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Autor:
V.P. Pishak, M.O. Ryznychuk
Publikováno v:
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 13:195-202
On the long multistage pathway of biosynthesis of steroid hormones from cholesterol to cortisol, testosterone and estradiol, due to mutations in genes, there is the deficiency of steroidogenesis enzymes in the adrenal glands: cholesterol desmolase,
Publikováno v:
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 13:463-467
Background. The purpose of our research was a comparative analysis of specificity and severity of kidney dysfunction in the early period of alloxan- and streptozotocin-induced diabetes mellitus. Materials and methods. The article presents data concer
Autor:
Ana Carolina Medeiros, R.B. Malvestio, Sabatino Maione, R.L. de Freitas, Sylmara Esther Negrini-Ferrari, Mariana Oliveira-Silva, L. Luongo, Norberto Cysne Coimbra, Patrícia Medeiros, Cláudia Maria Padovan
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that is putatively implicated in the chronic pain and depression. We investigated the activity of PrL cortex neurons in Wistar rats that underwent chronic cons
Publikováno v:
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 15:23-26
Background. 5’AMP-activated protein kinase (AMPK) is an enzyme that controls the cell energy balance. With energetic stress in the cell and an increase in the AMP concentration, ATP is replaced by AMP in the exchange centers, resulting in the all
Autor:
E. Vazi, F. Holanda, C.V. Cardoso, Neife Aparecida Guinaim dos Santos, Eduardo Fernandes Bondan, Maria Marlene Martins
Publikováno v:
Research in Veterinary Science. 138:39-48
Methotrexate (MTX), an antifolate drug, is widely used in chemotherapeutic protocols for metastatic and primary brain tumors and some autoimmune diseases. Its efficacy for brain tumors is limited by the high incidence of central nervous system (CNS)
Publikováno v:
Reproductive Toxicology. 104:16-26
Experimental models of maternal diabetes lead to the intrauterine programming of Gestational Diabetes Mellitus (GDM) in the offspring, together with an intrauterine proinflammatory environment, feto-placental metabolic alterations and fetal overgrowt
Autor:
Zhengzi Yi, Joshua J. Strohl, Ramalingam Bethunaickan, Rakesh Mishra, Patricio T. Huerta, Anne Davidson, Celine C. Berthier, Weijia Zhang
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Molecular Medicine
Molecular Medicine
Background We have found disruption of expression of major transcriptional regulators of circadian rhythm in the kidneys of several mouse models of lupus nephritis. Here we define the consequence of this disturbance with respect to circadian gene exp
Autor:
Dake Qi, Siqian Fu, Cui Li, Baiyang You, Suixin Liu, Fan Zheng, Wenliang Zhang, Jeffrey W. Ripley-Gonzalez, Ling Qiu, Yaoshan Dun
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Obesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction. Trimetazidi
Publikováno v:
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 15:583-590
Актуальність. Діабетична нефропатія стала основною причиною термінальної стадії ниркової недостатності. Фактор пігментного епітелію (
Publikováno v:
Acta Histochemica et Cytochemica
In this study we investigated the neuroprotective efficacy of dexmedetomidine (Dex) and phosphocreatine (PCr) alone or in combination in a rat model of focal cerebral ischemia-reperfusion injury (I/R). I/R was induced by intraluminal middle cerebral