Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Hansell A"'
Autor:
Hans Richter, Mitchell C. Lock, Gina L. J. Galli, Olga V. Patey, Eduardo Villamor, Emilio A. Herrera, Dino A. Giussani, Andrew W. Trafford, Jeremy A. Hansell, Emily J. Camm, Carlos E. Blanco
Publikováno v:
Hansell, J A, Richter, H G, Camm, E J, Herrera, E A, Blanco, C E, Villamor, E, Patey, O V, Lock, M C, Trafford, A W, Galli, G L J & Giussani, D A 2022, ' Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy ', Journal of Pineal Research, vol. 72, no. 1, e12766 . https://doi.org/10.1111/jpi.12766
Journal of Pineal Research, 72(1):e12766. Wiley-Blackwell
Journal of Pineal Research, 72(1):e12766. Wiley-Blackwell
Funder: British Heart Foundation; Id: http://dx.doi.org/10.13039/501100000274
Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal
Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b6e50f8550d087295176e17ef513e5
https://hdl.handle.net/11541.2/29472
https://hdl.handle.net/11541.2/29472
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F278-F283
Diabetes mellitus is associated with decreased nitric oxide bioavailability thereby affecting renal blood flow regulation. Previous reports have demonstrated that cellular uptake of l-arginine is rate limiting for nitric oxide production and that pla
Publikováno v:
Upsala Journal of Medical Sciences
Objectives. Accumulation of extracellular matrix (ECM) components is an early sign of diabetic nephropathy. Also the glycosaminoglycan hyaluronan (HA) is elevated in the renal interstitium during experimental diabetes. The mammalian target of rapamyc
Publikováno v:
Kidney International. 87:109-115
Diabetes is associated with increased risk for development of kidney disease, and an increased glomerular filtration rate is an early indication of altered kidney function. Here we determine whether reduced adenosine A 2a receptor–mediated vasodila
Publikováno v:
Upsala Journal of Medical Sciences
Background. Hyaluronan (HA) is the dominant glycosaminoglycan in the renomedullary interstitium. Renomedullary HA has been implicated in tubular fluid handling due to its water-attracting properties and the changes occurring in parallel to acute vari
Autor:
Malou Friederich-Persson, Fredrik Palm, Masaomi Nangaku, Erik Thörn, Max Levin, Peter Hansell
Publikováno v:
Hypertension. 62:914-919
Diabetic nephropathy is strongly associated with both increased oxidative stress and kidney tissue hypoxia. The increased oxidative stress causes increased kidney oxygen consumption resulting in kidney tissue hypoxia. To date, it has been difficult t
Autor:
Peter Hansell, Angelica Fasching, Liselotte Pihl, Patrik Persson, Gerald F. DiBona, Fredrik Palm
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R39-R47
Glomerular filtration rate (GFR) and renal blood flow (RBF) are normally kept constant via renal autoregulation. However, early diabetes results in increased GFR and the potential mechanisms are debated. Tubuloglomerular feedback (TGF) inactivation,
Autor:
Cecilia Johnsson, Mayumi Ikegami-Kawai, Tomoko Takahashi, Peter Hansell, Louise Rügheimer, Fredrik Palm, Johan Olerud, A B M Åstrand, Peter Friberg, Y Chen, D Kerjaschki, Sara Stridh
Publikováno v:
Matrix Biology. 30:62-69
A functional renin-angiotensin system (RAS) is required for normal kidney development. Neonatal inhibition of the RAS in rats results in long-term pathological renal phenotype and causes hyaluronan (HA), which is involved in morphogenesis and inflamm
Autor:
Takahisa Kawakami, Angelica Fasching, Fredrik Palm, Fuyuhiko Nishijima, Tetsuhiro Tanaka, Lina Nordquist, Masaomi Nangaku, Toshiro Fujita, Peter Hansell
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F380-F386
In addition to causing uremic symptoms, uremic toxins accelerate the progression of renal failure. To elucidate the pathophysiology of uremic states, we investigated the effect of indoxyl sulfate (IS), a representative uremic toxin, on oxygen metabol
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F416-F420
Nitric oxide (NO) is a potent regulator of both vascular tone and cellular oxygen consumption (Qo2). Diabetic kidneys have reduced NO availability and increased Qo2. However, the exact nitric oxide synthase (NOS) isoform regulating Qo2, hemodynamics,