Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Anna Mae Diehl, Ning-Ping Zhang, Ying Wang, Chen Yang, Xiuping Liu, Xue-Jing Liu, Wen‐Yue Dong, Chang Liu, Li Xie, Manal F. Abdelmalek, Jian Wu, Chenjian Gu, Kuo Du, Chen Niu
Publikováno v:
Liver Int
Background and aims Treatment of non-alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigat
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
Brian B. Graham, Anna Mae Diehl, Marzena Swiderska-Syn, Kristen Robbins, Zhaoxing Pan, Shikha S. Sundaram, Kelley E. Capocelli, Ronald J. Sokol, Ann C. Halbower
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 883-893 (2019)
Hepatology Communications
Hepatology Communications
Chronic intermittent hypoxia and hedgehog (Hh) pathway dysregulation are associated with nonalcoholic fatty liver disease (NAFLD) progression. In this study, we determined the relationship between obstructive sleep apnea (OSA)/nocturnal hypoxia and H
Autor:
Geoffrey I. Scott, Varun Chandrashekaran, Prakash S. Nagarkatti, Diana Kimono, Samir Raychoudhury, Mitzi Nagarkatti, Sutapa Sarkar, Anna Mae Diehl, Firas Alhasson, Ratanesh Seth, Saurabh Chatterjee, Muayad Albadrani, Diptadip Dattaroy
Publikováno v:
Redox Biology, Vol 17, Iss, Pp 1-15 (2018)
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E
Autor:
Bryan W. Brooks, Mitzi Nagarkatti, Samir Raychoudhury, Anna Mae Diehl, Sutapa Sarkar, Dwayne E. Porter, Geoff Scott, Diana Kimono, Muayad Albadrani, Saurabh Chatterjee, Yvon Jule, Dipro Bose, Ratanesh Seth, Ayan Mondal, Prakash S. Nagarkatti
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Nonalcoholic fatty liver disease (NAFLD) is an emerging global pandemic. Though significant progress has been made in unraveling the pathophysiology of the disease, the role of protein phosphatase 2A (PP2A) and its subsequent inhibition by environmen
Publikováno v:
Journal of Hepatology. 68:550-562
Liver disease remains a leading cause of mortality worldwide despite recent successes in the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling an epidemic of chronic fatty liver disease for which there are cu
Autor:
Rasha Younis, Zhiyong Mi, Anna Mae Diehl, Paul C. Kuo, Marzena Swiderska-Syn, Naoto Kitamura, D. Reid, Lee C. Claridge, Lars P. Bechmann, Kosha J. Mehta, Jason D. Coombes, Karine Gauthier, Paul Manka, G. Gerken, MA Briones, W.-K. Syn, F Flamant, Ali Canbay, Bertus Eksteen, Roger Williams
Publikováno v:
Zeitschrift für Gastroenterologie. 54:1343-1404
Thyroid hormone (TH) signaling is critical for tissue-organ development, growth, differentiation and metabolism, and in the liver, the most widely expressed TH receptor is TRβ. In a recent study of patients with nonalcoholic steatohepatitis (NASH),
Autor:
Gregory A. Michelotti, Mark L. Jewell, Marzena Swiderska-Syn, Richard T. Premont, Anna Mae Diehl, Guanhua Xie, Wing-Kin Syn
Publikováno v:
Hepatology. 64:232-244
Introduction: Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity t
Autor:
Ayako Suzuki, Cynthia D. Guy, Jagpal Singh Klair, Ju Dong Yang, Jeanne M. Clark, Katherine P. Yates, Anna Mae Diehl, Ryan M. Gill, Aynur Unalp-Arida, Manal F. Abdelmalek, Joel E. Lavine
Publikováno v:
Hepatology. 64:85-91
UNLABELLED Postmenopausal women with nonalcoholic steatohepatitis are at an increased risk of hepatic fibrosis compared with premenopausal women. Whether duration of estrogen deficiency in postmenopausal state dictates an individual's fibrosis risk r
Autor:
Cynthia D. Guy, Lixin Zhu, Ruixin Zhu, Patrizia Farci, Wensheng Liu, Sugantha Govindarajan, Fausto Zamboni, Dingfeng Wu, Susan S. Baker, Zhiwei Cao, Anna Mae Diehl, Manal F. Abdelmalek, Cynthia A. Moylan, Robert D. Baker, Weili Lin
Publikováno v:
The Journal of Pathology. 238:531-542
Obese animals and non-alcoholic fatty liver disease (NAFLD) patients exhibit elevated blood alcohol, suggesting potential contributions of alcohol metabolism to the development of NAFLD. Liver gene expression in patients with biopsy-proven mild (N =