Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Dan Xu"'
Publikováno v:
Toxicology Letters. 331:167-177
Prenatal ethanol exposure (PEE) could increase offspring’s susceptibility to adult liver lipid-metabolism diseases. This study aimed to confirm intrauterine programming mechanism of glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis for liv
Publikováno v:
Reproductive Toxicology. 96:36-46
Epidemiological investigations have found that maternal alcohol intake increases the risk of mental illness in offspring. Our study investigated changes of depression- and anxiety-like behaviors in adult offspring caused by prenatal ethanol exposure
Autor:
Ke Li, Shuwei Hu, Zhexiao Jiao, Shiyun Dai, Hui Wang, Xiaohan Gong, Dan Xu, Tao Jiang, Yiwen Yi
Publikováno v:
Archives of Toxicology. 94:3201-3215
Partial temporal lobe epilepsy (TLE) has an intrauterine developmental origin. This study was aimed at elucidating the heritable effects and programming mechanism of TLE in offspring rats induced by prenatal dexamethasone exposure (PDE). Pregnant Wis
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Our previous studies showed that prenatal ethanol exposure (PEE) elevated blood total cholesterol (TCH) level in adult offspring rats. This study was aimed at elucidating the intrauterine programming mechanism of hypercholesterolemia in adult rats in
Publikováno v:
Toxicology. 418:11-21
Clinical and animal studies have indicated that hypercholesterolemia has intrauterine developmental origin. Our previous studies showed that prenatal caffeine exposure (PCE) increased the serum total cholesterol (TCH) levels in adult offspring rats.
Publikováno v:
Food and Chemical Toxicology. 123:314-325
Prenatal nicotine exposure (PNE) can cause hypersensitivity of hypothalamic-pituitary-adrenal (HPA) axis in offspring with intrauterine growth retardation. The purpose of this study was to explore the original mechanism of intrauterine development th
Autor:
Tingting Wang, Mingcui Luo, Shiyun Dai, Dan Xu, Ke Li, Liaobin Chen, Shuwei Hu, Hui Wang, Xufeng Li, Yiwen Yi, Tao Jiang
Publikováno v:
Cell biology and toxicology. 38(1)
Depression is a neuropsychiatric disorder and has intrauterine developmental origins. This study aimed to confirm the depression susceptibility in offspring rats induced by prenatal dexamethasone exposure (PDE) and to further explore the intrauterine
Autor:
Xiaohan Gong, Zhexiao Jiao, Ke Li, Hui Wang, Dan Xu, Shiyun Dai, Yiwen Yi, Songqiang Huang, Shuwei Hu, Zewen Hu, Wanting Dong, Shuai Zhang
Publikováno v:
Cell biology and toxicologyReferences.
Dexamethasone is a commonly used synthetic glucocorticoid in the clinic. As a compound that can cross the placental barrier to promote fetal lung maturation, dexamethasone is extensively used in pregnant women at risk of premature delivery. However,
Publikováno v:
Toxicology letters. 331
This study was intended to demonstrate that prenatal dexamethasone exposure (PDE) can induce low basal activity of the hypothalamic-pituitary-adrenal axis (HPAA) in male offspring rats and explore the underlying mechanism. Pregnant rats were subcutan
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
Epidemiological investigations have suggested that periodic use of dexamethasone during pregnancy is a risk factor for abnormal behavior in offspring, but the potential mechanism remains unclear. In this study, we investigated the changes in the glut