzuki, Nobuo Cho, Takahito Hara
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:1697-1704
TAK-013 is a novel nonpeptide and orally active GnRH antagonist. We first examined the effect of TAK-013 on GnRH-stimulated LH release using primary-cultured pituitary cells of cynomolgus monkeys. TAK-013 suppressed LH release to below basal levels a
Publikováno v:
Life Sciences. 68:1951-1963
Body temperature dependency in gastric functional responses to baclofen, a GABA B agonist, such as acid secretion, mucosal blood flow (GMBF) and motor activity, was examined in urethane-anesthetized rats under normal (37±1 °C) and hypothermic (31±
Publikováno v:
Journal of Physiology-Paris. 95:157-163
Gastrointestinal ulcerogenic effect of indomethacin is causally related with an endogenous prostaglandin (PG) deficiency, yet the detailed mechanism remains unknown. We examined the effect of various PGE analogues specific to EP receptor subtypes on
Autor:
Shoji Kawauchi, Hiroyuki Mizoguchi, Tomonori Kunikata, Koji Takeuchi, Hideo Araki, Kimihito Tashima
Publikováno v:
Journal of Gastroenterology and Hepatology. 15:37-45
The present article overviews the regulatory mechanism of acid secretion in the stomach after damage with taurocholate (TC), one of the bile acids. Mucosal exposure of a rat stomach to 20 mmol/L TC for 30 min caused a decrease of acid secretion with
Autor:
Koji Takeuchi, Hideo Araki, Shinichi Kato, Hideki Ukawa, Yukihiko Sugimoto, Shuh Narumiya, Osamu Furukawa, Fumitaka Ushikubi, Atsusi Ichikawa
Publikováno v:
Gastroenterology. 117:1128-1135
Background & Aims: To examine the involvement of EP 3 receptors in physiological regulation of duodenal HCO 3 − secretion, we disrupted the gene encoding EP receptors in mice by homologous recombination and evaluated acid-induced HCO 3 − secretio
Autor:
Hidekazu Nishiwaki, Osamu Furukawa, Hideo Araki, Masakazu Umeda, Koji Takeuchi, Akinobu Fujita
Publikováno v:
Life Sciences. 65:1207-1216
Gastric mucosal blood flow (GMBF) response and the recovery of gastric mucosal integrity were investigated in anesthetized rat stomachs after damage by monochloramine (NH2Cl), in comparison with 20 mM taurocholate Na (TC). A rat stomach was mounted i
Publikováno v:
Digestion. 63(2)
Backgrounds and Aims: We examined the effect of various prostaglandin E (PGE) analogs specific to EP receptor subtypes on indomethacin-induced gastric lesions in rats and investigated which EP receptor subtype is involved in the protective action of
Autor:
Masakazu Umdeda, Keizo Suzuki, Hiroyuki Mizoguchi, Hideo Araki, Koji Takeuchi, Shinichi Sugamoto
Publikováno v:
Journal of physiology, Paris. 93(5)
We examined the roles of endogenous prostaglandins (PGs) and nitric oxide (NO) in the gastroduodenal ulcerogenic responses to hypothermic stress (28∼30 °C) in anesthetized rats. Lowering body temperature provoked damage in the gastroduodenal mucos
Publikováno v:
European journal of applied physiology and occupational physiology. 69(1)
In the present study, we investigated whether weak (10% of maximal voluntary contraction) tonic dorsiflexion (DF) and plantarflexion (PF) affects the two conventional parameters used for evaluating the excitability of the soleus motoneuron (MN) pool,